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Stk39 Gene Detail
Summary
  • Symbol
    Stk39
  • Name
    serine/threonine kinase 39
  • Synonyms
    DCHT, RF005, Rnl5, SPAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858416
    NCBI Gene: 53416
  • Gene Overview
    MyGene.info: STK39
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:68210445-68472268 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      261824 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.53 cM, cytoband C3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    STK39, serine/threonine kinase 39
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STK39, serine/threonine kinase 39
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCHT, PASK, SPAK
  • Links
    NCBI Gene ID: 27347
    neXtProt AC: NX_Q9UEW8
    UniProt: Q9UEW8

  • Chr Location
    2q24.3; chr2:167954020-168247595 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Stk39 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    60
  • Tissues
    15
  • cDNA Data
    99
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012975 VEGA Gene Model | MGI Sequence Detail 261824 C57BL/6J ±  kb
    transcript OTTMUST00000031247 VEGA | MGI Sequence Detail 3536 Not Applicable  
    polypeptide OTTMUSP00000013981 VEGA | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2239 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 99
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139330, MGI:2139399, MGI:3844884
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 14
      Phenotypes 25
    • Earliest
      J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
    • Latest
      J:263369 Rafael C, et al., Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4. Sci Rep. 2018 Feb 19;8(1):3249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory