Grem2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Grem2^tm1Lex
• Name: gremlin 2, DAN family BMP antagonist; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5702891
• Synonyms: Grem2^-
• Gene: Grem2 Location: Chr1:174661351-174749385 bp, - strand Genetic Position: Chr1, 81.08 cM, cytoband H3
• Alliance: Grem2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227246
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The coding portion of exon 2 was replaced with a lacZ gene and neomycin selection cassette. (J:227246)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem2 Mutation: 15 strains or lines available

References

• Original: J:227246 Vogel P, et al., Malformation of incisor teeth in Grem2(-)/(-) mice. Vet Pathol. 2015 Jan;52(1):224-9
• All: 2 reference(s)