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Als2
Gene Detail
 Symbol
Name
ID
Als2
amyotrophic lateral sclerosis 2 (juvenile)
MGI:1921268
Synonyms 3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563
Feature Type protein coding gene
Genetic Map
Chromosome 1
29.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:59162926-59237231 bp, - strand
From VEGA annotation of GRCm38

  74306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Als2

Human
homologs
Human Homolog ALS2, amyotrophic lateral sclerosis 2 (juvenile)
NCBI Gene ID 57679
neXtProt AC  NX_Q96Q42
Human Synonyms  ALS2CR6, ALSJ, IAHSP, PLSJ
Human Chr (Location)  2q33.1; chr2:201700263-201781172 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human ALS2
Alleles
and
phenotypes
All alleles(26) : Targeted(7) Gene trapped(19)
 
Homozygous null mutations in this gene may result in increased body weight, altered endosome trafficking, modest motor behavioral abnormalities, altered anxiety responses, impaired axonal transport, and mild neurolopathogical deficits including axonal degeneration in the corticospinal tract.
 
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process axonogenesis, behavioral fear response, ...
Component axon, cell, ...
Function guanyl-nucleotide exchange factor activity, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (84)    Tissues (32)    Images (32)
Theiler Stages: 17, 19, 23, 28
Assay TypeResults
RNA in situ 84
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(14) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021752 (Evidence)
Ensembl Gene ModelENSMUSG00000026024 (Evidence)
Entrez Gene74018 (Evidence)
Consensus CDS ProjectCCDS35583.1
International Mouse Knockout Project StatusAls2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021752 VEGA Gene Model | MGI Sequence Detail 74306 C57BL/6J ±  kb
transcript OTTMUST00000051627 VEGA | MGI Sequence Detail 6342 Not Applicable 
polypeptide OTTMUSP00000024337 VEGA | MGI Sequence Detail 1651 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(627 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR003409 MORN motif
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR003123 Vacuolar sorting protein 9
Protein Ontology PR:000003971 alsin
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190122 Cobanoglu G, et al., Are alsin and spartin novel interaction partners?. Biochem Biophys Res Commun. 2012 Oct 12;427(1):1-4
All references(52)
Other
accession IDs
MGI:1924543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory