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Porcn
Gene Detail
Symbol

Name
ID
Porcn
porcupine homolog (Drosophila)
MGI:1890212
Synonyms
2410004O13Rik, DXHXS7465e, mMg61, Mporc, porc
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:8193848-8206525 bp, - strand
From VEGA annotation of GRCm38

  12678 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Porcn

Human
homologs
Human Homolog PORCN, porcupine homolog (Drosophila)
NCBI Gene ID 64840
neXtProt AC  NX_Q9H237
Human Synonyms  DHOF, FODH, MG61, PORC, PPN
Human Chr (Location)  Xp11.23; chrX:48508959-48520814 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PORCN
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(18) Targeted(7)
 
Mice homozygous for a conditional allele activated in the epiblast exhibit abnormal mesoderm development, dermal atrophy, sternum hypoplasia, cleft palate, tail hypoplasia, absence of the autopod, abnormal hair follicle development, and perinatal lethality.
 
Human Diseases Modeled Using Mouse Porcn (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(31)
Interactions
Porcn interacts with 91 markers (Mir7-1, Mir20a, Mir92-2, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (260)    Tissues (116)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 238
RT-PCR 14
RNase protection 8
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(2) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018131 (Evidence)
Ensembl Gene ModelENSMUSG00000031169 (Evidence)
Entrez Gene53627 (Evidence)
UniGene443425
DFCITC1581971, TC1592988, TC1596351, TC1624483
DoTSDT.55154857, DT.94132229
NIA Mouse Gene IndexU039244
EC2.3.1.-
Consensus CDS ProjectCCDS29990.1, CCDS29991.1, CCDS29992.1, CCDS29993.1
International Mouse Knockout Project StatusPorcn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018131 VEGA Gene Model | MGI Sequence Detail 12678 C57BL/6J ±  kb
transcript OTTMUST00000043787 VEGA | MGI Sequence Detail 1872 Not Applicable 
polypeptide OTTMUSP00000019663 VEGA | MGI Sequence Detail 461 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(16) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
Protein Ontology PR:000030936 protein-cysteine N-palmitoyltransferase porcupine
References
(Earliest) J:50325 Reed V, et al., Characterisation of X-linked developmental mutants with craniofacial abnormalities. 12th International Mouse Genome Conference 9/29/98 - 10/3/98, Garmisch-Pastenkerchen, Germany. 1998;:E24 (Abstr.)
(Latest) J:207465 San Roman AK, et al., Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2014 Feb 11;2(2):127-34
All references(51)
Disease annotation references (2)
Other
accession IDs
MGI:1099441, MGI:1919237, MGI:2147986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory