Ror2
Gene Detail

Symbol Name ID

Ror2 receptor tyrosine kinase-like orphan receptor 2 MGI:1347521

Synonyms

Ntrkr2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

27.68 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:53109312-53286124 bp, - strand From VEGA annotation of GRCm38   176813 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase transmembrane receptor ROR
Gene Tree: Ror2

Human homologs

Human Homolog		ROR2, receptor tyrosine kinase-like orphan receptor 2
NCBI Gene ID		4920
neXtProt AC		NX_Q01974
Human Synonyms		BDB, BDB1, NTRKR2
Human Chr (Location)		9q22; chr9:94484878-94712444 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ROR2

Alleles and phenotypes

All alleles(81) : Targeted(8) Gene trapped(71) Chemically induced(1) Transposon induced(1)
 

Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.

 
Human Diseases Modeled Using Mouse Ror2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(9)

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cartilage condensation, cell differentiation, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	ATP binding, frizzled binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (129)    Tissues (97)    Images (21)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	83
In situ reporter (knock in)	17
Northern blot	6
RT-PCR	17

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(15) Primer pair(4) Other(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000031749 (Evidence)
Ensembl Gene Model	ENSMUSG00000021464 (Evidence)
Entrez Gene	26564 (Evidence)
EC	2.7.10.1
Consensus CDS Project	CCDS26520.1
International Mouse Knockout Project Status	Ror2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031749	VEGA Gene Model | MGI Sequence Detail	176813	C57BL/6J
transcript	OTTMUST00000078648	VEGA | MGI Sequence Detail	3985	Not Applicable
polypeptide	OTTMUSP00000041852	VEGA | MGI Sequence Detail	944	Not Applicable

All sequences(33) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(982 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020067	Frizzled domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016247	Tyrosine-protein kinase, receptor ROR
Protein Ontology	PR:000014162	tyrosine-protein kinase transmembrane receptor ROR2

References

(Earliest) J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
(Latest) J:187747 Miyoshi H, et al., Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13
All references(73)