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Phenotypes Associated with This Genotype
Genotype
MGI:5435562
Allelic
Composition		 Porcntm1.1Vdv/Y
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Vdv mutation (1 available); any Porcn mutation (19 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:186934 )
• out of 13 litters only 3 males were recovered and these had a low level of mosaicism

integument
abnormal hair growth ( J:186934 )
• decreased hair growth in survivors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
focal dermal hypoplasia DOID:2120 OMIM:305600
 J:186934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory