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Atg7
Gene Detail
Symbol

Name
ID
Atg7
autophagy related 7
MGI:1921494
Synonyms
1810013K23Rik, Apg7l
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.05 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:114643097-114860614 bp, + strand
From VEGA annotation of GRCm38

  217518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATG7
Gene Tree: Atg7

Human
homologs
ATG7, autophagy related 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10533
neXtProt AC: NX_O95352

Human Synonyms: APG7L, APG7-LIKE, GSA7

Human Chr (Location): 3p25.3; chr3:11272324-11557665 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Spontaneous(1) Targeted(2)
Genomic Mutations involving Atg7 (1)
Incidental mutations (data from CvDC )
 
Mutation of this gene causes impairment of constitutive and starvation-induced autophagy resulting in defective protein degradation. Homozygous null mice die within 1 day of birth and have decreased body weight.
 
Human Diseases Modeled in Mice Using Atg7 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Atg7 interacts with 222 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process adult walking behavior, autophagosome assembly, ...
Component axoneme, cytoplasm, ...
Function Atg12 activating enzyme activity, Atg8 activating enzyme activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (50)    Tissues (30)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
RT-PCR 9
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atg7 ; ZFIN atg7    NEW 
Molecular
reagents
All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000043567 (Evidence)
Ensembl Gene Model ENSMUSG00000030314 (Evidence)
Entrez Gene 74244 (Evidence)
UniGene 275332
DFCI TC1574450, TC1628424, TC1592551, TC1680720
Consensus CDS Project CCDS39598.1, CCDS59697.1
International Mouse Phenotyping Consortium Status Atg7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043567 VEGA Gene Model | MGI Sequence Detail 217518 C57BL/6J ±  kb
transcript OTTMUST00000114373 VEGA | MGI Sequence Detail 3895 Not Applicable 
polypeptide OTTMUSP00000063828 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(20) UniProt(12)
Polymorphisms
SNPs within 2kb(1344 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR006285 Ubiquitin-like modifier-activating enzyme Atg7
Protein Ontology PR:000004419 ubiquitin-like modifier-activating enzyme ATG7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220772 Li-Harms X, et al., Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. Blood. 2015 Jan 1;125(1):162-74
All references(158)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory