Tlr2
Gene Detail

Symbol Name ID

Tlr2 toll-like receptor 2 MGI:1346060

Synonyms

Ly105

Feature Type

protein coding gene

Genetic Map

Chromosome 3

37.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:83836272-83841608 bp, - strand From NCBI annotation of GRCm38   5337 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr2

Human homologs

Human Homolog		TLR2, toll-like receptor 2
NCBI Gene ID		7097
neXtProt AC		NX_O60603
Human Synonyms		CD282, TIL4
Human Chr (Location)		4q32; chr4:154605441-154627243 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TLR2

Alleles and phenotypes

All alleles(7) : Targeted(6) Chemically induced(1)
 

Homozygous null mice demonstrate abnormal responses to bacterial and viral infections.

 

Gene Ontology (GO) classifications

All GO classifications: (91 annotations)

Process	cell surface pattern recognition receptor signaling pathway, cellular response to bacterial lipopeptide, ...
Component	cell body, cell projection, ...
Function	diacyl lipopeptide binding, Gram-positive bacterial cell surface binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (113)    Tissues (76)    Images (27)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	78
RT-PCR	35

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000027995 (Evidence)
Entrez Gene	24088 (Evidence)
UniGene	87596
DFCI	TC1580205
DoTS	DT.40177121, DT.94285732
NIA Mouse Gene Index	U024201
PDB	3A7B, 3A7C, 2Z81, 2Z82, 3A79
Consensus CDS Project	CCDS17435.1
International Mouse Knockout Project Status	Tlr2

Sequences

Length	Strain/Species
genomic	24088	NCBI Gene Model | MGI Sequence Detail	5337	C57BL/6J
transcript	NM_011905	RefSeq | MGI Sequence Detail	2874	C57BL/6
polypeptide	Q9QUN7	UniProt | EBI | MGI Sequence Detail	784	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR004075	Interleukin-1 receptor, type I/Toll precursor
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
InterPro	IPR017241	Toll-like receptor
Protein Ontology	PR:000001153	toll-like receptor 2
Protein Ontology	PR:000027272	toll-like receptor 2 (mouse)

Graphical View of Protein Domain Structure

References

(Earliest) J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
(Latest) J:194208 Montalbano AP, et al., Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. Endocrinology. 2013 Jan;154(1):483-98
All references(789)