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Gsk3b
Gene Detail
 Symbol
Name
ID
Gsk3b
glycogen synthase kinase 3 beta
MGI:1861437
Synonyms 7330414F15Rik, 8430431H08Rik, GSK3, GSK-3, GSK-3beta
Feature Type protein coding gene
Genetic Map
Chromosome 16
26.54 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:38089001-38246084 bp, + strand
From VEGA annotation of GRCm38

  157084 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Gsk3b

Human
homologs
Human Homolog GSK3B, glycogen synthase kinase 3 beta
NCBI Gene ID 2932
neXtProt AC  NX_P49841
Human Chr (Location)  3q13.3; chr3:119821321-120094417 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(130) : Gene trapped(117) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Gsk3b interacts with 505 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (139 annotations)
Process axonogenesis, canonical Wnt signaling pathway, ...
Component beta-catenin destruction complex, cell body, ...
Function ATP binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (407)    Tissues (178)    Images (160)
Theiler Stages: 1, 2, 3, 5, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 135
In situ reporter (knock in) 143
Western blot 52
RT-PCR 74
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016276 (Evidence)
Ensembl Gene ModelENSMUSG00000022812 (Evidence)
Entrez Gene56637 (Evidence)
DFCITC1579305, TC1616105, TC1659348, TC1661346
EC2.7.11.1, 2.7.11.26
PDB4NU1
Consensus CDS ProjectCCDS28163.1
International Mouse Knockout Project StatusGsk3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016276 VEGA Gene Model | MGI Sequence Detail 157084 C57BL/6J ±  kb
transcript OTTMUST00000039049 VEGA | MGI Sequence Detail 1750 Not Applicable 
polypeptide OTTMUSP00000017446 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(764 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008288 glycogen synthase kinase-3 beta
References (Earliest) J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
(Latest) J:211860 Zhang BY, et al., Akt-independent GSK3 inactivation downstream of PI3K signaling regulates mammalian axon regeneration. Biochem Biophys Res Commun. 2014 Jan 10;443(2):743-8
All references(300)
Other
accession IDs
MGI:1914056, MGI:1925394, MGI:2146721

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory