Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in adenosine to inosine editing; cellular response to virus; and positive regulation of viral genome replication. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; hemopoiesis; and regulation of gene expression. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study Aicardi-Goutieres syndrome. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific).