About   Help   FAQ
Chst3
Gene Detail
Symbol

Name
ID
Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
MGI:1858224
Synonyms
C6ST, C6ST-1, GST-0
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.70 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:60181534-60194239 bp, - strand
From VEGA annotation of GRCm38

  12706 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CHST3
Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst3

Human
homologs
CHST3, carbohydrate (chondroitin 6) sulfotransferase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9469
neXtProt AC: NX_Q7LGC8

Human Synonyms: C6ST, C6ST1, HSD

Human Chr (Location): 10q22.1; chr10:71964362-72013564 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CHST3

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.
 
Human Diseases Modeled in Mice Using Chst3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Chst3 interacts with 340 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (234)    Tissues (179)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
In situ reporter (knock in) 96
RT-PCR 40
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN chst3a, chst3b    NEW 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035235 (Evidence)
Ensembl Gene Model ENSMUSG00000057337 (Evidence)
Entrez Gene 53374 (Evidence)
UniGene 12866
DFCI TC1598793, TC1602116, TC1644862, TC1704984
DoTS DT.101198690, DT.488506, DT.87048237
NIA Mouse Gene Index U031827
EC 2.8.2.-, 2.8.2.17
Consensus CDS Project CCDS23871.2
International Mouse Phenotyping Consortium Status Chst3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035235 VEGA Gene Model | MGI Sequence Detail 12706 C57BL/6J ±  kb
transcript OTTMUST00000089818 VEGA | MGI Sequence Detail 1672 Not Applicable 
polypeptide OTTMUSP00000049121 VEGA | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005476 carbohydrate sulfotransferase 3
References
(Earliest) J:47830 Uchimura K, et al., Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Glycobiology. 1998 May;8(5):489-96
(Latest) J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80
All references(38)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory