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Ikbkap
Gene Detail
Symbol

Name
ID
Ikbkap
inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein
MGI:1914544
Synonyms
3110040G09Rik, C78473, Elp1, IKAP
Feature Type
protein coding gene
Genetic Map
Chromosome 4
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:56749680-56802331 bp, - strand
From VEGA annotation of GRCm38

  52652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IKBKAP
Protein SuperFamily: IkappaB kinase complex, IKAP component
Gene Tree: Ikbkap

Human
homologs
IKBKAP, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8518
neXtProt AC: NX_O95163

Human Synonyms: DYS, ELP1, FD, IKAP, IKI3, TOT1

Human Chr (Location): 9q31; chr9:108867520-108934328 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IKBKAP

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality with arrested neural and vascular development.
 
Human Diseases Modeled in Mice Using Ikbkap (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(2)
Interactions
Ikbkap interacts with 307 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process I-kappaB phosphorylation, positive regulation of cell migration, ...
Component cytoplasm, Elongator holoenzyme complex, ...
Function ATP binding, phosphorylase kinase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (60)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 35
Northern blot 12
Western blot 2
cDNA source data(191)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ikbkap    NEW 
Molecular
reagents
All nucleic(195) cDNA(194) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000007272 (Evidence)
Ensembl Gene Model ENSMUSG00000028431 (Evidence)
Entrez Gene 230233 (Evidence)
UniGene 282743
DFCI TC1594958, TC1574036, TC1597840
DoTS DT.101738534, DT.487618, DT.97362502
NIA Mouse Gene Index U025084
Consensus CDS Project CCDS38765.1
International Mouse Phenotyping Consortium Status Ikbkap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007272 VEGA Gene Model | MGI Sequence Detail 52652 C57BL/6J ±  kb
transcript OTTMUST00000016798 VEGA | MGI Sequence Detail 6160 Not Applicable 
polypeptide OTTMUSP00000007743 VEGA | MGI Sequence Detail 1333 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(368 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006849 IKI3
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000008977 elongator complex protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:215165 Cheishvili D, et al., IKAP deficiency in an FD mouse model and in oligodendrocyte precursor cells results in downregulation of genes involved in oligodendrocyte differentiation and myelin formation. PLoS One. 2014;9(4):e94612
All references(47)
Disease annotation references (3)
Other
accession IDs
MGI:2140667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory