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Cisd2
Gene Detail
 Symbol
Name
ID
Cisd2
CDGSH iron sulfur domain 2
MGI:1914256
Synonyms 1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, Miner1, Zcd2
Feature Type protein coding gene
Genetic Map
Chromosome 3
62.55 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:135406412-135423925 bp, - strand
From VEGA annotation of GRCm38

  17514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cisd2

Human
homologs
Human Homolog CISD2, CDGSH iron sulfur domain 2
NCBI Gene ID 493856
neXtProt AC  NX_Q8N5K1
Human Synonyms  ERIS, Miner1, NAF-1, WFS2, ZCD2
Human Chr (Location)  4q24; chr4:102828134-102892807 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CISD2
Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(54) Targeted(3)
 
Mice homozygous for a null allele exhibit numerous symptoms of premature aging associated with reduced mitochondrial degeneration.
 
Human Diseases Modeled Using Mouse Cisd2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cisd2 interacts with 271 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process autophagy, mitochondrion degradation, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(93) cDNA(93)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029490 (Evidence)
Ensembl Gene ModelENSMUSG00000028165 (Evidence)
Entrez Gene67006 (Evidence)
UniGene269993
DFCITC1576892, TC1594929, TC1597595, TC1619875, TC1751726
DoTSDT.40163737, DT.533904, DT.55131631, DT.91412720, DT.94368962
NIA Mouse Gene IndexU024679
Consensus CDS ProjectCCDS17856.1
International Mouse Knockout Project StatusCisd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029490 VEGA Gene Model | MGI Sequence Detail 17514 C57BL/6J ±  kb
transcript OTTMUST00000073072 VEGA | MGI Sequence Detail 3361 Not Applicable 
polypeptide OTTMUSP00000037790 VEGA | MGI Sequence Detail 135 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018967 Iron sulphur-containing domain, CDGSH-type
InterPro IPR006622 Iron sulphur-containing domain, CDGSH-type, subfamily
InterPro IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
Protein Ontology PR:000005502 CDGSH iron-sulfur domain-containing protein 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187306 Wu CY, et al., A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. Hum Mol Genet. 2012 Sep 15;21(18):3956-68
All references(39)
Disease annotation references (1)
Other
accession IDs
MGI:1916247, MGI:1916261, MGI:2139813, MGI:2442890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory