About   Help   FAQ
Ror2 Gene Detail
Summary
  • Symbol
    Ror2
  • Name
    receptor tyrosine kinase-like orphan receptor 2
  • Synonyms
    Ntrkr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347521
    NCBI Gene: 26564
  • Gene Overview
    MyGene.info: ROR2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:53109317-53286109 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 27.68 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1374 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347521
protein coding gene Chr13:53109312-53286124 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020560
protein coding gene Chr13:52422827-52612873 (-)
A/J MGP_AJ_G0020514
protein coding gene Chr13:50535252-50712690 (-)
AKR/J MGP_AKRJ_G0020492
protein coding gene Chr13:51972713-52154942 (-)
BALB/cJ MGP_BALBcJ_G0020510
protein coding gene Chr13:50748605-50926883 (-)
C3H/HeJ MGP_C3HHeJ_G0020309
protein coding gene Chr13:51819656-52004561 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020944
protein coding gene Chr13:54040729-54227387 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018526
protein coding gene Chr13:48316291-48492723 (-)
CAST/EiJ MGP_CASTEiJ_G0019823
protein coding gene Chr13:51828614-52018502 (-)
CBA/J MGP_CBAJ_G0020269
protein coding gene Chr13:56069128-56278049 (-)
DBA/2J MGP_DBA2J_G0020392
protein coding gene Chr13:50102097-50279950 (-)
FVB/NJ MGP_FVBNJ_G0020371
protein coding gene Chr13:49546410-49724161 (-)
LP/J MGP_LPJ_G0020468
protein coding gene Chr13:52693266-52881432 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020400
protein coding gene Chr13:55641461-55831384 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020987
protein coding gene Chr13:51582061-51772618 (-)
PWK/PhJ MGP_PWKPhJ_G0019579
protein coding gene Chr13:50049300-50233407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019406
protein coding gene Chr13:50480514-50673304 (-)
WSB/EiJ MGP_WSBEiJ_G0019885
protein coding gene Chr13:51895657-52088988 (-)



Homology
more
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDB, BDB1, NTRKR2
  • Links
    NCBI Gene ID: 4920
    neXtProt AC: NX_Q01974
    UniProt: Q01974

  • Chr Location
    9q22.31; chr9:91722596-91950206 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ror2 mouse models; 2 with human ROR2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    129 phenotypes from 6 alleles in 5 genetic backgrounds
    23 phenotypes from multigenic genotypes
    9 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26564 NCBI Gene Model | MGI Sequence Detail 176793 C57BL/6J ±  kb
    transcript NM_013846 RefSeq | MGI Sequence Detail 3987 C57BL/6  
    polypeptide Q9Z138 UniProt | EBI | MGI Sequence Detail 944 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 39
      Primer pair 4
      Other 7

      Microarray probesets 6
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 41
      Diseases 2
      Gene Ontology 16
      Phenotypes 43
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:266389 Yin W, et al., The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018 Jul 19;9(1):2815

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory