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Socs1 Gene Detail
Summary
  • Symbol
    Socs1
  • Name
    suppressor of cytokine signaling 1
  • Synonyms
    Cish1, Cish7, JAB, JAK2-binding protein, JAK-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354910
    NCBI Gene: 12703
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:10783808-10785536 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1729 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 5.81 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SOCS1, suppressor of cytokine signaling 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOCS1, suppressor of cytokine signaling 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIS1, CISH1, JAB, SOCS-1, SSI1, SSI-1, TIP3, TIP-3
  • Links
    NCBI Gene ID: 8651
    neXtProt AC: NX_O15524
    UniProt: O15524

  • Chr Location
    16p13.13; chr16:11254417-11256182 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 9 alleles in 13 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retarded growth, hyperresponsiveness to endogenous interferon gamma, hepatitis with fatty degeneration, lymphopenia due to excess apoptosis, monocytic organ infiltration, and lethality by 3 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12703 NCBI Gene Model | MGI Sequence Detail 1729 C57BL/6J ±  kb
    transcript NM_001271603 RefSeq | MGI Sequence Detail 1340 C57BL/6  
    polypeptide O35716 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      39 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 1
      cDNA 54

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1276585
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 5
      Gene Ontology 17
      Phenotypes 81
    • Earliest
      J:30554 Schluter G, et al., Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. Mol Reprod Dev. 1996 Jan;43(1):1-6
    • Latest
      J:253405 Alice AF, et al., Amplifying IFN-gamma Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity. J Immunol. 2018 Jan 1;200(1):177-185

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory