Phenotypes for Porcn Tg(Prrx1-cre)1Cjt MGI:5435567 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Porcn^tm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Vdv mutation (1 available); any Porcn mutation (19 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Skeletal abnormalities in Porcn^tm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0 mice

growth/size/body

decreased body size ( J:186934 )

• at P7

postnatal growth retardation ( J:186934 )

• become progressively stunted between P7 and P28

limbs/digits/tail

brachydactyly ( J:186934 )

syndactyly ( J:186934 )

• soft tissue syndactyly in some mice on both the fore- and hindlimbs

short limbs ( J:186934 )

skeleton

decreased length of long bones ( J:186934 )

• long bones of all extremities and digits are short

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:186934

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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