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Adar Gene Detail
Summary
  • Symbol
    Adar
  • Name
    adenosine deaminase, RNA-specific
  • Synonyms
    ADAR1, Adar1p110, Adar1p150, mZaADAR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889575
    NCBI Gene: 56417
  • Gene Overview
    MyGene.info: ADAR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:89715022-89753446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.19 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAR, adenosine deaminase, RNA specific
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAR, adenosine deaminase, RNA specific
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI4, IFI-4, K88DSRBP, P136
  • Links
    NCBI Gene ID: 103
    neXtProt AC: NX_P55265
    UniProt: P55265

  • Chr Location
    1q21.3; chr1:154582057-154628016 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human ADAR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 8 alleles in 9 genetic backgrounds
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice die during gestation. Inactivation of this locus has been associated with increased apoptosis and, in some lines, defects in both primitive and definitive hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020280 VEGA Gene Model | MGI Sequence Detail 38425 C57BL/6J ±  kb
    transcript OTTMUST00000048132 VEGA | MGI Sequence Detail 5871 Not Applicable  
    polypeptide OTTMUSP00000021977 VEGA | MGI Sequence Detail 1178 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      181 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 165
      Genomic 1
      cDNA 162
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139942
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 23
      Phenotypes 31
    • Earliest
      J:64308 Weier HU, et al., Assignment of the RNA-specific adenosine deaminase gene (Adar) to mouse chromosome 3F2 by in situ hybridization. Cytogenet Cell Genet. 2000;89(3-4):214-5
    • Latest
      J:243912 Snyder EM, et al., Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1. Biol Reprod. 2017 Jan 01;96(1):244-253

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory