Symbol
Name
ID

Atg7
autophagy related 7
MGI:1921494

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

cellular phenotype

oligozoospermia

abnormal acrosome morphology

abnormal acrosome assembly

abnormal proacrosomal vesicle fusion

globozoospermia

abnormal sperm nucleus morphology

abnormal intestinal goblet cell morphology

abnormal intracellular organelle morphology

abnormal endoplasmic reticulum morphology

abnormal hepatocyte mitochondrial morphology

dilated mitochondrion

abnormal autophagy

abnormal autophagosome formation

impaired autophagy

increased male germ cell apoptosis

increased neuron apoptosis

abnormal melanocyte proliferation

increased hepatocyte proliferation

early cellular replicative senescence

oxidative stress

Availability

Mouse Genotype

Atg7^tm1.1Tchi/Atg7^tm1.1Tchi

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(Mx1-cre)1Cgn/0 (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(Nes-cre)1Wme/0 (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Avil^tm2(cre)Fawa/Avil⁺ (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(Vil1-cre)1000Gum/0 (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(Camk2a-cre)T29-1Stl/0 (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(Tyr-cre)1Lru/Y (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(Nes-cre)1Kln/0 (conditional)

Alpl^tm1(cre)Nagy/Alpl⁺
Atg7^tm1Tchi/Atg7^tm1Tchi (conditional)

Atg7^tm1Tchi/Atg7^tm1Tchi
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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