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Slc11a1
Gene Detail
Symbol

Name
ID
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275
Synonyms
Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Lsh, Nramp, Nramp1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)
Sequence Map
Chr1:74375195-74386062 bp, + strand
From VEGA annotation of GRCm38

  10868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: divalent metal ion transporter, NRAMP type
Gene Tree: Slc11a1

Human
homologs
Human Homolog SLC11A1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
NCBI Gene ID 6556
neXtProt AC  NX_P49279
Human Synonyms  LSH, NRAMP, NRAMP1
Human Chr (Location)  2q35; chr2:218382029-218396894 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC11A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(2) Targeted(4)
Incidental mutations (data from APF )
 
Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Slc11a1 interacts with 85 markers (Mir22, Mir30b, Mir30c-1, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (45)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 46
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(6) cDNA(25) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016632 (Evidence)
Ensembl Gene ModelENSMUSG00000026177 (Evidence)
Entrez Gene18173 (Evidence)
UniGene2913
DFCITC1583294
DoTSDT.101725612, DT.97386549, DT.99843454
NIA Mouse Gene IndexU000449
Consensus CDS ProjectCCDS15047.1
International Mouse Knockout Project StatusSlc11a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016632 VEGA Gene Model | MGI Sequence Detail 10868 C57BL/6J ±  kb
transcript OTTMUST00000040229 VEGA | MGI Sequence Detail 2315 Not Applicable 
polypeptide OTTMUSP00000017968 VEGA | MGI Sequence Detail 548 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001046 Natural resistance-associated macrophage like
Protein Ontology PR:000002994 natural resistance-associated macrophage protein 1
References
(Earliest) J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
(Latest) J:195299 Hedges JF, et al., Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation. J Immunol. 2013 Apr 15;190(8):4263-73
All references(204)
Other
accession IDs
MGD-MRK-11510, MGD-MRK-11511, MGD-MRK-11891, MGD-MRK-1520, MGD-MRK-16714, MGD-MRK-24163, MGI:103283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory