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Tlr2
Gene Detail
Symbol

Name
ID
Tlr2
toll-like receptor 2
MGI:1346060
Synonyms
Ly105
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:83836272-83841767 bp, - strand
From VEGA annotation of GRCm38

  5496 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLR2
Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr2

Human
homologs
TLR2, toll-like receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7097
neXtProt AC: NX_O60603

Human Synonyms: CD282, TIL4

Human Chr (Location): 4q32; chr4:153684256-153706091 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TLR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections.
 
Interactions
Tlr2 interacts with 53 markers (Mir16-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (113)    Tissues (76)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
RT-PCR 35
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100485771 ; ZFIN tlr2    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051567 (Evidence)
Ensembl Gene Model ENSMUSG00000027995 (Evidence)
Entrez Gene 24088 (Evidence)
UniGene 87596
DFCI TC1580205
DoTS DT.94285732, DT.40177121
NIA Mouse Gene Index U024201
PDB 3A7B, 3A7C, 2Z81, 2Z82, 3A79
Consensus CDS Project CCDS17435.1
International Mouse Phenotyping Consortium Status Tlr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051567 VEGA Gene Model | MGI Sequence Detail 5496 C57BL/6J ±  kb
transcript OTTMUST00000130194 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000069825 VEGA | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027185 Toll-like receptor 2
Protein Ontology PR:000001153 Toll-like receptor 2
References
(Earliest) J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
(Latest) J:220345 Kumar P, et al., Mycobacterium indicus pranii induces dendritic cell activation, survival, and Th1/Th17 polarization potential in a TLR-dependent manner. J Leukoc Biol. 2015 Mar;97(3):511-20
All references(901)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory