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Ror2 Gene Detail
Summary
  • Symbol
    Ror2
  • Name
    receptor tyrosine kinase-like orphan receptor 2
  • Synonyms
    Ntrkr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347521
    NCBI Gene: 26564
  • Gene Overview
    MyGene.info: ROR2
Location & Maps
more
  • Sequence Map
    Chr13:53109312-53286124 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      176813 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 27.68 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDB, BDB1, NTRKR2
  • Links
    NCBI Gene ID: 4920
    neXtProt AC: NX_Q01974

  • Chr Location
    9q22; chr9:91722596-91950162 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Ror2 mouse models; 2 with human ROR2 associations

Human Disease Mouse Models
       Brachydactyly, Type B1; BDB1   OMIM: 113000 View 1 "NOT" model
Robinow Syndrome, Autosomal Recessive; RRS   OMIM: 268310 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    124 phenotypes from 6 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    9 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    82
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    71
  • Targeted
    8
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Ror2
  • Incidental Mutations
Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031749 VEGA Gene Model | MGI Sequence Detail 176813 C57BL/6J ±  kb
transcript OTTMUST00000078648 VEGA | MGI Sequence Detail 3985 Not Applicable  
polypeptide OTTMUSP00000041852 VEGA | MGI Sequence Detail 944 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1374 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 37
    Primer pair 4
    Other 7

    Microarray probesets 6
References
more
  • Summaries
    All 86
    Developmental Gene Expression 35
    Diseases 2
    Gene Ontology 12
    Phenotypes 40
  • Earliest
    J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
  • Latest
    J:229484 Conte D, et al., The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016 Feb 15;25(4):740-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory