About   Help   FAQ
Smc4 Gene Detail
Summary
  • Symbol
    Smc4
  • Name
    structural maintenance of chromosomes 4
  • Synonyms
    2500002A22Rik, Smc4l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917349
    NCBI Gene: 70099
  • Gene Overview
    MyGene.info: SMC4
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:69004972-69034623 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 32.14 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917349
protein coding gene Chr3:69004738-69034623 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027291
protein coding gene Chr3:68225775-68259364 (+)
A/J MGP_AJ_G0027253
protein coding gene Chr3:66190437-66220373 (+)
AKR/J MGP_AKRJ_G0027221
protein coding gene Chr3:67608106-67638072 (+)
BALB/cJ MGP_BALBcJ_G0027264
protein coding gene Chr3:66067613-66098512 (+)
C3H/HeJ MGP_C3HHeJ_G0027008
protein coding gene Chr3:67848756-67879808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027710
protein coding gene Chr3:70776446-70808422 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025063
protein coding gene Chr3:62456273-62486401 (+)
CAST/EiJ MGP_CASTEiJ_G0026455
protein coding gene Chr3:67800945-67832088 (+)
CBA/J MGP_CBAJ_G0026983
protein coding gene Chr3:72961096-72992722 (+)
DBA/2J MGP_DBA2J_G0027119
protein coding gene Chr3:65697787-65728300 (+)
FVB/NJ MGP_FVBNJ_G0027087
protein coding gene Chr3:64319563-64349857 (+)
LP/J MGP_LPJ_G0027227
protein coding gene Chr3:69162634-69192840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027106
protein coding gene Chr3:77576692-77605259 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027768
protein coding gene Chr3:67498534-67529886 (+)
PWK/PhJ MGP_PWKPhJ_G0026189
protein coding gene Chr3:65423690-65454356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026005
protein coding gene Chr3:66603217-66633045 (+)
WSB/EiJ MGP_WSBEiJ_G0026533
protein coding gene Chr3:67654505-67684543 (+)



Homology
more
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPC, CAP-C, SMC-4, SMC4L1
  • Links
    NCBI Gene ID: 10051
    neXtProt AC: NX_Q9NTJ3
    UniProt: Q9NTJ3

  • Chr Location
    3q25.33; chr3:160399304-160434962 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4015
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMC4
  • Protein SuperFamily
    SMC
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70099 NCBI Gene Model | MGI Sequence Detail 29652 C57BL/6J ±  kb
transcript NM_001356976 RefSeq | MGI Sequence Detail 4346 C57BL/6  
polypeptide Q8CG47 UniProt | EBI | MGI Sequence Detail 1286 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 306
    cDNA 306

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140067
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory