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Ror2
Gene Detail
Symbol

Name
ID
Ror2
receptor tyrosine kinase-like orphan receptor 2
MGI:1347521
Synonyms
Ntrkr2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
27.68 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:53109312-53286124 bp, - strand
From VEGA annotation of GRCm38

  176813 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase transmembrane receptor ROR
Gene Tree: Ror2

Human
homologs
Human Homolog ROR2, receptor tyrosine kinase-like orphan receptor 2
NCBI Gene ID 4920
neXtProt AC  NX_Q01974
Human Synonyms  BDB, BDB1, NTRKR2
Human Chr (Location)  9q22; chr9:91722596-91950162 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ROR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Chemically induced (ENU)(1) Gene trapped(71) Targeted(8) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.
 
Human Diseases Modeled Using Mouse Ror2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(9)
Interactions
Ror2 interacts with 131 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cartilage condensation, cell differentiation, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function ATP binding, frizzled binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (298)    Tissues (257)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 256
In situ reporter (knock in) 17
Northern blot 6
RT-PCR 13
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(37) Primer pair(4) Other(7)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000031749 (Evidence)
Ensembl Gene ModelENSMUSG00000021464 (Evidence)
Entrez Gene26564 (Evidence)
UniGene342774
EC2.7.10.1
Consensus CDS ProjectCCDS26520.1
International Mouse Knockout Project StatusRor2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031749 VEGA Gene Model | MGI Sequence Detail 176813 C57BL/6J ±  kb
transcript OTTMUST00000078648 VEGA | MGI Sequence Detail 3985 Not Applicable 
polypeptide OTTMUSP00000041852 VEGA | MGI Sequence Detail 944 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(1394 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016247 Tyrosine-protein kinase, receptor ROR
Protein Ontology PR:000014162 tyrosine-protein kinase transmembrane receptor ROR2
References
(Earliest) J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
(Latest) J:213602 Arora R, et al., Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug;243(8):1037-45
All references(80)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory