Gene Expression Literature Summary

• Symbol: Gsk3b
• Name: glycogen synthase kinase 3 beta
• ID: MGI:1861437

132 matching records from 132 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)								1				2		4		9		5		5		3	1	2		3	1			7
In situ RNA (section)												2		3		3		3		4		1				1				2
Immunohistochemistry (whole mount)	1
In situ reporter (knock in)							1	1								1			1											2
Western blot	1	1		1		1	1	1	1	3	1	4	2	6	1	13	3	15	1	5	3	6	3	7	3	9	1	1	2	41
RT-PCR			2	1	1			1				1		3		3		3		3		1		3		3			1	8
cDNA clones																							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gsk3b  glycogen synthase kinase 3 beta   (Synonyms: 7330414F15Rik, 8430431H08Rik, GSK3, GSK-3, GSK-3beta)
Results	Reference
6*	J:119964 Acevedo N, Wang X, Dunn RL, Smith GD, Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos. Mol Reprod Dev. 2007 Feb;74(2):178-88
1	J:228507 Ajima R, Bisson JA, Helt JC, Nakaya MA, Habas R, Tessarollo L, He X, Morrisey EE, Yamaguchi TP, Cohen ED, DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39
2	J:114098 Armentano M, Filosa A, Andolfi G, Studer M, COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth. Development. 2006 Nov;133(21):4151-62
1*	J:161843 Asada N, Sanada K, LKB1-mediated spatial control of GSK3beta and adenomatous polyposis coli contributes to centrosomal forward movement and neuronal migration in the developing neocortex. J Neurosci. 2010 Jun 30;30(26):8852-65
1	J:85994 Aszodi A, Hunziker EB, Brakebusch C, Fassler R, Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 2003 Oct 1;17(19):2465-79
6*	J:195008 Barrell WB, Szabo-Rogers HL, Liu KJ, Novel reporter alleles of GSK-3alpha and GSK-3beta. PLoS One. 2012;7(11):e50422
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:236179 Bowman CE, Zhao L, Hartung T, Wolfgang MJ, Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104
1	J:334838 Chang JH, Chou CH, Wu JC, Liao KM, Luo WJ, Hsu WL, Chen XR, Yu SL, Pan SH, Yang PC, Su KY, LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway. Commun Biol. 2023 Apr 10;6(1):389
3	J:183920 Chen J, Lai F, Niswander L, The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
1	J:282264 Chen P, Zhang T, Yuan Z, Shen B, Chen L, Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex. Mol Brain. 2019 Aug 28;12(1):74
1	J:343798 Cheng T, Agwu C, Shim K, Wang B, Jain S, Mahjoub MR, Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease. Development. 2023 Dec 15;150(24)
1	J:272052 Cheng X, Ma X, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q, Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol Cell. 2019 Feb 21;73(4):788-802.e7
1	J:299855 Cheng YY, Chou YT, Lai FJ, Jan MS, Chang TH, Jou IM, Chen PS, Lo JY, Huang SS, Chang NS, Liou YT, Hsu PC, Cheng HC, Lin YS, Hsu LJ, Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3beta-mediated epileptic seizure activity in mice. Acta Neuropathol Commun. 2020 Jan 30;8(1):6
1	J:302676 Cheong H, Wu J, Gonzales LK, Guttentag SH, Thompson CB, Lindsten T, Analysis of a lung defect in autophagy-deficient mouse strains. Autophagy. 2014 Jan;10(1):45-56
1*	J:152211 Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P, Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia. 2009 Oct;57(13):1450-7
1	J:186340 Croci L, Barili V, Chia D, Massimino L, van Vugt R, Masserdotti G, Longhi R, Rotwein P, Consalez GG, Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth. Cell Death Differ. 2011 Jan;18(1):48-59
1	J:205269 Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW, Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
1	J:312371 Da Silva F, Zhang K, Pinson A, Fatti E, Wilsch-Brauninger M, Herbst J, Vidal V, Schedl A, Huttner WB, Niehrs C, Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
2	J:241786 Darwich R, Li W, Yamak A, Komati H, Andelfinger G, Sun K, Nemer M, KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5. Hum Mol Genet. 2017 Mar 01;26(5):942-954
1	J:167834 Dawe CE, Kooistra MK, Fairbridge NA, Pisio AC, McDermid HE, Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dev Dyn. 2011 Feb;240(2):372-83
1	J:317793 De Zio D, Molinari F, Rizza S, Gatta L, Ciotti MT, Salvatore AM, Mathiassen SG, Cwetsch AW, Filomeni G, Rosano G, Ferraro E, Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015 Nov;72(21):4173-91
6*	J:228948 Deak VA, Skroblin P, Dittmayer C, Knobeloch KP, Bachmann S, Klussmann E, The A-kinase Anchoring Protein GSKIP Regulates GSK3beta Activity and Controls Palatal Shelf Fusion in Mice. J Biol Chem. 2016 Jan 8;291(2):681-90
2*	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
1	J:96826 Di-Poi N, Ng CY, Tan NS, Yang Z, Hemmings BA, Desvergne B, Michalik L, Wahli W, Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol. 2005 Mar;25(5):1696-712
1	J:142531 Diaz-Ruiz C, Parlato R, Aguado F, Urena JM, Burgaya F, Martinez A, Carmona MA, Kreiner G, Bleckmann S, Del Rio JA, Schutz G, Soriano E, Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants. Mol Cell Neurosci. 2008 Dec;39(4):519-28
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:242729 Ding X, Bloch W, Iden S, Ruegg MA, Hall MN, Leptin M, Partridge L, Eming SA, mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226
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3*	J:279271 Ellis K, Driver EC, Okano T, Lemons A, Kelley MW, GSK3 regulates hair cell fate in the developing mammalian cochlea. Dev Biol. 2019 Sep 15;453(2):191-205
2	J:202758 Fang WQ, Chen WW, Fu AK, Ip NY, Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex. Neuron. 2013 Aug 21;79(4):665-79
1	J:139818 Feutz AC, Barrandon Y, Monard D, Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J Cell Sci. 2008 May 1;121(Pt 9):1435-43
1	J:154243 Fischer M, Pereira PM, Holtmann B, Simon CM, Hanauer A, Heisenberg M, Sendtner M, P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons. Mol Cell Neurosci. 2009 Oct;42(2):134-41
4	J:225600 Georgy SR, Cangkrama M, Srivastava S, Partridge D, Auden A, Dworkin S, McLean CA, Jane SM, Darido C, Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma. J Natl Cancer Inst. 2015 Sep;107(9)
3	J:265720 Gonzalez Malagon SG, Lopez Munoz AM, Doro D, Bolger TG, Poon E, Tucker ER, Adel Al-Lami H, Krause M, Phiel CJ, Chesler L, Liu KJ, Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus. Nat Commun. 2018 Mar 19;9(1):1126
1	J:230653 Grego-Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson KV, The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife. 2016;5:e12034
1	J:292120 Guo Y, Sui JY, Kim K, Zhang Z, Qu XA, Nam YJ, Willette RN, Barnett JV, Knollmann BC, Force T, Lal H, Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling. Circulation. 2019 Nov 26;140(22):1820-1833
1	J:345844 Guo Y, Xiang P, Sun X, Liu W, Zhou J, Yin B, Hou L, Qiang B, Li H, Shu P, Peng X, Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
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1*	J:122362 Harwood BN, Cross SK, Radford EE, Haac BE, de Vries WN, Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos. Dev Dyn. 2008;237(4):1099-1111
2*	J:154667 Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM, Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7
2*	J:166721 He F, Popkie AP, Xiong W, Li L, Wang Y, Phiel CJ, Chen Y, Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn. 2010 Dec;239(12):3235-46
1	J:115575 Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S, The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci. 2006 Nov 15;26(46):11992-2002
1	J:175786 Ho AT, Hayashi S, Brohl D, Aurade F, Rattenbach R, Relaix F, Neural Crest Cell Lineage Restricts Skeletal Muscle Progenitor Cell Differentiation through Neuregulin1-ErbB3 Signaling. Dev Cell. 2011 Aug 16;21(2):273-87
1	J:318935 Hu Q, Lee SY, O'Kusky JR, Ye P, Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain. ASN Neuro. 2012 Jul 10;4(5)
1*	J:190241 Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algul H, Schmid RM, Chung UI, Kawaguchi H, GSK-3alpha and GSK-3beta proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation. J Biol Chem. 2012 Aug 24;287(35):29227-36
1	J:341690 Ji F, Feng C, Qin J, Wang C, Zhang D, Su L, Wang W, Zhang M, Li H, Ma L, Lu W, Liu C, Teng Z, Hu B, Jian F, Xie J, Jiao J, Brain-specific Pd1 deficiency leads to cortical neurogenesis defects and depressive-like behaviors in mice. Cell Death Differ. 2023 Sep;30(9):2053-2065
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1	J:216503 Ka M, Jung EM, Mueller U, Kim WY, MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling. Dev Biol. 2014 Nov 1;395(1):4-18
1*	J:95815 Kang JO, Sucov HM, Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development. Mech Dev. 2005 Jan;122(1):57-65
2	J:197212 Kim HJ, Woo HM, Ryu J, Bok J, Kim JW, Choi SB, Park MH, Park HY, Koo SK, Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS One. 2013;8(2):e55609
1	J:327072 Kim WK, Olson AW, Mi J, Wang J, Lee DH, Le V, Hiroto A, Aldahl J, Nenninger CH, Buckley AJ, Cardiff R, You S, Sun Z, Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes. Nat Commun. 2022 Jul 28;13(1):4364
3	J:154623 Kim WY, Wang X, Wu Y, Doble BW, Patel S, Woodgett JR, Snider WD, GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci. 2009 Nov;12(11):1390-7
4	J:122936 Kim WY, Zhou FQ, Zhou J, Yokota Y, Wang YM, Yoshimura T, Kaibuchi K, Woodgett JR, Anton ES, Snider WD, Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron. 2006 Dec 21;52(6):981-96
3	J:312458 Kisseleff E, Vigouroux RJ, Hottin C, Lourdel S, Thomas L, Shah P, Chedotal A, Perron M, Swaroop A, Roger JE, Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced Retinal Ganglion Cells3. eNeuro. 2021 Sep-Oct;8(5):ENEURO.0171-21.2021
2	J:191495 Kucerova R, Dora N, Mort RL, Wallace K, Leiper LJ, Lowes C, Neves C, Walczysko P, Bruce F, Fowler PA, Rajnicek AM, McCaig CD, Zhao M, West JD, Collinson JM, Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium. Mol Vis. 2012;18:139-50
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1	J:277244 LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V, Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24;12(6):dmm036764
1	J:154054 Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R, Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 2009 Oct 15;461(7266):1002-6
1*	J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
4	J:209602 Li CL, Sathyamurthy A, Oldenborg A, Tank D, Ramanan N, SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014 Mar 12;34(11):4027-42
8	J:185188 Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, Wallace V, Dilworth FJ, Brand M, Schuurmans C, GSK3 Temporally Regulates Neurogenin 2 Proneural Activity in the Neocortex. J Neurosci. 2012 Jun 6;32(23):7791-805
1	J:201649 Li Y, Liu J, McLaughlin N, Bachvarov D, Saifudeen Z, El-Dahr SS, Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney. Physiol Genomics. 2013 Oct 16;45(20):948-64
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1	J:147568 Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH, Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009 Mar 20;136(6):1017-31
1	J:290858 Marchant C, Anderson P, Schwarz Q, Wiszniak S, Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis. Development. 2020 Jun 11;147(11):dev190488
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1	J:258679 Mirzaa G, Parry DA, Fry AE, Giamanco KA, Schwartzentruber J, Vanstone M, Logan CV, Roberts N, Johnson CA, Singh S, Kholmanskikh SS, Adams C, Hodge RD, Hevner RF, Bonthron DT, Braun KPJ, Faivre L, Riviere JB, St-Onge J, Gripp KW, Mancini GM, Pang K, Sweeney E, van Esch H, Verbeek N, Wieczorek D, Steinraths M, Majewski J, Boycot KM, Pilz DT, Ross ME, Dobyns WB, Sheridan EG, De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Nat Genet. 2014 May;46(5):510-515
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2	J:175706 Musselmann K, Green JA, Sone K, Hsu JC, Bothwell IR, Johnson SA, Harunaga JS, Wei Z, Yamada KM, Salivary gland gene expression atlas identifies a new regulator of branching morphogenesis. J Dent Res. 2011 Sep;90(9):1078-84
1	J:100025 Niewmierzycka A, Mills J, St-Arnaud R, Dedhar S, Reichardt LF, Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. J Neurosci. 2005 Jul 27;25(30):7022-31
1*	J:323188 Nomura T, Gotoh H, Kiyonari H, Ono K, Cell Type-Specific Transcriptional Control of Gsk3beta in the Developing Mammalian Neocortex. Front Neurosci. 2022;16:811689
1	J:213126 O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
3*	J:311540 Oliver BL, Young CA, Munnamalai V, Spatial and temporal expression of PORCN is highly dynamic in the developing mouse cochlea. Gene Expr Patterns. 2021 Sep 20;42:119214
1	J:258274 Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ, Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018 Feb 22;7(2):bio032094
1	J:163221 Pereira JA, Benninger Y, Baumann R, Goncalves AF, Ozcelik M, Thurnherr T, Tricaud N, Meijer D, Fassler R, Suter U, Relvas JB, Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol. 2009 Apr 6;185(1):147-61
1	J:149326 Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ, A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet. 2009 Jul 1;18(13):2378-87
2	J:255488 Premarathne S, Murtaza M, Matigian N, Jolly LA, Wood SA, Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109
1*	J:253620 Pryce BR, Al-Zahrani KN, Dufresne S, Belkina N, Labreche C, Patino-Lopez G, Frenette J, Shaw S, Sabourin LA, Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017 Feb 2;7(1):3
1	J:208504 Qiao L, Yoo HS, Madon A, Kinney B, Hay WW Jr, Shao J, Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012 Dec;61(12):3199-207
1	J:314161 Rashidieh B, Shohayeb B, Bain AL, Fortuna PRJ, Sinha D, Burgess A, Mills R, Adams RC, Lopez JA, Blumbergs P, Finnie J, Kalimutho M, Piper M, Hudson JE, Ng DCH, Khanna KK, Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis. PLoS Genet. 2021 Oct;17(10):e1009334
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