Automated description from the Alliance of Genome Resources (Release 6.0.0)
Predicted to enable several functions, including GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within several processes, including behavioral fear response; glutamatergic synaptic transmission; and neuromuscular junction development. Located in several cellular components, including centrosome; postsynaptic density; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2).