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Chst3
Gene Detail
 Symbol
Name
ID
Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
MGI:1858224
Synonyms C6ST, C6ST-1, GST-0
Feature Type protein coding gene
Genetic Map
Chromosome 10
29.70 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:60181534-60194239 bp, - strand
From VEGA annotation of GRCm38

  12706 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst3

Human
homologs
Human Homolog CHST3, carbohydrate (chondroitin 6) sulfotransferase 3
NCBI Gene ID 9469
neXtProt AC  NX_Q7LGC8
Human Synonyms  C6ST, C6ST1, HSD
Human Chr (Location)  10q22.1; chr10:71964362-72013564 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CHST3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.
 
Human Diseases Modeled Using Mouse Chst3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Chst3 interacts with 341 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process carbohydrate metabolic process, chondroitin sulfate biosynthetic process, ...
Component Golgi apparatus, Golgi membrane, ...
Function chondroitin 6-sulfotransferase activity, proteoglycan sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (234)    Tissues (179)    Images (65)
Theiler Stages: 21, 22, 28
Assay TypeResults
RNA in situ 98
In situ reporter (knock in) 96
RT-PCR 40
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035235 (Evidence)
Ensembl Gene ModelENSMUSG00000057337 (Evidence)
Entrez Gene53374 (Evidence)
UniGene12866
DFCITC1598793, TC1602116, TC1644862, TC1704984
DoTSDT.101198690, DT.488506, DT.87048237
NIA Mouse Gene IndexU031827
EC2.8.2.17
Consensus CDS ProjectCCDS23871.2
International Mouse Knockout Project StatusChst3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035235 VEGA Gene Model | MGI Sequence Detail 12706 C57BL/6J ±  kb
transcript OTTMUST00000089819 VEGA | MGI Sequence Detail 5985 Not Applicable 
polypeptide OTTMUSP00000049122 VEGA | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005476 carbohydrate sulfotransferase 3
References (Earliest) J:47830 Uchimura K, et al., Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Glycobiology. 1998 May;8(5):489-96
(Latest) J:203546 Patnode ML, et al., Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013 Sep 13;288(37):26533-45
All references(36)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory