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Chst3 Gene Detail
Summary
  • Symbol
    Chst3
  • Name
    carbohydrate sulfotransferase 3
  • Synonyms
    C6ST, C6ST-1, GST-0
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858224
    NCBI Gene: 53374
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:60181532-60219260 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 29.70 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    350 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858224
protein coding gene Chr10:60181527-60221094 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017266
protein coding gene Chr10:59401600-59440425 (-)
A/J MGP_AJ_G0017244
protein coding gene Chr10:57654291-57692082 (-)
AKR/J MGP_AKRJ_G0017204
protein coding gene Chr10:59160049-59198191 (-)
BALB/cJ MGP_BALBcJ_G0017204
protein coding gene Chr10:57740565-57779099 (-)
C3H/HeJ MGP_C3HHeJ_G0017027
protein coding gene Chr10:59084176-59122157 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017662
protein coding gene Chr10:61526501-61566962 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015353
protein coding gene Chr10:54657249-54694752 (-)
CAST/EiJ MGP_CASTEiJ_G0016598
protein coding gene Chr10:59024582-59061511 (-)
CBA/J MGP_CBAJ_G0016999
protein coding gene Chr10:63750953-63798861 (-)
DBA/2J MGP_DBA2J_G0017104
protein coding gene Chr10:56960286-56998208 (-)
FVB/NJ MGP_FVBNJ_G0017098
protein coding gene Chr10:56195429-56233168 (-)
LP/J MGP_LPJ_G0017179
protein coding gene Chr10:59778772-59819898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017126
protein coding gene Chr10:66227865-66270395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017700
protein coding gene Chr10:58964448-59005913 (-)
PWK/PhJ MGP_PWKPhJ_G0016381
protein coding gene Chr10:56768636-56806956 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016164
protein coding gene Chr10:58294178-58339845 (-)
WSB/EiJ MGP_WSBEiJ_G0016662
protein coding gene Chr10:58876117-58922166 (-)



Homology
more
  • Human Ortholog
    CHST3, carbohydrate sulfotransferase 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHST3, carbohydrate sulfotransferase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C6ST, C6ST1, HSD
  • Links
    NCBI Gene ID: 9469
    neXtProt AC: NX_Q7LGC8
    UniProt: Q7LGC8

  • Chr Location
    10q22.1; chr10:71964362-72013564 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Chst3 mouse models; 1 with human CHST3 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057337 Ensembl Gene Model | MGI Sequence Detail 37729 C57BL/6J ±  kb
    transcript ENSMUST00000135158 Ensembl | MGI Sequence Detail 6108 Not Applicable  
    polypeptide ENSMUSP00000126281 Ensembl | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:229564 Yutsudo N, et al., Involvement of chondroitin 6-sulfation in temporal lobe epilepsy. Exp Neurol. 2015 Dec;274(Pt B):126-33

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory