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Cisd2 Gene Detail
Summary
  • Symbol
    Cisd2
  • Name
    CDGSH iron sulfur domain 2
  • Synonyms
    1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, Miner1, Zcd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914256
    NCBI Gene: 67006
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:135406412-135423925 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17514 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 62.55 cM, cytoband H2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CISD2, CDGSH iron sulfur domain 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CISD2, CDGSH iron sulfur domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERIS, Miner1, NAF-1, WFS2, ZCD2
  • Links
    NCBI Gene ID: 493856
    neXtProt AC: NX_Q8N5K1
    UniProt: Q8N5K1

  • Chr Location
    4q24; chr4:102868978-102892807 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 36436
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CISD2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cisd2 mouse models; 1 with human CISD2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit numerous symptoms of premature aging associated with reduced mitochondrial degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029490 VEGA Gene Model | MGI Sequence Detail 17514 C57BL/6J ±  kb
    transcript OTTMUST00000073072 VEGA | MGI Sequence Detail 3361 Not Applicable  
    polypeptide OTTMUSP00000037790 VEGA | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      107 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005502 CDGSH iron-sulfur domain-containing protein 2
    • InterPro Domains
      IPR018967 Iron sulphur-containing domain, CDGSH-type
      IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 93

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916247, MGI:1916261, MGI:2139813, MGI:2442890
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:216800 Lu S, et al., A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5292-301

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory