Msh6
Gene Detail

Symbol Name ID

Msh6 mutS homolog 6 (E. coli) MGI:1343961

Synonyms

GTBP, Gtmbp, Msh6

Feature Type

protein coding gene

Genetic Map

Chromosome 17

57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:87975050-87990883 bp, + strand From Ensembl annotation of GRCm38   15834 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA mismatch repair protein Msh6
Gene Tree: Msh6

Human homologs

Human Homolog		MSH6, mutS homolog 6 (E. coli)
NCBI Gene ID		2956
neXtProt AC		NX_P52701
Human Synonyms		GTBP, HNPCC5, HSAP
Human Chr (Location)		2p16; chr2:48010221-48034092 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MSH6

Alleles and phenotypes

All alleles(47) : Targeted(6) Gene trapped(41)
 

Mice homozygous for a knock-out allele exhibit premature death and are predisposed to tumor formation.

 

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	ATP catabolic process, determination of adult lifespan, ...
Component	MutSalpha complex, nuclear chromatin
Function	ADP binding, ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (70)    Tissues (32)    Images (1)
Theiler Stages: 2, 3, 4, 5, 10, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	8
Northern blot	11
RT-PCR	51

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000005370 (Evidence)
Entrez Gene	17688 (Evidence)
DFCI	TC1573024
NIA Mouse Gene Index	U018326
Consensus CDS Project	CCDS29021.1
International Mouse Knockout Project Status	Msh6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000005370	Ensembl Gene Model | MGI Sequence Detail	15834	C57BL/6J
transcript	ENSMUST00000005503	Ensembl | MGI Sequence Detail	4254	Not Applicable
polypeptide	ENSMUSP00000005503	Ensembl | MGI Sequence Detail	1358	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017261	DNA mismatch repair protein Msh6
InterPro	IPR007861	DNA mismatch repair protein MutS, clamp
InterPro	IPR007860	DNA mismatch repair protein MutS, connector domain
InterPro	IPR007696	DNA mismatch repair protein MutS, core
InterPro	IPR000432	DNA mismatch repair protein MutS, C-terminal
InterPro	IPR015536	DNA mismatch repair protein MutS-homologue MSH6
InterPro	IPR007695	DNA mismatch repair protein MutS-like, N-terminal
InterPro	IPR016151	DNA mismatch repair protein MutS, N-terminal
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR000313	PWWP
Protein Ontology	PR:000010670	DNA mismatch repair protein Msh6

References

(Earliest) J:43884 Papadopoulos N, et al., Mutations of GTBP in genetically unstable cells [see comments]. Science. 1995 Jun 30;268(5219):1915-7
(Latest) J:192085 Bourn RL, et al., Pms2 suppresses large expansions of the (GAA.TTC)n sequence in neuronal tissues. PLoS One. 2012;7(10):e47085
All references(70)

Other accession IDs

MGD-MRK-35056, MGI:106600, MGI:2147004, MGI:2147080