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Socs1 Gene Detail
Summary
  • Symbol
    Socs1
  • Name
    suppressor of cytokine signaling 1
  • Synonyms
    Cish1, Cish7, JAB, JAK2-binding protein, JAK-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354910
    NCBI Gene: 12703
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10783808-10785536 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 5.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354910
protein coding gene Chr16:10782240-10785536 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022511
protein coding gene Chr16:7611169-7612897 (-)
A/J MGP_AJ_G0022473
protein coding gene Chr16:7193607-7195335 (-)
AKR/J MGP_AKRJ_G0022449
protein coding gene Chr16:7513766-7515494 (-)
BALB/cJ MGP_BALBcJ_G0022477
protein coding gene Chr16:7324283-7326011 (-)
C3H/HeJ MGP_C3HHeJ_G0022244
protein coding gene Chr16:7598993-7600722 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022926
protein coding gene Chr16:7758614-7760342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020447
protein coding gene Chr16:7339355-7341081 (-)
CAST/EiJ MGP_CASTEiJ_G0021771
protein coding gene Chr16:7618077-7619805 (-)
CBA/J MGP_CBAJ_G0022213
protein coding gene Chr16:8110373-8112102 (-)
DBA/2J MGP_DBA2J_G0022344
protein coding gene Chr16:7196825-7198554 (-)
FVB/NJ MGP_FVBNJ_G0022320
protein coding gene Chr16:7178067-7179795 (-)
LP/J MGP_LPJ_G0022412
protein coding gene Chr16:7563483-7565211 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022342
protein coding gene Chr16:7818619-7820347 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022939
protein coding gene Chr16:7469283-7471011 (-)
PWK/PhJ MGP_PWKPhJ_G0021511
protein coding gene Chr16:7405689-7407417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021341
protein coding gene Chr16:7527453-7529178 (-)
WSB/EiJ MGP_WSBEiJ_G0021819
protein coding gene Chr16:7547880-7549608 (-)



Homology
more
  • Human Ortholog
    SOCS1, suppressor of cytokine signaling 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOCS1, suppressor of cytokine signaling 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIS1, CISH1, JAB, SOCS-1, SSI1, SSI-1, TIP3, TIP-3
  • Links
    NCBI Gene ID: 8651
    neXtProt AC: NX_O15524
    UniProt: O15524

  • Chr Location
    16p13.13; chr16:11254417-11256182 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 9 alleles in 13 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retarded growth, hyperresponsiveness to endogenous interferon gamma, hepatitis with fatty degeneration, lymphopenia due to excess apoptosis, monocytic organ infiltration, and lethality by 3 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12703 NCBI Gene Model | MGI Sequence Detail 1729 C57BL/6J ±  kb
    transcript NM_001271603 RefSeq | MGI Sequence Detail 1340 C57BL/6  
    polypeptide O35716 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 55

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1276585
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 6
      Gene Ontology 18
      Phenotypes 82
    • Earliest
      J:30554 Schluter G, et al., Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. Mol Reprod Dev. 1996 Jan;43(1):1-6
    • Latest
      J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory