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Slc11a1 Gene Detail
Summary
  • Symbol
    Slc11a1
  • Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
  • Synonyms
    Bcg, host resistance locus Bcg/Ity/Lsh, ity, Ity, Ity1, Lsh, Nramp, Nramp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345275
    NCBI Gene: 18173
  • Gene Overview
    MyGene.info: SLC11A1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74375195-74386062 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    64 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345275
protein coding gene Chr1:74375014-74386062 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016149
protein coding gene Chr1:74972148-74984459 (+)
A/J MGP_AJ_G0016132
protein coding gene Chr1:72346983-72358199 (+)
AKR/J MGP_AKRJ_G0016089
protein coding gene Chr1:74358815-74369707 (+)
BALB/cJ MGP_BALBcJ_G0016087
protein coding gene Chr1:72415486-72426160 (+)
C3H/HeJ MGP_C3HHeJ_G0015918
protein coding gene Chr1:74690061-74703154 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016540
protein coding gene Chr1:77887287-77899669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014261
protein coding gene Chr1:67933715-67944720 (+)
CAST/EiJ MGP_CASTEiJ_G0015502
protein coding gene Chr1:74010226-74030576 (+)
CBA/J MGP_CBAJ_G0015891
protein coding gene Chr1:80417158-80428663 (+)
DBA/2J MGP_DBA2J_G0015992
protein coding gene Chr1:71680560-71691533 (+)
FVB/NJ MGP_FVBNJ_G0015995
protein coding gene Chr1:70859327-70870645 (+)
LP/J MGP_LPJ_G0016064
protein coding gene Chr1:76076864-76088733 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016015
protein coding gene Chr1:83831970-83847285 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016587
protein coding gene Chr1:74425350-74436227 (+)
PWK/PhJ MGP_PWKPhJ_G0015289
protein coding gene Chr1:71129737-71142912 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015067
protein coding gene Chr1:73792853-73809801 (+)
WSB/EiJ MGP_WSBEiJ_G0015564
protein coding gene Chr1:74218426-74231225 (+)



Homology
more
  • Human Ortholog
    SLC11A1, solute carrier family 11 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC11A1, solute carrier family 11 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LSH, NRAMP, NRAMP1
  • Links
    NCBI Gene ID: 6556
    neXtProt AC: NX_P49279
    UniProt: P49279

  • Chr Location
    2q35; chr2:218381766-218396894 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Slc11a1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026177 Ensembl Gene Model | MGI Sequence Detail 10868 C57BL/6J ±  kb
transcript ENSMUST00000027368 Ensembl | MGI Sequence Detail 2315 Not Applicable  
polypeptide ENSMUSP00000027368 Ensembl | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 6
    cDNA 26
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11510, MGD-MRK-11511, MGD-MRK-11891, MGD-MRK-1520, MGD-MRK-16714, MGD-MRK-24163, MGI:103283
References
more
  • Summaries
    All 223
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 36
    Phenotypes 98
  • Earliest
    J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
  • Latest
    J:259759 Wu KC, et al., The critical role of Nramp1 in degrading alpha-synuclein oligomers in microglia under iron overload condition. Neurobiol Dis. 2017 Aug;104:61-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory