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Smc4 Gene Detail
Summary
  • Symbol
    Smc4
  • Name
    structural maintenance of chromosomes 4
  • Synonyms
    2500002A22Rik, Smc4l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917349
    NCBI Gene: 70099
  • Gene Overview
    MyGene.info: SMC4
Location & Maps
more
  • Sequence Map
    Chr3:69004738-69034623 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29886 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 32.14 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPC, CAP-C, SMC-4, SMC4L1
  • Links
    NCBI Gene ID: 10051
    neXtProt AC: NX_Q9NTJ3

  • Chr Location
    3q25.33; chr3:160399304-160434962 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4015
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMC4
  • Protein SuperFamily
    SMC
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Smc4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024475 VEGA Gene Model | MGI Sequence Detail 29886 C57BL/6J ±  kb
transcript OTTMUST00000060029 VEGA | MGI Sequence Detail 4316 Not Applicable  
polypeptide OTTMUSP00000029262 VEGA | MGI Sequence Detail 1286 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    152 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 305
    cDNA 305

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140067
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:195518 Pan X, et al., YY1 controls Igkappa repertoire and B-cell development, and localizes with condensin on the Igkappa locus. EMBO J. 2013 Apr 17;32(8):1168-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory