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Tlr2
Gene Detail
 Symbol
Name
ID
Tlr2
toll-like receptor 2
MGI:1346060
Synonyms Ly105
Feature Type protein coding gene
Genetic Map
Chromosome 3
37.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:83836272-83841608 bp, - strand
From NCBI annotation of GRCm38

  5337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr2

Human
homologs
Human Homolog TLR2, toll-like receptor 2
NCBI Gene ID 7097
neXtProt AC  NX_O60603
Human Synonyms  CD282, TIL4
Human Chr (Location)  4q32; chr4:153684252-153706091 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TLR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections.
 
Interactions
Tlr2 interacts with 53 markers (Mir16-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (93 annotations)
Process cell surface pattern recognition receptor signaling pathway, cellular response to bacterial lipopeptide, ...
Component cell body, cell projection, ...
Function diacyl lipopeptide binding, lipopeptide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (113)    Tissues (76)    Images (27)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 78
RT-PCR 35
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027995 (Evidence)
Entrez Gene24088 (Evidence)
UniGene87596
DFCITC1580205
DoTSDT.40177121, DT.94285732
NIA Mouse Gene IndexU024201
PDB3A7B, 3A7C, 2Z81, 2Z82, 3A79
Consensus CDS ProjectCCDS17435.1
International Mouse Knockout Project StatusTlr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 24088 NCBI Gene Model | MGI Sequence Detail 5337 C57BL/6J ±  kb
transcript NM_011905 RefSeq | MGI Sequence Detail 2874 C57BL/6 
polypeptide Q9QUN7 UniProt | EBI | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027185 Toll-like receptor 2
Protein Ontology PR:000001153 Toll-like receptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
(Latest) J:211658 Ji L, et al., Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-kappaB signaling pathways. FEBS Lett. 2014 Jun 5;588(12):2095-100
All references(868)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory