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Atg7
Gene Detail
Symbol

Name
ID
Atg7
autophagy related 7
MGI:1921494
Synonyms
1810013K23Rik, Apg7l
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.05 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:114643097-114860614 bp, + strand
From VEGA annotation of GRCm38

  217518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Atg7

Human
homologs
Human Homolog ATG7, autophagy related 7
NCBI Gene ID 10533
neXtProt AC  NX_O95352
Human Synonyms  APG7L, APG7-LIKE, GSA7
Human Chr (Location)  3p25.3; chr3:11272324-11557665 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(26) Targeted(2)
 
Mutation of this gene causes impairment of constitutive and starvation-induced autophagy resulting in defective protein degradation. Homozygous null mice die within 1 day of birth and have decreased body weight.
 
Human Diseases Modeled Using Mouse Atg7 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Atg7 interacts with 223 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process adult walking behavior, autophagy, ...
Component axoneme, cytoplasm, ...
Function Atg12 activating enzyme activity, Atg8 activating enzyme activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (41)    Tissues (28)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000043567 (Evidence)
Ensembl Gene ModelENSMUSG00000030314 (Evidence)
Entrez Gene74244 (Evidence)
UniGene275332
DFCITC1574450, TC1680720, TC1592551, TC1628424
Consensus CDS ProjectCCDS39598.1, CCDS59697.1
International Mouse Knockout Project StatusAtg7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043567 VEGA Gene Model | MGI Sequence Detail 217518 C57BL/6J ±  kb
transcript OTTMUST00000114373 VEGA | MGI Sequence Detail 3895 Not Applicable 
polypeptide OTTMUSP00000063828 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(14) UniProt(21)
Polymorphisms
SNPs within 2kb(1344 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR006285 Ubiquitin-like modifier-activating enzyme Atg7
Protein Ontology PR:000004419 ubiquitin-like modifier-activating enzyme ATG7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213960 Kim J, et al., Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells induces diabetes. J Clin Invest. 2014 Aug 1;124(8):3311-24
All references(140)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory