Porcn
Gene Detail

Symbol Name ID

Porcn porcupine homolog (Drosophila) MGI:1890212

Synonyms

2410004O13Rik, DXHXS7465e, mMg61, Mporc, porc

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

ChrX:8193848-8206525 bp, - strand From VEGA annotation of GRCm38   12678 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Porcn

Human homologs

Human Homolog		PORCN, porcupine homolog (Drosophila)
NCBI Gene ID		64840
neXtProt AC		NX_Q9H237
Human Synonyms		DHOF, FODH, MG61, por, PORC, PPN
Human Chr (Location)		Xp11.23; chrX:48367371-48379202 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PORCN

Alleles and phenotypes

All alleles(24) : Targeted(6) Gene trapped(18)
 

Mice homozygous for a conditional allele activated in the epiblast exhibit abnormal mesoderm development, dermal atrophy, sternum hypoplasia, cleft palate, tail hypoplasia, absence of the autopod, abnormal hair follicle development, and perinatal lethality.

 
Human Diseases Modeled Using Mouse Porcn (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(25)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	glycoprotein metabolic process, Wnt receptor signaling pathway
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, endoplasmic reticulum, ...
Function	protein binding, transferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (211)    Tissues (67)    Images (26)
Theiler Stages: 15, 17, 19, 20, 21, 23, 28

Assay Type	Results
RNA in situ	189
RT-PCR	14
RNase protection	8

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(2) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018131 (Evidence)
Ensembl Gene Model	ENSMUSG00000031169 (Evidence)
Entrez Gene	53627 (Evidence)
UniGene	443425
DFCI	TC1581971, TC1592988, TC1596351, TC1624483
DoTS	DT.55154857, DT.94132229
NIA Mouse Gene Index	U039244
EC	2.3.1.-
Consensus CDS Project	CCDS29990.1, CCDS29991.1, CCDS29992.1, CCDS29993.1
International Mouse Knockout Project Status	Porcn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018131	VEGA Gene Model | MGI Sequence Detail	12678	C57BL/6J
transcript	OTTMUST00000043787	VEGA | MGI Sequence Detail	1872	Not Applicable
polypeptide	OTTMUSP00000019663	VEGA | MGI Sequence Detail	461	Not Applicable

All sequences(53) RefSeq(8) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004299	Membrane bound O-acyl transferase, MBOAT
Protein Ontology	PR:000030936	protein-cysteine N-palmitoyltransferase porcupine

References

(Earliest) J:50325 Reed V, et al., Characterisation of X-linked developmental mutants with craniofacial abnormalities. 12th International Mouse Genome Conference 9/29/98 - 10/3/98, Garmisch-Pastenkerchen, Germany. 1998;:E24 (Abstr.)
(Latest) J:188364 Schwenk J, et al., High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron. 2012 May 24;74(4):621-33
All references(46)

Other accession IDs

MGI:1099441, MGI:1919237, MGI:2147986