Gsk3b
Gene Detail

Symbol Name ID

Gsk3b glycogen synthase kinase 3 beta MGI:1861437

Synonyms

7330414F15Rik, 8430431H08Rik, GSK3, GSK-3, GSK-3beta

Feature Type

protein coding gene

Genetic Map

Chromosome 16

26.54 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:38089001-38246084 bp, + strand From VEGA annotation of GRCm38   157084 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gsk3b ± 2 cM)

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Gsk3b

Human ortholog

GSK3B glycogen synthase kinase 3 beta NCBI Gene ID 2932
Human Chr3:119540800-119813264 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(130) : Targeted(13) Gene trapped(117)
 

Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (122 annotations)

Process	axonogenesis, canonical Wnt receptor signaling pathway, ...
Component	beta-catenin destruction complex, centrosome, ...
Function	ATP binding, beta-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (62 records)
Data Summary: Results (389)    Tissues (169)    Images (147)
Theiler Stages: 1, 2, 3, 5, 19, 20, 21, 23, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	135
In situ reporter (knock in)	131
Western blot	46
RT-PCR	74

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016276 (Evidence)
Ensembl Gene Model	ENSMUSG00000022812 (Evidence)
Entrez Gene	56637 (Evidence)
DFCI	TC1579305, TC1616105, TC1659348, TC1661346
EC	2.7.11.1, 2.7.11.26
Consensus CDS Project	CCDS28163.1
International Mouse Knockout Project Status	Gsk3b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016276	VEGA Gene Model | MGI Sequence Detail	157084	C57BL/6J
transcript	OTTMUST00000039049	VEGA | MGI Sequence Detail	1750	Not Applicable
polypeptide	OTTMUSP00000017446	VEGA | MGI Sequence Detail	433	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(660 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008288	glycogen synthase kinase-3 beta

References

(Earliest) J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
(Latest) J:192749 Mazzardo-Martins L, et al., Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action. Neuroscience. 2012 Dec 13;226:411-20
All references(267)

Other accession IDs

MGI:1914056, MGI:1925394, MGI:2146721