Stk39 MGI Mouse Gene Detail - MGI:1858416 - serine/threonine kinase 39

Stk39 Gene Detail

Symbol

Stk39
Name

serine/threonine kinase 39
Synonyms

DCHT, RF005, Rnl5, SPAK

Feature Type

protein coding gene
IDs

MGI:1858416
NCBI Gene: 53416
Gene Overview

MyGene.info: STK39

Sequence Map

Chr2:68210445-68472268 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

261824 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 39.53 cM, cytoband C3
Mapping Data

5 experiments

Human Ortholog

STK39, serine/threonine kinase 39

Vertebrate Orthologs

10

Human Ortholog

STK39, serine/threonine kinase 39
Orthology source: HomoloGene, HGNC
Synonyms

DCHT, PASK, SPAK
Links

HGNC:17717

NCBI Gene ID: 27347

neXtProt AC: NX_Q9UEW8

UniProt: Q9UEW8
Chr Location

2q24.3; chr2:167954020-168247595 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22739
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: STK39
Gene Tree

Stk39

Diseases

1 with Stk39 mouse models

Human Disease

Mouse Models

Gitelman syndrome

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

26 phenotypes from 5 alleles in 5 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

4
Targeted

6
Genomic Mutations

1 involving Stk39
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.

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All GO Annotations

60
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

60
Tissues

15
cDNA Data

98
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk39

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Stk39 interacts with 269 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

51
RefSeq

11
UniProt

5
CCDS

CCDS16084.1
UniGene

198414

			Length	Strain/Species	Flank
genomic	OTTMUSG00000012975	VEGA Gene Model \| MGI Sequence Detail	261824	C57BL/6J	± kb
transcript	OTTMUST00000031247	VEGA \| MGI Sequence Detail	3536	Not Applicable
polypeptide	OTTMUSP00000013981	VEGA \| MGI Sequence Detail	556	Not Applicable

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SNPs within 2kb

2239 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000015756 STE20/SPS1-related proline-alanine-rich protein kinase

(term hierarchy)
PDB

5D9H, 5DBX
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

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All nucleic 99

cDNA 98

Primer pair 1

Microarray probesets 6

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MGI:2139330, MGI:2139399, MGI:3844884

Summaries

All 60

Developmental Gene Expression 2

Diseases 2

Gene Ontology 13

Phenotypes 23
Earliest

J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
Latest

J:237441 Cheng CJ, et al., STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb. Am J Physiol Renal Physiol. 2015 Mar 01;308(5):F437-43

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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