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Stk39 Gene Detail
Summary
  • Symbol
    Stk39
  • Name
    serine/threonine kinase 39
  • Synonyms
    DCHT, RF005, Rnl5, SPAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858416
    NCBI Gene: 53416
  • Gene Overview
    MyGene.info: STK39
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:68210445-68472268 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      261824 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.53 cM, cytoband C3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    STK39, serine/threonine kinase 39
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STK39, serine/threonine kinase 39
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCHT, PASK, SPAK
  • Links
    NCBI Gene ID: 27347
    neXtProt AC: NX_Q9UEW8
    UniProt: Q9UEW8

  • Chr Location
    2q24.3; chr2:167954020-168247595 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Stk39 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    64
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    60
  • Tissues
    15
  • cDNA Data
    98
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012975 VEGA Gene Model | MGI Sequence Detail 261824 C57BL/6J ±  kb
transcript OTTMUST00000031247 VEGA | MGI Sequence Detail 3536 Not Applicable  
polypeptide OTTMUSP00000013981 VEGA | MGI Sequence Detail 556 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2239 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 99
    cDNA 98
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2139330, MGI:2139399, MGI:3844884
References
more
  • Summaries
    All 64
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 14
    Phenotypes 23
  • Earliest
    J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
  • Latest
    J:237441 Cheng CJ, et al., STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb. Am J Physiol Renal Physiol. 2015 Mar 01;308(5):F437-43
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2018
MGI 6.11 		The Jackson Laboratory