Chst3
Gene Detail

Symbol Name ID

Chst3 carbohydrate (chondroitin 6/keratan) sulfotransferase 3 MGI:1858224

Synonyms

C6ST, C6ST-1, GST-0

Feature Type

protein coding gene

Genetic Map

Chromosome 10

29.70 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:60181534-60194239 bp, - strand From VEGA annotation of GRCm38   12706 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Chst3 ± 2 cM)

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst3

Human ortholog

CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 NCBI Gene ID 9469
Human Synonyms: C6ST, C6ST1, HSD
Human Chr10:73724120-73773322 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CHST3 (2)

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(6)
 

Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.

 
Human Diseases Modeled Using Mouse Chst3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	carbohydrate metabolic process, chondroitin sulfate biosynthetic process, ...
Component	Golgi apparatus, Golgi membrane, ...
Function	chondroitin 6-sulfotransferase activity, proteoglycan sulfotransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (234)    Tissues (179)    Images (65)
Theiler Stages: 21, 22, 28

Assay Type	Results
RNA in situ	98
In situ reporter (knock in)	96
RT-PCR	40

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035235 (Evidence)
Ensembl Gene Model	ENSMUSG00000057337 (Evidence)
Entrez Gene	53374 (Evidence)
UniGene	12866
DFCI	TC1598793, TC1602116, TC1644862, TC1704984
DoTS	DT.101198690, DT.488506, DT.87048237
NIA Mouse Gene Index	U031827
EC	2.8.2.17
Consensus CDS Project	CCDS23871.2
International Mouse Knockout Project Status	Chst3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035235	VEGA Gene Model | MGI Sequence Detail	12706	C57BL/6J
transcript	OTTMUST00000089819	VEGA | MGI Sequence Detail	5985	Not Applicable
polypeptide	OTTMUSP00000049122	VEGA | MGI Sequence Detail	472	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016469	Carbohydrate sulfotransferase
InterPro	IPR000863	Sulfotransferase domain
Protein Ontology	PR:000005476	carbohydrate sulfotransferase 3

References

(Earliest) J:47830 Uchimura K, et al., Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Glycobiology. 1998 May;8(5):489-96
(Latest) J:182313 Miyata S, et al., Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat Neurosci. 2012;15(3):414-22, S1-2
All references(35)