About   Help   FAQ
Stk39
Gene Detail
 Symbol
Name
ID
Stk39
serine/threonine kinase 39
MGI:1858416
Synonyms DCHT, RF005, Rnl5, SPAK
Feature Type protein coding gene
Genetic Map
Chromosome 2
39.53 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:68210445-68472268 bp, - strand
From VEGA annotation of GRCm38

  261824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Stk39

Human
homologs
Human Homolog STK39, serine threonine kinase 39
NCBI Gene ID 27347
neXtProt AC  NX_Q9UEW8
Human Synonyms  DCHT, PASK, SPAK
Human Chr (Location)  2q24.3; chr2:167954020-168247595 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.
 
Human Diseases Modeled Using Mouse Stk39 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Stk39 interacts with 270 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cellular hypotonic response, intracellular signal transduction, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (60)    Tissues (15)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 14
Western blot 35
RT-PCR 11
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000012975 (Evidence)
Ensembl Gene ModelENSMUSG00000027030 (Evidence)
Entrez Gene53416 (Evidence)
UniGene198414
DFCITC1575553
DoTSDT.488792, DT.101390161, DT.94353291
NIA Mouse Gene IndexU022703
EC2.7.11.1
Consensus CDS ProjectCCDS16084.1
International Mouse Knockout Project StatusStk39
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012975 VEGA Gene Model | MGI Sequence Detail 261824 C57BL/6J ±  kb
transcript OTTMUST00000031247 VEGA | MGI Sequence Detail 3536 Not Applicable 
polypeptide OTTMUSP00000013981 VEGA | MGI Sequence Detail 556 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(11) UniProt(5)
Polymorphisms SNPs within 2kb(2249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000015756 STE20/SPS1-related proline-alanine-rich protein kinase
References (Earliest) J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
(Latest) J:211319 de Los Heros P, et al., The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. Biochem J. 2014 Mar 15;458(3):559-73
All references(53)
Disease annotation references (2)
Other
accession IDs
MGI:2139330, MGI:2139399, MGI:3844884

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory