Sost^tm1Lhe
Targeted Allele Detail

Summary

• Symbol: Sost^tm1Lhe
• Name: sclerostin; targeted mutation 1, Lin He
• MGI ID: MGI:4941817
• Gene: Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
• Alliance: Sost^tm1Lhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic region of coding sequence (CDS) extending from exon 1 to exon 2 of the gene was replaced with a LacZ gene and a PGK-Neomycin cassette by targeted homologous recombination. RT-PCR confirmed absence of transcript, and Western blot confirmed absence of protein product in femur. This is a null allele. (J:168665)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sost Mutation: 34 strains or lines available

References

• Original: J:168665 Lin C, et al., Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res. 2009 Oct;24(10):1651-61
• All: 1 reference(s)