About   Help   FAQ
Atg7 Gene Detail
Summary
  • Symbol
    Atg7
  • Name
    autophagy related 7
  • Synonyms
    1810013K23Rik, Apg7l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921494
    NCBI Gene: 74244
  • Gene Overview
    MyGene.info: ATG7
Location & Maps
more
  • Sequence Map
    Chr6:114643097-114860614 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      217518 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.05 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATG7, autophagy related 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATG7, autophagy related 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APG7L, APG7-LIKE, GSA7
  • Links
    NCBI Gene ID: 10533
    neXtProt AC: NX_O95352

  • Chr Location
    3p25.3; chr3:11272324-11557665 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4662
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ATG7
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Atg7 mouse models

Human Disease Mouse Models
       Myelodysplastic Syndrome; MDS   OMIM: 614286 View 1 model
Parkinson Disease, Late-Onset; PD   OMIM: 168600 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 2 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Gene trapped
    26
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Atg7
  • Incidental Mutations
Mutation of this gene causes impairment of constitutive and starvation-induced autophagy resulting in defective protein degradation. Homozygous null mice die within 1 day of birth and have decreased body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043567 VEGA Gene Model | MGI Sequence Detail 217518 C57BL/6J ±  kb
transcript OTTMUST00000114373 VEGA | MGI Sequence Detail 3895 Not Applicable  
polypeptide OTTMUSP00000063828 VEGA | MGI Sequence Detail 741 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1336 from dbSNP Build 142
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000004419 ubiquitin-like modifier-activating enzyme ATG7
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR000594 THIF-type NAD/FAD binding fold
    IPR006285 Ubiquitin-like modifier-activating enzyme Atg7
    IPR032197 Ubiquitin-like modifier-activating enzyme Atg7, N-terminal
Molecular
Reagents
less
  • All nucleic 79
    cDNA 78
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 179
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 27
    Phenotypes 129
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229532 Santanam U, et al., Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 2016 Feb 15;30(4):399-407

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory