Pdk4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
MGI:1351481

20 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdk4^tm1Rhar/Pdk4^tm1Rhar B6.129-Pdk4^tm1Rhar	abnormal blood homeostasis	J:115895
	abnormal circulating amino acid level	J:115895
	abnormal glucose homeostasis	J:115895
	abnormal glycerol level	J:115895
	decreased circulating alanine level	J:115895
	decreased circulating glucose level	J:115895
	decreased circulating lactate level	J:115895
	decreased liver glycogen level	J:115895
	improved glucose tolerance	J:115895
	increased circulating free fatty acids level	J:115895
	increased circulating insulin level	J:115895
	increased circulating ketone body level	J:115895
	ketosis	J:115895
Pdk4^tm1Tok/Pdk4^tm1Tok B6.129P2-Pdk4^tm1Tok	abnormal bone volume	J:179789
	abnormal osteoclast cell number	J:179789
	abnormal osteoclast differentiation	J:179789
	abnormal osteoclast morphology	J:179789
	abnormal trabecular bone morphology	J:179789
	abnormal trabecular bone thickness	J:179789
	abnormal trabecular bone volume	J:179789

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23