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Tlr2 Gene Detail
Summary
  • Symbol
    Tlr2
  • Name
    toll-like receptor 2
  • Synonyms
    Ly105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346060
    NCBI Gene: 24088
  • Gene Overview
    MyGene.info: TLR2
Location & Maps
more
  • Sequence Map
    Chr3:83836272-83841767 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5496 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TLR2, toll like receptor 2
  • Vertebrate Orthologs
    13
  • Human Ortholog
    TLR2, toll like receptor 2
    Orthology source: HomoloGene
  • Synonyms
    CD282, TIL4
  • Links
    NCBI Gene ID: 7097
    neXtProt AC: NX_O60603

  • Chr Location
    4q32; chr4:153684256-153706091 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tlr2 mouse models; 2 with human TLR2 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
       Leprosy, Susceptibility to, 3; LPRS3   OMIM: 246300
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    114 phenotypes from 4 alleles in 12 genetic backgrounds
    18 phenotypes from multigenic genotypes
    718 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Tlr2
  • Incidental Mutations
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051567 VEGA Gene Model | MGI Sequence Detail 5496 C57BL/6J ±  kb
transcript OTTMUST00000130194 VEGA | MGI Sequence Detail 3014 Not Applicable  
polypeptide OTTMUSP00000069825 VEGA | MGI Sequence Detail 784 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 22
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 930
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 24
    Phenotypes 718
  • Earliest
    J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
  • Latest
    J:230432 Wang Y, et al., TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory