Ikbkap
Gene Detail

Symbol Name ID

Ikbkap inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein MGI:1914544

Synonyms

3110040G09Rik, C78473, Elp1, IKAP

Feature Type

protein coding gene

Genetic Map

Chromosome 4

31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:56749680-56802331 bp, - strand From VEGA annotation of GRCm38   52652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: IkappaB kinase complex, IKAP component
Gene Tree: Ikbkap

Human homologs

Human Homolog		IKBKAP, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
NCBI Gene ID		8518
neXtProt AC		NX_O95163
Human Synonyms		DYS, ELP1, FD, IKAP, IKI3, TOT1
Human Chr (Location)		9q31; chr9:111629800-111696608 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IKBKAP

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Mice homozygous for a null allele exhibit embryonic lethality with arrested neural and vascular development.

 
Human Diseases Modeled Using Mouse Ikbkap (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	I-kappaB phosphorylation, positive regulation of cell migration, ...
Component	cytoplasm, DNA-directed RNA polymerase II, holoenzyme, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(191)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(194) cDNA(193) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000007272 (Evidence)
Ensembl Gene Model	ENSMUSG00000028431 (Evidence)
Entrez Gene	230233 (Evidence)
UniGene	282743
DFCI	TC1574036, TC1594958, TC1597840
DoTS	DT.101738534, DT.487618, DT.97362502
NIA Mouse Gene Index	U025084
Consensus CDS Project	CCDS38765.1
International Mouse Knockout Project Status	Ikbkap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007272	VEGA Gene Model | MGI Sequence Detail	52652	C57BL/6J
transcript	OTTMUST00000016798	VEGA | MGI Sequence Detail	6160	Not Applicable
polypeptide	OTTMUSP00000007743	VEGA | MGI Sequence Detail	1333	Not Applicable

All sequences(47) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(259 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006849	IKI3
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000008977	elongator complex protein 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:188923 Dietrich P, et al., IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia. Hum Mol Genet. 2012 Dec 1;21(23):5078-90
All references(44)

Other accession IDs

MGI:2140667