About   Help   FAQ
Akr1c12 Gene Detail
Summary
  • Symbol
    Akr1c12
  • Name
    aldo-keto reductase family 1, member C12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351661
    NCBI Gene: 622402
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4268172-4279399 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 2.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351661
protein coding gene Chr13:4268172-4279433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020206
protein coding gene Chr13:757635-769380 (-)
A/J MGP_AJ_G0020162
protein coding gene Chr13:849501-868382 (-)
AKR/J MGP_AKRJ_G0020137
protein coding gene Chr13:867341-878610 (-)
BALB/cJ MGP_BALBcJ_G0020145
protein coding gene Chr13:850585-866493 (-)
C3H/HeJ MGP_C3HHeJ_G0019949
protein coding gene Chr13:944920-956409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020592
protein coding gene Chr13:829028-848289 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019489
protein coding gene Chr13:777250-785227 (-)
CBA/J MGP_CBAJ_G0019916
protein coding gene Chr13:841816-854546 (-)
DBA/2J MGP_DBA2J_G0020033
protein coding gene Chr13:765536-776571 (-)
FVB/NJ MGP_FVBNJ_G0020018
protein coding gene Chr13:730245-742750 (-)
LP/J MGP_LPJ_G0020107
protein coding gene Chr13:845963-856476 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020054
protein coding gene Chr13:903479-924447 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020620
protein coding gene Chr13:827362-839569 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0019057
protein coding gene Chr13:867648-878441 (-)
WSB/EiJ MGP_WSBEiJ_G0019547
protein coding gene Chr13:775474-787537 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 622402 NCBI Gene Model | MGI Sequence Detail 11228 C57BL/6J ±  kb
transcript NM_013777 RefSeq | MGI Sequence Detail 1231 C57BL/6  
polypeptide NP_038805 RefSeq | MGI Sequence Detail 323 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR020471 Aldo/keto reductase
    IPR018170 Aldo/keto reductase, conserved site
    IPR023210 NADP-dependent oxidoreductase domain
    IPR036812 NADP-dependent oxidoreductase domain superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145199
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:58090 Ikeda S, et al., Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach. FEBS Lett. 1999 Oct 15;459(3):433-7
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/16/2019
MGI 6.14
The Jackson Laboratory