Sequence Detail

ID/Version

O70571 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; EC=2.7.11.2;AltName: Full=Pyruvate dehydrogenase kinase isoform 4;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 412 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	38	107	3	10

Sequence references in MGI

J:115895 Jeoung NH, et al., Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. Biochem J. 2006 Aug 1;397(3):417-25
J:132373 Zhao G, et al., Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H936-43
J:137665 Jeoung NH, et al., Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E46-54
J:156363 Hwang B, et al., Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet. Biochem J. 2009 Oct 15;423(2):243-52
J:166353 Degenhardt T, et al., Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J Mol Biol. 2007 Sep 14;372(2):341-55
J:170902 Chambers KT, et al., Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem. 2011 Apr 1;286(13):11155-62
J:179789 Wang Y, et al., Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. Bone. 2012 Jan;50(1):409-19
J:185475 Jeoung NH, et al., Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice. Biochem J. 2012 May 1;443(3):829-39
J:198897 Ussher JR, et al., Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. Cardiovasc Res. 2012 May 1;94(2):359-69
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89