Slc11a1
Gene Detail

Symbol Name ID

Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 MGI:1345275

Synonyms

Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Lsh, Nramp, Nramp1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)

Sequence Map

Chr1:74375203-74386062 bp, + strand From VEGA annotation of GRCm38   10860 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:73884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: divalent metal ion transporter, NRAMP type
Gene Tree: Slc11a1

Human homologs

Human Homolog		SLC11A1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
NCBI Gene ID		6556
neXtProt AC		NX_P49279
Human Synonyms		LSH, NRAMP, NRAMP1
Human Chr (Location)		2q35; chr2:219246752-219261617 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC11A1

Alleles and phenotypes

All alleles(6) : Targeted(4) Spontaneous(2)
 

Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (77 annotations)

Process	activation of protein kinase activity, antigen processing and presentation of peptide antigen, ...
Component	cell outer membrane, endosome membrane, ...
Function	manganese ion transmembrane transporter activity, metal ion:hydrogen antiporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (45)    Images (2)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	1
RT-PCR	46

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(6) cDNA(25) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016632 (Evidence)
Ensembl Gene Model	ENSMUSG00000026177 (Evidence)
Entrez Gene	18173 (Evidence)
UniGene	2913
DFCI	TC1583294
DoTS	DT.101725612, DT.97386549, DT.99843454
NIA Mouse Gene Index	U000449
Consensus CDS Project	CCDS15047.1
International Mouse Knockout Project Status	Slc11a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016632	VEGA Gene Model | MGI Sequence Detail	10860	C57BL/6J
transcript	OTTMUST00000040229	VEGA | MGI Sequence Detail	2315	Not Applicable
polypeptide	OTTMUSP00000017968	VEGA | MGI Sequence Detail	548	Not Applicable

All sequences(43) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001046	Natural resistance-associated macrophage protein
Protein Ontology	PR:000002994	natural resistance-associated macrophage protein 1

References

(Earliest) J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
(Latest) J:195299 Hedges JF, et al., Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation. J Immunol. 2013 Apr 15;190(8):4263-73
All references(204)

Other accession IDs

MGD-MRK-11510, MGD-MRK-11511, MGD-MRK-11891, MGD-MRK-1520, MGD-MRK-16714, MGD-MRK-24163, MGI:103283