48 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grem2em1(IMPC)Bay/Grem2+ C57BL/6N-Grem2em1(IMPC)Bay/Bay	dilated heart left ventricle	J:211773
	increased cardiac stroke volume	J:211773
Grem2em1(IMPC)Bay/Grem2em1(IMPC)Bay C57BL/6N-Grem2em1(IMPC)Bay/Bay	preweaning lethality, incomplete penetrance	J:211773
Grem2em1Stpg/Grem2em1Stpg involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J	abnormal circulating hormone level	J:318711
	abnormal diestrus	J:318711
	abnormal estrous cycle	J:318711
	abnormal hormone level	J:318711
	abnormal ovary physiology	J:318711
	abnormal secondary ovarian follicle morphology	J:318711
	decreased corpora lutea number	J:318711
	decreased litter size	J:318711
	decreased tertiary ovarian follicle number	J:318711
	normal homeostasis/metabolism phenotype	J:318711
	increased primary ovarian follicle number	J:318711
	ovary inflammation	J:318711
	prolonged diestrus	J:318711
	prolonged metestrus	J:318711
	reduced female fertility	J:318711
	short estrus	J:318711
	short lower incisors	J:318711
	short upper incisors	J:318711
Grem2tm1Akh/Grem2tm1Akh involves: 129/Sv * C57BL/6	abnormal chemokine level	J:250034
	abnormal response to myocardial ischemic injury	J:250034
	normal cardiovascular system phenotype	J:250034
	decreased cardiac muscle contractility	J:250034
	increased heart rate	J:250034
	increased inflammatory response	J:250034
	increased interleukin-10 secretion	J:250034
	increased leukocyte cell number	J:250034
	increased transforming growth factor beta level	J:250034
Grem2tm1Lex/Grem2tm1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal dentin morphology	J:227246
	abnormal incisor morphology	J:227246
	abnormal molar cusp morphology	J:227246
	abnormal tooth wear	J:227246
	normal behavior/neurological phenotype	J:227246
	brittle teeth	J:227246
	normal homeostasis/metabolism phenotype	J:227246
	normal immune system phenotype	J:227246
	increased bone mineral density	J:227246
	increased bone mineral density of femur	J:227246
	reduced enamel thickness	J:227246
	small lower incisors	J:227246
	small mandible	J:227246
	small upper incisors	J:227246
	normal vision/eye phenotype	J:227246
Tg(Myh6-Grem2)1Akh/0 involves: C57BL/6	abnormal response to myocardial ischemic injury	J:250034
	normal cardiovascular system phenotype	J:250034
	decreased inflammatory response	J:250034
	decreased interleukin-10 secretion	J:250034
	decreased transforming growth factor beta level	J:250034
	increased cardiac muscle contractility	J:250034