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Spop
Gene Detail
 Symbol
Name
ID
Spop
speckle-type POZ protein
MGI:1343085
Synonyms Pcif1, TEF2
Feature Type protein coding gene
Genetic Map
Chromosome 11
59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:95414080-95493406 bp, + strand
From VEGA annotation of GRCm38

  79327 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Spop

Human
homologs
Human Homolog SPOP, speckle-type POZ protein
NCBI Gene ID 8405
neXtProt AC  NX_O43791
Human Synonyms  BTBD32, TEF2
Human Chr (Location)  17q21.33; chr17:49598884-49678163 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(16) Targeted(7)
Genomic Mutations involving Spop (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit increased beta cell area and lethality between E18.5 and P1.
 
Interactions
Spop interacts with 246 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process glucose homeostasis, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, ...
Component Cul3-RING ubiquitin ligase complex, nuclear speck, ...
Function protein binding, RNA polymerase II transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(131)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(132) Genomic(1) cDNA(131)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001659 (Evidence)
Ensembl Gene ModelENSMUSG00000057522 (Evidence)
Entrez Gene20747 (Evidence)
UniGene285454
DFCITC1572964, TC1659446
DoTSDT.101395141, DT.87072907, DT.97404291, DT.97412675
NIA Mouse Gene IndexU013221
Consensus CDS ProjectCCDS36286.1
International Mouse Knockout Project StatusSpop
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001659 VEGA Gene Model | MGI Sequence Detail 79327 C57BL/6J ±  kb
transcript OTTMUST00000003283 VEGA | MGI Sequence Detail 3063 Not Applicable 
polypeptide OTTMUSP00000001580 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(546 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR002083 MATH
InterPro IPR008974 TRAF-like
Protein Ontology PR:000015559 speckle-type POZ protein
References (Earliest) J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)
Other
accession IDs
MGI:2144110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory