Adar
Gene Detail

Symbol Name ID

Adar adenosine deaminase, RNA-specific MGI:1889575

Synonyms

ADAR1, mZaADAR

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.19 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:89715022-89753446 bp, + strand From VEGA annotation of GRCm38   38425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: double-stranded RNA-specific adenosine deaminase
Gene Tree: Adar

Human homologs

Human Homolog		ADAR, adenosine deaminase, RNA-specific
NCBI Gene ID		103
neXtProt AC		NX_P55265
Human Synonyms		ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI4, IFI-4, K88DSRBP, P136
Human Chr (Location)		1q21.3; chr1:154554533-154600456 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ADAR

Alleles and phenotypes

All alleles(33) : Targeted(8) Gene trapped(25)
 

Homozygous null mice die during gestation. Inactivation of this locus has been associated with increased apoptosis and, in some lines, defects in both primitive and definitive hematopoiesis.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	adenosine to inosine editing, base conversion or substitution editing, ...
Component	cytoplasm, nucleolus, ...
Function	adenosine deaminase activity, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (209)    Tissues (154)    Images (60)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	201
RT-PCR	2

cDNA source data(161)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(165) Genomic(1) cDNA(162) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000020280 (Evidence)
Ensembl Gene Model	ENSMUSG00000027951 (Evidence)
Entrez Gene	56417 (Evidence)
UniGene	316628
DFCI	TC1574591, TC1584283
DoTS	DT.101397482, DT.101397485, DT.494187, DT.91578161, DT.97409471
NIA Mouse Gene Index	U042455
EC	3.5.4.-
Consensus CDS Project	CCDS17513.1, CCDS17514.1, CCDS50963.1
International Mouse Knockout Project Status	Adar

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020280	VEGA Gene Model | MGI Sequence Detail	38425	C57BL/6J
transcript	OTTMUST00000048132	VEGA | MGI Sequence Detail	5871	Not Applicable
polypeptide	OTTMUSP00000021977	VEGA | MGI Sequence Detail	1178	Not Applicable

All sequences(75) RefSeq(6) UniProt(7)

Polymorphisms

SNPs within 2kb(181 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002466	Adenosine deaminase/editase
InterPro	IPR014720	Double-stranded RNA-binding domain
InterPro	IPR000607	Double-stranded RNA-specific adenosine deaminase (DRADA)
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000003745	double-stranded RNA-specific adenosine deaminase

References

(Earliest) J:64308 Weier HU, et al., Assignment of the RNA-specific adenosine deaminase gene (Adar) to mouse chromosome 3F2 by in situ hybridization. Cytogenet Cell Genet. 2000;89(3-4):214-5
(Latest) J:193867 Tsuruoka N, et al., ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells. J Biol Chem. 2013 Jan 11;288(2):826-36
All references(57)

Other accession IDs

MGI:2139942