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Tlr2
Gene Detail
Symbol

Name
ID
Tlr2
toll-like receptor 2
MGI:1346060
Synonyms
Ly105
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:83836272-83841767 bp, - strand
From VEGA annotation of GRCm38

  5496 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr2

Human
homologs
Human Homolog   TLR2, toll-like receptor 2
NCBI Gene ID 7097
neXtProt AC  NX_O60603
Human Synonyms  CD282, TIL4
Human Chr (Location)  4q32; chr4:153684252-153706091 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TLR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections.
 
Interactions
Tlr2 interacts with 53 markers (Mir16-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (113)    Tissues (76)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
RT-PCR 35
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000051567 (Evidence)
Ensembl Gene ModelENSMUSG00000027995 (Evidence)
Entrez Gene24088 (Evidence)
UniGene87596
DFCITC1580205
DoTSDT.40177121, DT.94285732
NIA Mouse Gene IndexU024201
PDB2Z81, 3A7B, 3A7C, 3A79, 2Z82
Consensus CDS ProjectCCDS17435.1
International Mouse Knockout Project StatusTlr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051567 VEGA Gene Model | MGI Sequence Detail 5496 C57BL/6J ±  kb
transcript OTTMUST00000130194 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000069825 VEGA | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027185 Toll-like receptor 2
Protein Ontology PR:000001153 Toll-like receptor 2
References
(Earliest) J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
(Latest) J:218134 Mariano VS, et al., Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity. PLoS One. 2014;9(6):e98512
All references(894)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory