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Ndufs4
Gene Detail
 Symbol
Name
ID
Ndufs4
NADH dehydrogenase (ubiquinone) Fe-S protein 4
MGI:1343135
Synonyms 6720411N02Rik, C1-18k
Feature Type protein coding gene
Genetic Map
Chromosome 13
64.12 cM, cytoband D2.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:114287795-114388094 bp, - strand
From NCBI annotation of GRCm38

  100300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NADH dehydrogenase (ubiquinone) iron-sulfur protein 4
Gene Tree: Ndufs4

Human
homologs
Human Homolog NDUFS4, NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NCBI Gene ID 4724
neXtProt AC  NX_O43181
Human Synonyms  AQDQ, CI-18
Human Chr (Location)  5q11.1; chr5:53560635-53683341 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NDUFS4
Alleles
and
phenotypes
All alleles(46) : Targeted(6) Gene trapped(39) Spontaneous(1)
 
Mice homozygous for a null allele exhibit growth retardation, lethargy, loss of motor skills, blindness and decreased mitochondrial CI complex activity beginning at 5 weeks of age followed by death at week 7.
 
Human Diseases Modeled Using Mouse Ndufs4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, cAMP-mediated signaling, ...
Component membrane, mitochondrial inner membrane, ...
Function NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity, acting on NAD(P)H
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (101)    Tissues (101)    Images (10)
Theiler Stages: 3, 4, 5, 22
Assay TypeResults
RNA in situ 94
RT-PCR 7
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021764 (Evidence)
Entrez Gene17993 (Evidence)
DFCITC1575609, TC1636758, TC1658528, TC1666262, TC1722617
DoTSDT.101311094, DT.110961286, DT.40164646, DT.537875
NIA Mouse Gene IndexU035198
Consensus CDS ProjectCCDS49368.1
International Mouse Knockout Project StatusNdufs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17993 NCBI Gene Model | MGI Sequence Detail 100300 C57BL/6J ±  kb
transcript NM_010887 RefSeq | MGI Sequence Detail 1534 C57BL/6 
polypeptide Q9CXZ1 UniProt | EBI | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(884 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006885 NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial
Protein Ontology PR:000011099 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:54917 Murdock DG, et al., Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J Biol Chem. 1999 May 14;274(20):14429-33
(Latest) J:205304 Lee KK, et al., Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes. Free Radic Biol Med. 2013 Dec;65:584-94
All references(57)
Other
accession IDs
MGI:1924978

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory