Isoc1 Gene Detail

Summary

• Symbol
  Isoc1
• Name
  isochorismatase domain containing 1
• Synonyms
  2610034N03Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1913557
  NCBI Gene: 66307
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr18:58792554-58812642 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, 33.71 cM, cytoband D2
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  785 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913557	protein coding gene	Chr18:58792538-58813440 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024454	protein coding gene	Chr18:58198994-58219838 (+)
A/J	MGP_AJ_G0024420	protein coding gene	Chr18:55856384-55875901 (+)
AKR/J	MGP_AKRJ_G0024390	protein coding gene	Chr18:57390423-57413125 (+)
BALB/cJ	MGP_BALBcJ_G0024420	protein coding gene	Chr18:56007690-56027968 (+)
C3H/HeJ	MGP_C3HHeJ_G0024187	protein coding gene	Chr18:57600921-57622879 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024866	protein coding gene	Chr18:60009882-60031222 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022298	protein coding gene	Chr18:55422826-55442684 (+)
CAST/EiJ	MGP_CASTEiJ_G0023661	protein coding gene	Chr18:57632995-57715643 (+)
CBA/J	MGP_CBAJ_G0024157	protein coding gene	Chr18:61940065-61970182 (+)
DBA/2J	MGP_DBA2J_G0024287	protein coding gene	Chr18:55546223-55570159 (+)
FVB/NJ	MGP_FVBNJ_G0024254	protein coding gene	Chr18:54927349-54948097 (+)
LP/J	MGP_LPJ_G0024372	protein coding gene	Chr18:58118693-58140213 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024284	protein coding gene	Chr18:63464223-63485222 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024913	protein coding gene	Chr18:57523293-57542607 (+)
PWK/PhJ	MGP_PWKPhJ_G0023405	protein coding gene	Chr18:55576865-55657822 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023211	protein coding gene	Chr18:57605154-57689979 (+)
WSB/EiJ	MGP_WSBEiJ_G0023724	protein coding gene	Chr18:57419435-57441233 (+)

Homology

• Human Ortholog
  ISOC1, isochorismatase domain containing 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ISOC1, isochorismatase domain containing 1
  
• Synonyms
  CGI-111
• Links
  HGNC:24254

  NCBI Gene ID: 51015

  UniProt: Q96CN7

  
  
• Chr Location
  5q23.3; chr5:129094749-129114028 (+)  GRCh38

---

• MGI Vertebrate Homology
  Isoc1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ISOC1
• Gene Tree
  Isoc1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotype references
  

• All Mutations and Alleles
  8
• Endonuclease-mediated
  2
• Gene trapped
  2
• Radiation induced
  2
• Targeted
  2
• Genomic Mutations
  2 involving Isoc1
• Incidental Mutations
  Mutagenetix
• Find Mice (IMSR)
  13 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  3

Expression

• Assay Results
  713
• Tissues
  5
• cDNA Data
  9
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase isoc1
  ZFIN isoc1

Sequences &
Gene Models

• All Sequences
  43
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS29265.1

• Ensembl
  ENSMUSG00000024601 (Evidence)
• NCBI Gene
  66307

Representative Sequences			Length	Strain/Species
genomic	66307	NCBI Gene Model | MGI Sequence Detail	20089	C57BL/6J
transcript	NM_025478	RefSeq | MGI Sequence Detail	2563	C57BL/6
polypeptide	Q91V64	UniProt | EBI | MGI Sequence Detail	297	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000031796 isochorismatase domain-containing protein 1
  (term hierarchy)
• InterPro Domains
  IPR050993 Isochorismatase domain-containing protein
  IPR000868 Isochorismatase-like
  IPR036380 Isochorismatase-like superfamily
• GlyGen
  Q91V64 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 9

  cDNA 9

  
  

  Microarray probesets 6

References

• Summaries
  All 40

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 3

  Phenotypes 16
• Earliest
  J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80(1):220-246
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Isoc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151220	Chr18:58792515-58792594 (+)	1 bp
Tssr151221	Chr18:58800831-58800836 (+)	8,280 bp
Tssr151222	Chr18:58810993-58811011 (+)	18,448 bp
Tssr151223	Chr18:58811089-58811112 (+)	18,547 bp