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Adar Gene Detail
Summary
  • Symbol
    Adar
  • Name
    adenosine deaminase, RNA-specific
  • Synonyms
    ADAR1, Adar1p110, Adar1p150, mZaADAR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889575
    NCBI Gene: 56417
  • Gene Overview
    MyGene.info: ADAR
Location & Maps
more
  • Sequence Map
    Chr3:89715022-89753446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.19 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAR, adenosine deaminase, RNA specific
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAR, adenosine deaminase, RNA specific
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI4, IFI-4, K88DSRBP, P136
  • Links
    NCBI Gene ID: 103
    neXtProt AC: NX_P55265

  • Chr Location
    1q21.3; chr1:154582057-154628013 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ADAR associations

Human Disease Mouse Models
       Aicardi-Goutieres Syndrome 6; AGS6   OMIM: 615010
Dyschromatosis Symmetrica Hereditaria; DSH   OMIM: 127400
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 8 alleles in 9 genetic backgrounds
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Adar
  • Incidental Mutations
Homozygous null mice die during gestation. Inactivation of this locus has been associated with increased apoptosis and, in some lines, defects in both primitive and definitive hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020280 VEGA Gene Model | MGI Sequence Detail 38425 C57BL/6J ±  kb
transcript OTTMUST00000048132 VEGA | MGI Sequence Detail 5871 Not Applicable  
polypeptide OTTMUSP00000021977 VEGA | MGI Sequence Detail 1178 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    181 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000003745 double-stranded RNA-specific adenosine deaminase
  • EC
  • InterPro Domains
    IPR002466 Adenosine deaminase/editase
    IPR014720 Double-stranded RNA-binding domain
    IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA)
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 164
    Genomic 1
    cDNA 161
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2139942
References
more
  • Summaries
    All 62
    Developmental Gene Expression 12
    Gene Ontology 21
    Phenotypes 25
  • Earliest
    J:64308 Weier HU, et al., Assignment of the RNA-specific adenosine deaminase gene (Adar) to mouse chromosome 3F2 by in situ hybridization. Cytogenet Cell Genet. 2000;89(3-4):214-5
  • Latest
    J:231313 George CX, et al., Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses. J Biol Chem. 2016 Mar 18;291(12):6158-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory