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Ttc21b
Gene Detail
Symbol

Name
ID
Ttc21b
tetratricopeptide repeat domain 21B
MGI:1920918
Synonyms
2410066K11Rik, aln, line 158, Thm1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
39.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:66184327-66256617 bp, - strand
From VEGA annotation of GRCm38

  72291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TTC21B
Gene Tree: Ttc21b

Human
homologs
TTC21B, tetratricopeptide repeat domain 21B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 79809
neXtProt AC: NX_Q7Z4L5

Human Synonyms: ATD4, IFT139, JBTS11, Nbla10696, NPHP12, SRTD4, THM1

Human Chr (Location): 2q24.3; chr2:165873362-165953838 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TTC21B

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene is embryonic lethal. Mutant embryos exhibit several deformities including polydactyly, microphthalmia, irregular shape of the long bones, rib fusion and truncation, neural tube defects, and abnormal brain structure.
 
Interactions
Ttc21b interacts with 164 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cilium morphogenesis, forebrain dorsal/ventral pattern formation, ...
Component cell, cell projection, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (8)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ttc21b ; ZFIN ttc21b    NEW 
Molecular
reagents
All nucleic(40) cDNA(36) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012999 (Evidence)
Ensembl Gene Model ENSMUSG00000034848 (Evidence)
Entrez Gene 73668 (Evidence)
UniGene 250868
DFCI TC1618824, TC1601624, TC1665495
DoTS DT.40140209, DT.103561517, DT.489600, DT.94253245
NIA Mouse Gene Index U022694
Consensus CDS Project CCDS16076.1, CCDS71061.1
International Mouse Phenotyping Consortium Status Ttc21b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012999 VEGA Gene Model | MGI Sequence Detail 72291 C57BL/6J ±  kb
transcript OTTMUST00000031324 VEGA | MGI Sequence Detail 4470 Not Applicable 
polypeptide OTTMUSP00000014010 VEGA | MGI Sequence Detail 1315 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(722 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000016779 tetratricopeptide repeat protein 21B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213263 Tran PV, et al., Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models. J Am Soc Nephrol. 2014 Apr 3;
All references(36)
Other
accession IDs
MGI:2152543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory