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Pdk4
Gene Detail
 Symbol
Name
ID
Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
MGI:1351481
Feature Type protein coding gene
Genetic Map
Chromosome 6
2.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:5483351-5496309 bp, - strand
From VEGA annotation of GRCm38

  12959 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: branched-chain alpha-keto acid dehydrogenase kinase
Gene Tree: Pdk4

Human
homologs
Human Homolog PDK4, pyruvate dehydrogenase kinase, isozyme 4
NCBI Gene ID 5166
neXtProt AC  NX_Q16654
Human Chr (Location)  7q21.3; chr7:95583497-95596613 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit altered glucose homoeostasis during starvation.
 
Interactions
Pdk4 interacts with 302 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component mitochondrial inner membrane, mitochondrion
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026853 (Evidence)
Ensembl Gene ModelENSMUSG00000019577 (Evidence)
Entrez Gene27273 (Evidence)
UniGene235547
DFCITC1580048
DoTSDT.87068828
NIA Mouse Gene IndexU027024
EC2.7.11.2
Consensus CDS ProjectCCDS19902.1
International Mouse Knockout Project StatusPdk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026853 VEGA Gene Model | MGI Sequence Detail 12959 C57BL/6J ±  kb
transcript OTTMUST00000066404 VEGA | MGI Sequence Detail 3484 Not Applicable 
polypeptide OTTMUSP00000033277 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR005467 Signal transduction histidine kinase, core
Protein Ontology PR:000012507 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
References (Earliest) J:58666 Bowker-Kinley M, et al., Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily. Biochem J. 1999 Nov 15;344 Pt 1:47-53
(Latest) J:208284 Herbst EA, et al., Pyruvate dehydrogenase kinase-4 contributes to the recirculation of gluconeogenic precursors during postexercise glycogen recovery. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15;306(2):R102-7
All references(53)
Other
accession IDs
MGI:2141608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory