Grem2^em1Stpg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grem2^em1Stpg
• Name: gremlin 2, DAN family BMP antagonist; endonuclease-mediated mutation 1, Stephanie A Pangas
• MGI ID: MGI:6871050
• Synonyms: Grem2^-
• Gene: Grem2 Location: Chr1:174661351-174749385 bp, - strand Genetic Position: Chr1, 81.08 cM, cytoband H3
• Alliance: Grem2^em1Stpg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 deleted the open reading frame. The "P2" parental line, containing the larger deletion, was selected from two founder lines with similar incisor and fertility defects for further characterization. qPCR analysis confirmed the complete absence of mRNA expression in ovary and lung tissue from homozygous mutant mice. (J:318711)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem2 Mutation: 15 strains or lines available

References

• Original: J:318711 Rydze RT, et al., Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice. Biol Reprod. 2021 Nov 15;105(5):1205-1220
• All: 1 reference(s)