About   Help   FAQ
Gene Detail
receptor tyrosine kinase-like orphan receptor 2
Synonyms Ntrkr2
Feature Type protein coding gene
Genetic Map
Chromosome 13
27.68 cM, cytoband B3
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr13:53109312-53286124 bp, - strand
From VEGA annotation of GRCm38

  176813 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:55831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase transmembrane receptor ROR
Gene Tree: Ror2

Human Homolog ROR2, receptor tyrosine kinase-like orphan receptor 2
NCBI Gene ID 4920
neXtProt AC  NX_Q01974
Human Synonyms  BDB, BDB1, NTRKR2
Human Chr (Location)  9q22; chr9:91722596-91950162 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ROR2
alleles, and
All mutations/alleles(81) : Chemically induced (ENU)(1) Gene trapped(71) Targeted(8) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.
Human Diseases Modeled Using Mouse Ror2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(9)
Ror2 interacts with 131 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
All GO classifications: (41 annotations)
Process cartilage condensation, cell differentiation, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function ATP binding, frizzled binding, ...
External Resources: FuncBase
Literature Summary: (30 records)
Data Summary: Results (298)    Tissues (257)    Images (45)
Theiler Stages: 1, 2, 3, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 256
In situ reporter (knock in) 17
Northern blot 6
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(48) cDNA(37) Primer pair(4) Other(7)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000031749 (Evidence)
Ensembl Gene ModelENSMUSG00000021464 (Evidence)
Entrez Gene26564 (Evidence)
Consensus CDS ProjectCCDS26520.1
International Mouse Knockout Project StatusRor2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031749 VEGA Gene Model | MGI Sequence Detail 176813 C57BL/6J ±  kb
transcript OTTMUST00000078648 VEGA | MGI Sequence Detail 3985 Not Applicable 
polypeptide OTTMUSP00000041852 VEGA | MGI Sequence Detail 944 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(1394 from dbSNP Build 137)
InterPro IPR020067 Frizzled domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016247 Tyrosine-protein kinase, receptor ROR
Protein Ontology PR:000014162 tyrosine-protein kinase transmembrane receptor ROR2
References (Earliest) J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
(Latest) J:210471 Okamoto M, et al., Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis. Sci Rep. 2014;4:4493
All references(78)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory