About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3793282
Allelic
Composition
Ror2tm1Anec/Ror2tm1Anec
Genetic
Background
B6.129S1-Ror2tm1Anec
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ror2tm1Anec mutation (0 available); any Ror2 mutation (107 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system

cellular
• reduced number but normal motility and fertilization capability

skeleton
• absence of P2
• reduced longitudinal axis
• increased intra-orbital width
• resulting from reduced length of the anterior region from the infradentale to the menton landmarks
• present at E18.5 in association with misshapen thoracic vertebrae
• deformities and titling are seen at E14.5
• hypoplastic and irregularly stacked at E14.5
• smaller and titled at E18.5
• presence of hemivertebrae results in tail kinks
• seen in about 5% of mice
• misshapen in about 20% of mice at E18.5
• at 3 weeks of age a 52% reduction in trabecular bone volume is seen in the femur
• at 3 weeks of age a a 57% decrease in the number of trabeculae is seen in the femur
• hypoplastic with reduction in the size of all anlagens at E14.5
• reduced number of cells in chondrogenic condensations at E13; however cell density appears unaffected
• onset of developmental hallmarks (hypertrophy, vascularization) is delayed
• mineral apposition rate is lower but mineralizing surface per bone surface is increased resulting in an increased calculated bone formation rate
• delayed ossification of the metacarpals, metatarsals, and phalanges at E18.5

limbs/digits/tail
• stylopod and zeugopod bones are 12-19% shorter than in controls at weaning but this difference decreases with age
• 5% display bifid digit I on the right hind paw
• absence of P2
• on fore and hind paws
• reduced size of cartilage condensations at E14.5
• impaired segmentation of the digital rays at E14.5 but otherwise patterning is normal
• presence of hemivertebrae results in tail kinks
• seen in about 5% of mice
• 25% have one or more tail kinks

growth/size/body
• increased relative to body weight
• detectable before weaning
• decrease in length but not in width

adipose tissue
• decreased fat mass

homeostasis/metabolism
N
• despite changes in body mass, no significant differences in metabolic parameters or glucose or insulin tolerances are detected

reproductive system
• reduced number but normal motility and fertilization capability
• in early puberty the density of tubules is decreased and only a single basal cell layer is present within the tubules
• these abnormalities are partially resolved in adults
• in early puberty
• at 2 months of age
• in trial matings to CD-1 females the pregnancy rate is 4% compared to 15% for heterozygous controls
• however, female fertility is normal

vision/eye
• increased intra-orbital width
• often associated with excessive tearing

craniofacial
• increased intra-orbital width
• resulting from reduced length of the anterior region from the infradentale to the menton landmarks

endocrine/exocrine glands
• in early puberty the density of tubules is decreased and only a single basal cell layer is present within the tubules
• these abnormalities are partially resolved in adults
• in early puberty
• at 2 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive Robinow syndrome DOID:0060764 OMIM:268310
J:134490


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
03/14/2023
MGI 6.22
The Jackson Laboratory