Stk39
Gene Detail

Symbol Name ID

Stk39 serine/threonine kinase 39 MGI:1858416

Synonyms

DCHT, RF005, Rnl5, SPAK

Feature Type

protein coding gene

Genetic Map

Chromosome 2

39.53 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:68210445-68472268 bp, - strand From VEGA annotation of GRCm38   261824 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Stk39

Human homologs

Human Homolog		STK39, serine threonine kinase 39
NCBI Gene ID		27347
neXtProt AC		NX_Q9UEW8
Human Synonyms		DCHT, PASK, SPAK
Human Chr (Location)		2q24.3; chr2:167954020-168247595 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.

 
Human Diseases Modeled Using Mouse Stk39 (1)    Alleles Annotated to Human Diseases(1)   

Interactions

Stk39 interacts with 270 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	intracellular signal transduction, negative regulation of potassium ion transmembrane transport, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (60)    Tissues (15)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Immunohistochemistry	14
Western blot	35
RT-PCR	11

cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000012975 (Evidence)
Ensembl Gene Model	ENSMUSG00000027030 (Evidence)
Entrez Gene	53416 (Evidence)
UniGene	198414
DFCI	TC1575553
DoTS	DT.101390161, DT.488792, DT.94353291
NIA Mouse Gene Index	U022703
EC	2.7.11.1
Consensus CDS Project	CCDS16084.1
International Mouse Knockout Project Status	Stk39

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012975	VEGA Gene Model | MGI Sequence Detail	261824	C57BL/6J
transcript	OTTMUST00000031247	VEGA | MGI Sequence Detail	3536	Not Applicable
polypeptide	OTTMUSP00000013981	VEGA | MGI Sequence Detail	556	Not Applicable

All sequences(56) RefSeq(11) UniProt(5)

Polymorphisms

SNPs within 2kb(2249 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology	PR:000015756	STE20/SPS1-related proline-alanine-rich protein kinase

References

(Earliest) J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
(Latest) J:205045 Gamba G, Regulation of NKCC2 activity by SPAK truncated isoforms. Am J Physiol Renal Physiol. 2014 Jan;306(1):F49-50
All references(51)
Disease annotation references (2)

Other accession IDs

MGI:2139330, MGI:2139399, MGI:3844884