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Ttc21baln
Chemically induced Allele Detail
Summary
Symbol: Ttc21baln
Name: tetratricopeptide repeat domain 21B; alien
MGI ID: MGI:2152544
Synonyms: alien, Alien, line 158
Gene: Ttc21b  Location: Chr2:66014671-66086961 bp, - strand  Genetic Position: Chr2, 39.08 cM
Alliance: Ttc21baln page
Mutation
origin
Strain of Origin:  A/J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA developmental mutation identified in an ENU mutagenesis screen. An A to C mutation near the N-terminus converts the highly conserved glutamine at amino acid residue 15 to a proline. Western blot analysis indicates an absence of protein product in homozygotes. (J:133725)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttc21b Mutation:  52 strains or lines available
Notes
The Rab23 gene has been excluded as a candidate gene for this mutation.
References
Original:  J:75360 Herron BJ, et al., Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet. 2002 Feb;30(2):185-9
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory