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Pdk4
Gene Detail
Symbol

Name
ID
Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
MGI:1351481
Feature Type
protein coding gene
Genetic Map
Chromosome 6
2.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:5483351-5496309 bp, - strand
From VEGA annotation of GRCm38

  12959 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PDK4
Protein SuperFamily: branched-chain alpha-keto acid dehydrogenase kinase
Gene Tree: Pdk4

Human
homologs
PDK4, pyruvate dehydrogenase kinase, isozyme 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5166
neXtProt AC: NX_Q16654

Human Chr (Location): 7q21.3; chr7:95583497-95596613 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit altered glucose homoeostasis during starvation.
 
Interactions
Pdk4 interacts with 302 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component mitochondrial inner membrane, mitochondrion
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdk4    NEW 
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026853 (Evidence)
Ensembl Gene Model ENSMUSG00000019577 (Evidence)
Entrez Gene 27273 (Evidence)
UniGene 235547
DFCI TC1580048
DoTS DT.87068828
NIA Mouse Gene Index U027024
EC 2.7.11.2
Consensus CDS Project CCDS19902.1
International Mouse Phenotyping Consortium Status Pdk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026853 VEGA Gene Model | MGI Sequence Detail 12959 C57BL/6J ±  kb
transcript OTTMUST00000066404 VEGA | MGI Sequence Detail 3484 Not Applicable 
polypeptide OTTMUSP00000033277 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
InterPro IPR005467 Histidine kinase domain
InterPro IPR003594 Histidine kinase-like ATPase, C-terminal domain
Protein Ontology PR:000012507 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
References
(Earliest) J:58666 Bowker-Kinley M, et al., Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily. Biochem J. 1999 Nov 15;344 Pt 1:47-53
(Latest) J:216745 Rahimi Y, et al., Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16508-13
All references(55)
Other
accession IDs
MGI:2141608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory