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Symbol
Name
ID
Grem2
gremlin 2, DAN family BMP antagonist
MGI:1344367
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
Sparse scalp hair
Aplasia of the maxilla
Short face
Eclabion
Abnormal dental morphology
Short dental root
Taurodontia
Peg-shaped maxillary lateral incisors
Abnormal primary molar morphology
Microdontia
Agenesis of central incisor
Agenesis of lateral incisor
Agenesis of maxillary lateral incisor
Agenesis of permanent teeth
Tooth agenesis
Anodontia
Hypodontia
Oligodontia
Oligodontia of primary teeth
Selective tooth agenesis
Agenesis of molar
Agenesis of permanent molar
Agenesis of first permanent molar tooth
Agenesis of premolar
Agenesis of mandibular premolar
Abnormality of canine
Delayed eruption of teeth
Delayed eruption of permanent teeth
Enamel hypoplasia
Hypoplasia of teeth
Abnormality of primary teeth
Dental malocclusion
Widely spaced teeth
Orofacial cleft
Impaired mastication
Sparse eyebrow
Short eyelashes
Disease(s) Associated with GREM2
tooth agenesis

Mouse Phenotypes
abnormal incisor morphology
small lower incisors
short lower incisors
small upper incisors
short upper incisors
abnormal molar cusp morphology
abnormal dentin morphology
reduced enamel thickness
abnormal tooth wear
brittle teeth
small mandible
Availability Mouse Genotype
Grem2em1Stpg/Grem2em1Stpg
Grem2tm1Lex/Grem2tm1Lex

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory