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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Als2
alsin Rho guanine nucleotide exchange factor
MGI:1921268
31 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Als2tm1Cai/Als2tm1Cai
involves: 129X1/SvJ * C57BL/6J
abnormal motor learning J:100336
decreased exploration in new environment J:100336
impaired coordination J:100336
increased anxiety-related response J:100336
increased body weight J:100336
increased physiological sensitivity to xenobiotic J:100336
increased susceptibility to xenobiotic induced morbidity/mortality J:100336
normal nervous system phenotype J:100336
Als2tm1Deng/Als2tm1Deng
involves: 129
abnormal corticospinal tract morphology J:129939
impaired coordination J:129939
neurodegeneration J:129939
Als2tm1Garo/Als2tm1Garo
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
abnormal axon morphology J:138147
abnormal axonal transport J:138147
abnormal corticospinal tract morphology J:138147
abnormal physical strength J:138147
abnormal ventral spinal root morphology J:138147
axon degeneration J:138147
impaired coordination J:138147
Als2tm1Hay/Als2tm1Hay
involves: 129S1/SvImJ * C57BL/6J
abnormal motor neuron morphology J:111035
abnormal neuron morphology J:111035
decreased locomotor activity J:111035
Als2tm1Jei/Als2tm1Jei
involves: 129P2/OlaHsd * C57BL/6J
abnormal action potential J:104446
abnormal motor neuron innervation pattern J:104446
abnormal neuromuscular synapse morphology J:104446
abnormal Purkinje cell morphology J:104446
abnormal skeletal muscle fiber morphology J:104446
abnormal skeletal muscle fiber type ratio J:104446
astrocytosis J:104446
normal behavior/neurological phenotype J:104446
centrally nucleated skeletal muscle fibers J:104446
CNS inflammation J:104446
decreased motor neuron number J:104446
decreased Purkinje cell number J:104446
skeletal muscle fiber atrophy J:104446

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory