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Ttc21b
Gene Detail
 Symbol
Name
ID
Ttc21b
tetratricopeptide repeat domain 21B
MGI:1920918
Synonyms 2410066K11Rik, aln, line 158, Thm1
Feature Type protein coding gene
Genetic Map
Chromosome 2
39.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:66184327-66256617 bp, - strand
From VEGA annotation of GRCm38

  72291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ttc21b

Human
homologs
Human Homolog TTC21B, tetratricopeptide repeat domain 21B
NCBI Gene ID 79809
neXtProt AC  NX_Q7Z4L5
Human Synonyms  ATD4, IFT139, JBTS11, NPHP12, SRTD4, THM1
Human Chr (Location)  2q24.3; chr2:165873362-165953838 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human TTC21B
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene is embryonic lethal. Mutant embryos exhibit several deformities including polydactyly, microphthalmia, irregular shape of the long bones, rib fusion and truncation, neural tube defects, and abnormal brain structure.
 
Interactions
Ttc21b interacts with 164 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cilium morphogenesis, forebrain dorsal/ventral pattern formation, ...
Component cell, cell projection, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012999 (Evidence)
Ensembl Gene ModelENSMUSG00000034848 (Evidence)
Entrez Gene73668 (Evidence)
UniGene250868
DFCITC1601624, TC1618824, TC1665495
DoTSDT.103561517, DT.40140209, DT.489600, DT.94253245
NIA Mouse Gene IndexU022694
Consensus CDS ProjectCCDS16076.1, CCDS71061.1
International Mouse Knockout Project StatusTtc21b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012999 VEGA Gene Model | MGI Sequence Detail 72291 C57BL/6J ±  kb
transcript OTTMUST00000031324 VEGA | MGI Sequence Detail 4470 Not Applicable 
polypeptide OTTMUSP00000014010 VEGA | MGI Sequence Detail 1315 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(722 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000016779 tetratricopeptide repeat protein 21B
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178620 Hong W, et al., Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. Biochem Biophys Res Commun. 2011 Dec 2;415(4):650-5
All references(34)
Other
accession IDs
MGI:2152543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory