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Tlr2 Gene Detail
Summary
  • Symbol
    Tlr2
  • Name
    toll-like receptor 2
  • Synonyms
    Ly105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346060
    NCBI Gene: 24088
  • Gene Overview
    MyGene.info: TLR2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:83836272-83841767 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346060
protein coding gene Chr3:83836272-83841824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027337
protein coding gene Chr3:83704326-83709822 (-)
A/J MGP_AJ_G0027301
protein coding gene Chr3:80947540-80953035 (-)
AKR/J MGP_AKRJ_G0027267
protein coding gene Chr3:82852325-82857820 (-)
BALB/cJ MGP_BALBcJ_G0027310
protein coding gene Chr3:81017435-81022930 (-)
C3H/HeJ MGP_C3HHeJ_G0027054
protein coding gene Chr3:83148214-83153709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027756
protein coding gene Chr3:86842477-86847972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025109
protein coding gene Chr3:76605003-76610527 (-)
CAST/EiJ MGP_CASTEiJ_G0026501
protein coding gene Chr3:83335371-83340852 (-)
CBA/J MGP_CBAJ_G0027029
protein coding gene Chr3:89768282-89773777 (-)
DBA/2J MGP_DBA2J_G0027165
protein coding gene Chr3:80468091-80473586 (-)
FVB/NJ MGP_FVBNJ_G0027133
protein coding gene Chr3:78753061-78758556 (-)
LP/J MGP_LPJ_G0027273
protein coding gene Chr3:84673398-84678894 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027152
protein coding gene Chr3:96143464-96148959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027814
protein coding gene Chr3:82646608-82652104 (-)
PWK/PhJ MGP_PWKPhJ_G0026235
protein coding gene Chr3:80230609-80236220 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026051
protein coding gene Chr3:81827332-81832839 (-)
WSB/EiJ MGP_WSBEiJ_G0026579
protein coding gene Chr3:83001018-83006513 (-)



Homology
more
  • Human Ortholog
    TLR2, toll like receptor 2
  • Vertebrate Orthologs
    13
  • Human Ortholog
    TLR2, toll like receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD282, TIL4
  • Links
    NCBI Gene ID: 7097
    neXtProt AC: NX_O60603
    UniProt: O60603

  • Chr Location
    4q31.3; chr4:153684080-153710643 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TLR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    120 phenotypes from 4 alleles in 12 genetic backgrounds
    18 phenotypes from multigenic genotypes
    801 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections. Mice homozygous for a knock-out allele also exhibit disruption in circadian active and inactive state consolidation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027995 Ensembl Gene Model | MGI Sequence Detail 5496 C57BL/6J ±  kb
    transcript ENSMUST00000029623 Ensembl | MGI Sequence Detail 3014 Not Applicable  
    polypeptide ENSMUSP00000029623 Ensembl | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 1115
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 27
      Phenotypes 801
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:266796 Wanderley CW, et al., Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. Cancer Res. 2018 Oct 15;78(20):5891-5900

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory