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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gsk3b
glycogen synthase kinase 3 beta
MGI:1861437
51 phenotypes from 9 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gsk3btm1.1Atak/Gsk3b+
involves: C57BL/6
abnormal bone healing J:211406
abnormal contextual conditioning behavior J:144055
abnormal learning/memory/conditioning J:144055
abnormal skeleton development J:211406
abnormal spatial reference memory J:144055
normal behavior/neurological phenotype J:144055
increased compact bone volume J:211406
increased trabecular bone volume J:211406
Gsk3btm1.1Ypc/Gsk3btm1.1Ypc
Osr2tm2(cre)Jian/Osr2+
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
normal craniofacial phenotype J:166721
normal mortality/aging J:166721
Gsk3btm1.1Ypc/Gsk3btm1.1Ypc
Tg(Pitx2-cre)1Ych/0
involves: 129S4/SvJaeSor * C57BL/6
cleft secondary palate J:166721
failure of palatal shelf elevation J:166721
palatal shelves fail to meet at midline J:166721
Gsk3btm1.2Ypc/Gsk3btm1.2Ypc
involves: 129S4/SvJaeSor * C57BL/6 * CBA
abnormal palate development J:166721
complete cleft palate J:166721
failure of palatal shelf elevation J:166721
neonatal lethality, complete penetrance J:166721
palatal shelves fail to meet at midline J:166721
Gsk3btm1Dgen/Gsk3b+
involves: 129P2/OlaHsd * C57BL/6
no abnormal phenotype detected J:101679
Gsk3btm1Dgen/Gsk3btm1Dgen
involves: 129P2/OlaHsd * C57BL/6
preweaning lethality, complete penetrance J:101679
Gsk3btm1Dral/Gsk3btm1Dral
involves: 129P2/OlaHsd
decreased myocardial infarct size J:186597
decreased P wave amplitude J:235770
increased myocardial infarct size J:186597
prolonged PR interval J:235770
Gsk3btm1Dral/Gsk3btm1Dral
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal glycogen homeostasis J:98263
normal homeostasis/metabolism phenotype J:98263
Gsk3btm1Grc/Gsk3b+
involves: 129S6/SvEvTac
decreased myocardial infarct size J:186597
increased myocardial infarct size J:186597
Gsk3btm1Grc/Gsk3btm1Grc
involves: 129S6/SvEvTac * CD-1
abnormal sternum ossification J:119186
cleft secondary palate J:119186
delayed bone ossification J:119186
neonatal lethality, complete penetrance J:119186
palatal shelves fail to meet at midline J:119186
split sternum J:119186
xiphoid process foramen J:119186
Gsk3btm1Grc/Gsk3btm1Jrw
involves: 129 * 129S6/SvEvTac * CD-1
abnormal sternum ossification J:119186
cleft secondary palate J:119186
delayed bone ossification J:119186
neonatal lethality, complete penetrance J:119186
palatal shelves fail to meet at midline J:119186
split sternum J:119186
xiphoid process foramen J:119186
Gsk3btm1Jrw/Gsk3b+
involves: 129 * C57BL/6
abnormal osteoblast physiology J:129364
abnormal skeleton physiology J:129364
enhanced osteoblast differentiation J:129364
increased bone mass J:129364
increased bone ossification J:129364
increased bone resorption J:129364
increased compact bone mass J:129364
increased compact bone thickness J:129364
increased trabecular bone mass J:129364
increased trabecular bone volume J:129364
Gsk3btm1Jrw/Gsk3b+
involves: 129 * C57BL/6J
abnormal glucose homeostasis J:135659
behavioral despair J:97268
decreased circulating glucose level J:135659
decreased circulating insulin level J:135659
decreased exploration in new environment J:97268
decreased prepulse inhibition J:161844
Gsk3btm1Jrw/Gsk3btm1Jrw
involves: 129 * C57BL/6J
abnormal hepatocyte morphology J:63274
abnormal liver morphology J:63274
lethality throughout fetal growth and development, complete penetrance J:63274
Gsk3btm1Jrw/Gsk3btm1Jrw
involves: 129 * CD-1
abnormal sternum ossification J:119186
cleft secondary palate J:119186
delayed bone ossification J:119186
neonatal lethality, complete penetrance J:119186
palatal shelves fail to meet at midline J:119186
split sternum J:119186
xiphoid process foramen J:119186
Gsk3btm2Jrw/Gsk3btm2Jrw
Tg(Ggt1-cre)M3Egn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
abnormal proximal convoluted tubule morphology J:167190
abnormal renal tubule morphology J:167190
increased glycogen level J:167190
normal renal/urinary system phenotype J:167190
Gsk3btm2138.1Arte/Gsk3btm2138.1Arte
C57BL/6-Gsk3btm2138.1Arte
abnormal Wallerian degeneration J:188272

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory