Atg7
Gene Detail

Symbol Name ID

Atg7 autophagy related 7 MGI:1921494

Synonyms

1810013K23Rik, Apg7l

Feature Type

protein coding gene

Genetic Map

Chromosome 6

53.05 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:114643097-114860595 bp, + strand From Ensembl annotation of GRCm38   217499 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Atg7

Human homologs

Human Homolog		ATG7, autophagy related 7
NCBI Gene ID		10533
neXtProt AC		NX_O95352
Human Synonyms		APG7L, APG7-LIKE, GSA7
Human Chr (Location)		3p25.3; chr3:11314010-11599139 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(28) : Targeted(2) Gene trapped(26)
 

Mutation of this gene causes impairment of constitutive and starvation-induced autophagy resulting in defective protein degradation. Homozygous null mice die within 1 day of birth and have decreased body weight.

 
Human Diseases Modeled Using Mouse Atg7 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	adult walking behavior, autophagy, ...
Component	cytoplasm
Function	APG12 activating enzyme activity, catalytic activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (41)    Tissues (28)    Images (12)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(20)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000030314 (Evidence)
Entrez Gene	74244 (Evidence)
Consensus CDS Project	CCDS39598.1
International Mouse Knockout Project Status	Atg7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030314	Ensembl Gene Model | MGI Sequence Detail	217499	C57BL/6J
transcript	ENSMUST00000169310	Ensembl | MGI Sequence Detail	3863	Not Applicable
polypeptide	ENSMUSP00000133215	Ensembl | MGI Sequence Detail	698	Not Applicable

All sequences(44) RefSeq(6) UniProt(3)

Polymorphisms

SNPs(683 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009036	Molybdenum cofactor biosynthesis, MoeB
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR000594	UBA/THIF-type NAD/FAD binding fold
InterPro	IPR006285	Ubiquitin-like modifier-activating enzyme Atg7
Protein Ontology	PR:000004419	autophagy-related protein 7

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192564 Zhou J, et al., AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents. FEBS Lett. 2013 Jan 16;587(2):170-7
All references(90)