Slc11a1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275

10 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^r/Slc11a1^r involves: 129S2/SvPas	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s B6.129S2-Casp1^tm1Flv	cecum inflammation	J:124378
	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s involves: 129/Sv * 129S2/SvPas * C57BL/6	increased susceptibility to bacterial infection	J:112400
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s B6.129S2-Casp1^tm1Sesh Casp4^del	abnormal macrophage physiology	J:112400
	increased susceptibility to bacterial infection	J:112400
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r BXH2/TyJ	abnormal myelopoiesis	J:97931
	decreased interferon-gamma secretion	J:97931
	decreased interleukin-12 secretion	J:97931
	enlarged spleen	J:97931
	increased chronic myelocytic leukemia incidence	J:97931
	increased susceptibility to bacterial infection	J:97931
	premature death	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: A/J * BXH2/TyJ	increased chronic myelocytic leukemia incidence	J:97931
	premature death	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BXH2/TyJ * C3H/HeJ	enlarged spleen	J:97931
	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BXH2/TyJ * C57BL/6J	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s involves: BXH2/TyJ * C57BL/6J	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^s/Slc11a1^s involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Nlrc4^tm1Gln/Nlrc4^tm1Gln Slc11a1^s/Slc11a1^s B6.129S5-Nlrc4^tm1Gln	increased susceptibility to bacterial infection	J:124378
Nlrp3^tm1Flv/Nlrp3^tm1Flv Slc11a1^s/Slc11a1^s B6.129S5-Nlrp3^tm1Flv	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Pycard^tm1Flv/Pycard^tm1Flv Slc11a1^s/Slc11a1^s B6.129S5-Pycard^tm1Flv	increased susceptibility to bacterial infection	J:124378

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23