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Ror2 Gene Detail
Summary
  • Symbol
    Ror2
  • Name
    receptor tyrosine kinase-like orphan receptor 2
  • Synonyms
    Ntrkr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347521
    NCBI Gene: 26564
  • Gene Overview
    MyGene.info: ROR2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:53109312-53286124 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      176813 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 27.68 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDB, BDB1, NTRKR2
  • Links
    NCBI Gene ID: 4920
    neXtProt AC: NX_Q01974
    UniProt: Q01974

  • Chr Location
    9q22.31; chr9:91722596-91950206 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ror2 mouse models; 2 with human ROR2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    129 phenotypes from 6 alleles in 5 genetic backgrounds
    23 phenotypes from multigenic genotypes
    9 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031749 VEGA Gene Model | MGI Sequence Detail 176813 C57BL/6J ±  kb
    transcript OTTMUST00000078648 VEGA | MGI Sequence Detail 3985 Not Applicable  
    polypeptide OTTMUSP00000041852 VEGA | MGI Sequence Detail 944 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1374 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 39
      Primer pair 4
      Other 7

      Microarray probesets 6
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 38
      Diseases 2
      Gene Ontology 14
      Phenotypes 42
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:257510 Zhu XJ, et al., Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly. FEBS Lett. 2018 Feb;592(3):356-368

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory