Cisd2
Gene Detail

Symbol Name ID

Cisd2 CDGSH iron sulfur domain 2 MGI:1914256

Synonyms

1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, Miner1, Zcd2

Feature Type

protein coding gene

Genetic Map

Chromosome 3

62.55 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:135406412-135423925 bp, - strand From VEGA annotation of GRCm38   17514 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cisd2

Human homologs

Human Homolog		CISD2, CDGSH iron sulfur domain 2
NCBI Gene ID		493856
neXtProt AC		NX_Q8N5K1
Human Synonyms		ERIS, Miner1, NAF-1, WFS2, ZCD2
Human Chr (Location)		4q24; chr4:103790135-103813964 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CISD2

Alleles and phenotypes

All alleles(57) : Targeted(3) Gene trapped(54)
 

Mice homozygous for a null allele exhibit numerous symptoms of premature aging associated with reduced mitochondrial degeneration.

 
Human Diseases Modeled Using Mouse Cisd2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	autophagy, mitochondrion degradation, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(100) cDNA(100)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000029490 (Evidence)
Ensembl Gene Model	ENSMUSG00000028165 (Evidence)
Entrez Gene	67006 (Evidence)
UniGene	269993
DFCI	TC1576892, TC1594929, TC1597595, TC1619875, TC1751726
DoTS	DT.40163737, DT.533904, DT.55131631, DT.91412720, DT.94368962
NIA Mouse Gene Index	U024679
Consensus CDS Project	CCDS17856.1
International Mouse Knockout Project Status	Cisd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029490	VEGA Gene Model | MGI Sequence Detail	17514	C57BL/6J
transcript	OTTMUST00000073072	VEGA | MGI Sequence Detail	3361	Not Applicable
polypeptide	OTTMUSP00000037790	VEGA | MGI Sequence Detail	135	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018967	Iron sulphur-containing domain, CDGSH-type
InterPro	IPR006622	Iron sulphur-containing domain, CDGSH-type, subfamily
InterPro	IPR019610	Iron sulphur domain-containing, mitoNEET, N-terminal
Protein Ontology	PR:000005502	CDGSH iron-sulfur domain-containing protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187306 Wu CY, et al., A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. Hum Mol Genet. 2012 Sep 15;21(18):3956-68
All references(39)

Other accession IDs

MGI:1916247, MGI:1916261, MGI:2139813, MGI:2442890