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Msh6
Gene Detail
 Symbol
Name
ID
Msh6
mutS homolog 6 (E. coli)
MGI:1343961
Synonyms GTBP, Gtmbp, Msh6
Feature Type protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:87975050-87990883 bp, + strand
From Ensembl annotation of GRCm38

  15834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA mismatch repair protein Msh6
Gene Tree: Msh6

Human
homologs
Human Homolog MSH6, mutS homolog 6
NCBI Gene ID 2956
neXtProt AC  NX_P52701
Human Synonyms  GTBP, GTMBP, HNPCC5, HSAP, p160
Human Chr (Location)  2p16; chr2:47783082-47806953 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MSH6
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Gene trapped(39) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit premature death and are predisposed to tumor formation.
 
Interactions
Msh6 interacts with 66 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process ATP catabolic process, cellular response to DNA damage stimulus, ...
Component chromosome, cytoplasm, ...
Function ADP binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (63)    Tissues (28)    Images (1)
Theiler Stages: 2, 3, 4, 5, 10, 17, 20, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 8
Northern blot 11
RT-PCR 44
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000005370 (Evidence)
Entrez Gene17688 (Evidence)
DFCITC1573024
NIA Mouse Gene IndexU018326
Consensus CDS ProjectCCDS29021.1
International Mouse Knockout Project StatusMsh6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005370 Ensembl Gene Model | MGI Sequence Detail 15834 C57BL/6J ±  kb
transcript ENSMUST00000005503 Ensembl | MGI Sequence Detail 4254 Not Applicable 
polypeptide ENSMUSP00000005503 Ensembl | MGI Sequence Detail 1358 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017261 DNA mismatch repair protein Msh6
InterPro IPR007861 DNA mismatch repair protein MutS, clamp
InterPro IPR007860 DNA mismatch repair protein MutS, connector domain
InterPro IPR007696 DNA mismatch repair protein MutS, core
InterPro IPR000432 DNA mismatch repair protein MutS, C-terminal
InterPro IPR015536 DNA mismatch repair protein MutS-homologue MSH6
InterPro IPR007695 DNA mismatch repair protein MutS-like, N-terminal
InterPro IPR016151 DNA mismatch repair protein MutS, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000313 PWWP
Protein Ontology PR:000010670 DNA mismatch repair protein Msh6
References (Earliest) J:43884 Papadopoulos N, et al., Mutations of GTBP in genetically unstable cells [see comments]. Science. 1995 Jun 30;268(5219):1915-7
(Latest) J:198961 Ghodgaonkar MM, et al., Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell. 2013 May 9;50(3):323-32
All references(71)
Other
accession IDs
MGD-MRK-35056, MGI:106600, MGI:2147004, MGI:2147080

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory