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Ndufs4
Gene Detail
Symbol

Name
ID
Ndufs4
NADH dehydrogenase (ubiquinone) Fe-S protein 4
MGI:1343135
Synonyms
6720411N02Rik, C1-18k
Feature Type
protein coding gene
Genetic Map
Chromosome 13
64.12 cM, cytoband D2.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:114287795-114388094 bp, - strand
From Ensembl annotation of GRCm38

  100300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NADH dehydrogenase (ubiquinone) iron-sulfur protein 4
Gene Tree: Ndufs4

Human
homologs
Human Homolog NDUFS4, NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NCBI Gene ID 4724
neXtProt AC  NX_O43181
Human Synonyms  AQDQ, CI-18
Human Chr (Location)  5q11.1; chr5:53560635-53683341 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NDUFS4
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(39) Spontaneous(1) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit growth retardation, lethargy, loss of motor skills, blindness and decreased mitochondrial CI complex activity beginning at 5 weeks of age followed by death at week 7.
 
Human Diseases Modeled Using Mouse Ndufs4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Interactions
Ndufs4 interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (97)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021764 (Evidence)
Entrez Gene17993 (Evidence)
DFCITC1722617, TC1666262, TC1658528, TC1636758, TC1575609
DoTSDT.110961286, DT.101311094, DT.40164646, DT.537875
NIA Mouse Gene IndexU035198
Consensus CDS ProjectCCDS49368.1
International Mouse Knockout Project StatusNdufs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021764 Ensembl Gene Model | MGI Sequence Detail 100300 C57BL/6J ±  kb
transcript ENSMUST00000022286 Ensembl | MGI Sequence Detail 1534 Not Applicable 
polypeptide ENSMUSP00000022286 Ensembl | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(884 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006885 NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial
Protein Ontology PR:000011099 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
References
(Earliest) J:54917 Murdock DG, et al., Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J Biol Chem. 1999 May 14;274(20):14429-33
(Latest) J:210644 Li J, et al., Rapamycin: one drug, many effects. Cell Metab. 2014 Mar 4;19(3):373-9
All references(59)
Disease annotation references (3)
Other
accession IDs
MGI:1924978

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory