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Slc11a1 Gene Detail
Summary
  • Symbol
    Slc11a1
  • Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
  • Synonyms
    Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Ity1, Lsh, Nramp, Nramp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345275
    NCBI Gene: 18173
  • Gene Overview
    MyGene.info: SLC11A1
Location & Maps
more
  • Sequence Map
    Chr1:74375195-74386062 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10868 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    64 experiments
Homology
more
  • Human Ortholog
    SLC11A1, solute carrier family 11 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC11A1, solute carrier family 11 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LSH, NRAMP, NRAMP1
  • Links
    NCBI Gene ID: 6556
    neXtProt AC: NX_P49279

  • Chr Location
    2q35; chr2:218381766-218396894 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human SLC11A1 associations

Human Disease Mouse Models
       Buruli Ulcer, Susceptibility to   OMIM: 610446
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Slc11a1
  • Incidental Mutations
    APF
Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016632 VEGA Gene Model | MGI Sequence Detail 10868 C57BL/6J ±  kb
transcript OTTMUST00000040229 VEGA | MGI Sequence Detail 2315 Not Applicable  
polypeptide OTTMUSP00000017968 VEGA | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002994 natural resistance-associated macrophage protein 1
  • InterPro Domains
    IPR001046 NRAMP family
Molecular
Reagents
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  • All nucleic 33
    Genomic 6
    cDNA 25
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11510, MGD-MRK-11511, MGD-MRK-11891, MGD-MRK-1520, MGD-MRK-16714, MGD-MRK-24163, MGI:103283
References
more
  • Summaries
    All 198
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 35
    Phenotypes 93
  • Earliest
    J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
  • Latest
    J:223095 Loomis WP, et al., Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background. PLoS One. 2014;9(10):e111763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory