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Gsk3b Gene Detail
Summary
  • Symbol
    Gsk3b
  • Name
    glycogen synthase kinase 3 beta
  • Synonyms
    7330414F15Rik, 8430431H08Rik, GSK3, GSK-3, GSK-3beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861437
    NCBI Gene: 56637
  • Gene Overview
    MyGene.info: GSK3B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:38089001-38246084 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      157084 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.54 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GSK3B, glycogen synthase kinase 3 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSK3B, glycogen synthase kinase 3 beta
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2932
    neXtProt AC: NX_P49841
    UniProt: P49841

  • Chr Location
    3q13.33; chr3:119821321-120094417 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 9 alleles in 15 genetic backgrounds
    33 phenotypes from multigenic genotypes
    2 images
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016276 VEGA Gene Model | MGI Sequence Detail 157084 C57BL/6J ±  kb
    transcript OTTMUST00000039049 VEGA | MGI Sequence Detail 1750 Not Applicable  
    polypeptide OTTMUSP00000017446 VEGA | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      751 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 18
      Primer pair 3
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914056, MGI:1925394, MGI:2146721
    References
    more
    • Summaries
      All 493
      Developmental Gene Expression 94
      Diseases 1
      Gene Ontology 55
      Phenotypes 117
    • Earliest
      J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
    • Latest
      J:263276 Gonzalez-Fernandez E, et al., PTEN negatively regulates the cell lineage progression from NG2(+) glial progenitor to oligodendrocyte via mTOR-independent signaling. Elife. 2018 Feb 20;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory