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Stk39
Gene Detail
Symbol

Name
ID
Stk39
serine/threonine kinase 39
MGI:1858416
Synonyms
DCHT, RF005, Rnl5, SPAK
Feature Type
protein coding gene
Genetic Map
Chromosome 2
39.53 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:68210445-68472268 bp, - strand
From VEGA annotation of GRCm38

  261824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: STK39
Gene Tree: Stk39

Human
homologs
STK39, serine threonine kinase 39
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27347
neXtProt AC: NX_Q9UEW8

Human Synonyms: DCHT, PASK, SPAK

Human Chr (Location): 2q24.3; chr2:167954020-168247595 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.
 
Human Diseases Modeled in Mice Using Stk39 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Stk39 interacts with 269 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process activation of protein kinase activity, cellular hypotonic response, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (60)    Tissues (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
Western blot 35
RT-PCR 11
cDNA source data(98)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stk39    NEW 
Molecular
reagents
All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000012975 (Evidence)
Ensembl Gene Model ENSMUSG00000027030 (Evidence)
Entrez Gene 53416 (Evidence)
UniGene 198414
DFCI TC1575553
DoTS DT.101390161, DT.94353291, DT.488792
NIA Mouse Gene Index U022703
EC 2.7.11.1
Consensus CDS Project CCDS16084.1
International Mouse Phenotyping Consortium Status Stk39
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012975 VEGA Gene Model | MGI Sequence Detail 261824 C57BL/6J ±  kb
transcript OTTMUST00000031247 VEGA | MGI Sequence Detail 3536 Not Applicable 
polypeptide OTTMUSP00000013981 VEGA | MGI Sequence Detail 556 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(11) UniProt(5)
Polymorphisms
SNPs within 2kb(2249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000015756 STE20/SPS1-related proline-alanine-rich protein kinase
References
(Earliest) J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
(Latest) J:219977 Terker AS, et al., Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab. 2015 Jan 6;21(1):39-50
All references(55)
Disease annotation references (2)
Other
accession IDs
MGI:2139330, MGI:2139399, MGI:3844884

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory