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Symbol
Name
ID

Tlr2
toll-like receptor 2
MGI:1346060

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormality of metabolism/homeostasis	Decreased level of 1,5 anhydroglucitol in serum	Hyperglycemia	Diabetes mellitus	Ketoacidosis	Food intolerance	Decreased level of D-mannose in urine
Disease(s) Associated with TLR2	Abnormality of metabolism/homeostasis	Decreased level of 1,5 anhydroglucitol in serum	Hyperglycemia	Diabetes mellitus	Ketoacidosis	Food intolerance	Decreased level of D-mannose in urine
atopic dermatitis
Behcet's disease
type 1 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal response to cardiac infarction

increased insulin secretion

decreased macrophage nitric oxide production

abnormal circulating glucose level

abnormal circulating corticosterone level

decreased circulating corticosterone level

abnormal circulating insulin level

decreased circulating insulin level

decreased circulating leptin level

abnormal circulating pituitary hormone level

increased circulating adrenocorticotropin level

abnormal circulating lipid level

abnormal circulating cholesterol level

abnormal circulating LDL cholesterol level

decreased circulating VLDL cholesterol level

increased circulating free fatty acids level

decreased circulating interleukin-1 beta level

decreased circulating tumor necrosis factor level

decreased circulating alanine transaminase level

increased energy expenditure

abnormal glucose homeostasis

improved glucose tolerance

increased insulin sensitivity

abnormal chemokine level

abnormal interleukin level

abnormal tumor necrosis factor level

decreased cerebral infarct size

decreased susceptibility to kidney reperfusion injury

Availability

Mouse Genotype

Tlr2^tm1Aki/Tlr2^tm1Aki

*

Tlr2^tm1Kir/Tlr2^tm1Kir

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23