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Grem2 Gene Detail
Summary
  • Symbol
    Grem2
  • Name
    gremlin 2, DAN family BMP antagonist
  • Synonyms
    Prdc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344367
    NCBI Gene: 23893
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:174833785-174921819 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 81.08 cM, cytoband H3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    895 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344367
protein coding gene Chr1:174833785-174921915 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016834
protein coding gene Chr1:180914751-181012007 (-)
A/J MGP_AJ_G0016813
protein coding gene Chr1:173625239-173720947 (-)
AKR/J MGP_AKRJ_G0016779
protein coding gene Chr1:178816897-178913486 (-)
BALB/cJ MGP_BALBcJ_G0016771
protein coding gene Chr1:174149380-174240566 (-)
C3H/HeJ MGP_C3HHeJ_G0016596
protein coding gene Chr1:179425298-179514909 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017236
protein coding gene Chr1:186965601-187053368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014941
protein coding gene Chr1:164978014-165072323 (-)
CAST/EiJ MGP_CASTEiJ_G0016177
protein coding gene Chr1:178782191-178879281 (-)
CBA/J MGP_CBAJ_G0016570
protein coding gene Chr1:193782218-193882364 (-)
DBA/2J MGP_DBA2J_G0016675
protein coding gene Chr1:172486045-172576152 (-)
FVB/NJ MGP_FVBNJ_G0016672
protein coding gene Chr1:170619709-170709496 (-)
LP/J MGP_LPJ_G0016751
protein coding gene Chr1:182091364-182182513 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016704
protein coding gene Chr1:200967663-201063765 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017271
protein coding gene Chr1:178610185-178701573 (-)
PWK/PhJ MGP_PWKPhJ_G0015964
protein coding gene Chr1:171572931-171664783 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015741
protein coding gene Chr1:177615490-177706395 (-)
WSB/EiJ MGP_WSBEiJ_G0016239
protein coding gene Chr1:178784388-178877460 (-)



Homology
more
  • Human Ortholog
    GREM2, gremlin 2, DAN family BMP antagonist
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GREM2, gremlin 2, DAN family BMP antagonist
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CKTSF1B2, DAND3, PRDC, STHAG9
  • Links
    NCBI Gene ID: 64388
    neXtProt AC: NX_Q9H772
    UniProt: Q9H772

  • Chr Location
    1q43; chr1:240489573-240612372 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show small and malformed mandibular and maxillary incisors and slightly increased bone mineral density but appear otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050069 Ensembl Gene Model | MGI Sequence Detail 88035 C57BL/6J ±  kb
    transcript ENSMUST00000055294 Ensembl | MGI Sequence Detail 3745 Not Applicable  
    polypeptide ENSMUSP00000049640 Ensembl | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 9
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:48401 Minabe-Saegusa C, et al., Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ. 1998 Jun;40(3):343-53
    • Latest
      J:250034 Sanders LN, et al., BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Circ Res. 2016 Jul 22;119(3):434-49

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory