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Gsk3b
Gene Detail
Symbol

Name
ID
Gsk3b
glycogen synthase kinase 3 beta
MGI:1861437
Synonyms
7330414F15Rik, 8430431H08Rik, GSK3, GSK-3, GSK-3beta
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.54 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:38089001-38246084 bp, + strand
From VEGA annotation of GRCm38

  157084 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GSK3B
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Gsk3b

Human
homologs
GSK3B, glycogen synthase kinase 3 beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2932
neXtProt AC: NX_P49841

Human Chr (Location): 3q13.3; chr3:119821321-120094417 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(131) : Gene trapped(117) Targeted(13) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Gsk3b interacts with 504 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (161 annotations)
Process axonogenesis, canonical Wnt signaling pathway, ...
Component axon, beta-catenin destruction complex, ...
Function ATP binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (417)    Tissues (181)    Images (164)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 145
In situ reporter (knock in) 143
Western blot 52
RT-PCR 74
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gsk3b ; ZFIN gsk3b    NEW 
Molecular
reagents
All nucleic(21) cDNA(17) Primer pair(2) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016276 (Evidence)
Ensembl Gene Model ENSMUSG00000022812 (Evidence)
Entrez Gene 56637 (Evidence)
DFCI TC1661346, TC1659348, TC1579305, TC1616105
EC 2.7.11.1, 2.7.11.26
PDB 4NU1, 5AIR
Consensus CDS Project CCDS28163.1
International Mouse Phenotyping Consortium Status Gsk3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016276 VEGA Gene Model | MGI Sequence Detail 157084 C57BL/6J ±  kb
transcript OTTMUST00000039049 VEGA | MGI Sequence Detail 1750 Not Applicable 
polypeptide OTTMUSP00000017446 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(764 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008288 glycogen synthase kinase-3 beta
References
(Earliest) J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
(Latest) J:221208 Laurent PA, et al., Platelet PI3Kbeta and GSK3 regulate thrombus stability at a high shear rate. Blood. 2015 Jan 29;125(5):881-8
All references(323)
Other
accession IDs
MGI:1914056, MGI:1925394, MGI:2146721

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory