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Slc11a1
Gene Detail
Symbol

Name
ID
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275
Synonyms
Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Lsh, Nramp, Nramp1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)
Sequence Map
Chr1:74375195-74386062 bp, + strand
From VEGA annotation of GRCm38

  10868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SLC11A1
Protein SuperFamily: divalent metal ion transporter, NRAMP type
Gene Tree: Slc11a1

Human
homologs
SLC11A1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6556
neXtProt AC: NX_P49279

Human Synonyms: LSH, NRAMP, NRAMP1

Human Chr (Location): 2q35; chr2:218381766-218396894 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLC11A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(2) Targeted(4)
Incidental mutations (data from APF )
 
Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Slc11a1 interacts with 85 markers (Mir22, Mir30b, Mir30c-1, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (45)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 46
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(6) cDNA(25) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016632 (Evidence)
Ensembl Gene Model ENSMUSG00000026177 (Evidence)
Entrez Gene 18173 (Evidence)
UniGene 2913
DFCI TC1583294
DoTS DT.99843454, DT.97386549, DT.101725612
NIA Mouse Gene Index U000449
Consensus CDS Project CCDS15047.1
International Mouse Phenotyping Consortium Status Slc11a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016632 VEGA Gene Model | MGI Sequence Detail 10868 C57BL/6J ±  kb
transcript OTTMUST00000040229 VEGA | MGI Sequence Detail 2315 Not Applicable 
polypeptide OTTMUSP00000017968 VEGA | MGI Sequence Detail 548 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001046 Natural resistance-associated macrophage like
Protein Ontology PR:000002994 natural resistance-associated macrophage protein 1
References
(Earliest) J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
(Latest) J:217577 Sivick KE, et al., Toll-like receptor-deficient mice reveal how innate immune signaling influences Salmonella virulence strategies. Cell Host Microbe. 2014 Feb 12;15(2):203-13
All references(200)
Other
accession IDs
MGD-MRK-11510, MGD-MRK-11511, MGD-MRK-11891, MGD-MRK-1520, MGD-MRK-16714, MGD-MRK-24163, MGI:103283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory