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Tlr2
Gene Detail
Symbol

Name
ID
Tlr2
toll-like receptor 2
MGI:1346060
Synonyms
Ly105
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:83836273-83841767 bp, - strand
From Ensembl annotation of GRCm38

  5495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr2

Human
homologs
Human Homolog TLR2, toll-like receptor 2
NCBI Gene ID 7097
neXtProt AC  NX_O60603
Human Synonyms  CD282, TIL4
Human Chr (Location)  4q32; chr4:153684252-153706091 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TLR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections.
 
Interactions
Tlr2 interacts with 53 markers (Mir16-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (113)    Tissues (76)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
RT-PCR 35
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027995 (Evidence)
Entrez Gene24088 (Evidence)
UniGene87596
DFCITC1580205
DoTSDT.40177121, DT.94285732
NIA Mouse Gene IndexU024201
PDB3A7C, 3A7B, 2Z82, 3A79, 2Z81
Consensus CDS ProjectCCDS17435.1
International Mouse Knockout Project StatusTlr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027995 Ensembl Gene Model | MGI Sequence Detail 5495 C57BL/6J ±  kb
transcript ENSMUST00000029623 Ensembl | MGI Sequence Detail 3013 Not Applicable 
polypeptide ENSMUSP00000029623 Ensembl | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027185 Toll-like receptor 2
Protein Ontology PR:000001153 Toll-like receptor 2
References
(Earliest) J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
(Latest) J:214756 Nackiewicz D, et al., TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6. Diabetologia. 2014 Aug;57(8):1645-54
All references(878)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory