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Spop Gene Detail
Summary
  • Symbol
    Spop
  • Name
    speckle-type POZ protein
  • Synonyms
    Pcif1, TEF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343085
    NCBI Gene: 20747
  • Gene Overview
    MyGene.info: SPOP
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95414080-95493406 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343085
protein coding gene Chr11:95414063-95493410 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018983
protein coding gene Chr11:97610871-97694682 (+)
A/J MGP_AJ_G0018951
protein coding gene Chr11:93679331-93760755 (+)
AKR/J MGP_AKRJ_G0018921
protein coding gene Chr11:96576886-96657956 (+)
BALB/cJ MGP_BALBcJ_G0018924
protein coding gene Chr11:94148172-94236375 (+)
C3H/HeJ MGP_C3HHeJ_G0018738
protein coding gene Chr11:96697398-96783064 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019376
protein coding gene Chr11:100682095-100765406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017007
protein coding gene Chr11:91162276-91241060 (+)
CAST/EiJ MGP_CASTEiJ_G0018292
protein coding gene Chr11:97506722-97587981 (+)
CBA/J MGP_CBAJ_G0018709
protein coding gene Chr11:104795884-104883772 (+)
DBA/2J MGP_DBA2J_G0018817
protein coding gene Chr11:93248917-93328929 (+)
FVB/NJ MGP_FVBNJ_G0018806
protein coding gene Chr11:92718441-92799286 (+)
LP/J MGP_LPJ_G0018887
protein coding gene Chr11:98183453-98268408 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018833
protein coding gene Chr11:104828130-104918594 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019416
protein coding gene Chr11:96841587-96922724 (+)
PWK/PhJ MGP_PWKPhJ_G0018063
protein coding gene Chr11:94177382-94258683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017852
protein coding gene Chr11:96529855-96612184 (+)
WSB/EiJ MGP_WSBEiJ_G0018341
protein coding gene Chr11:96760171-96847079 (+)



Homology
more
  • Human Ortholog
    SPOP, speckle type BTB/POZ protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPOP, speckle type BTB/POZ protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTBD32, TEF2
  • Links
    NCBI Gene ID: 8405
    neXtProt AC: NX_O43791
    UniProt: O43791

  • Chr Location
    17q21.33; chr17:49598884-49678163 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68354
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPOP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 5 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased beta cell area and lethality between E18.5 and P1.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057522 Ensembl Gene Model | MGI Sequence Detail 79327 C57BL/6J ±  kb
    transcript ENSMUST00000107722 Ensembl | MGI Sequence Detail 3063 Not Applicable  
    polypeptide ENSMUSP00000103350 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 1
      cDNA 132
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144110
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
    • Latest
      J:262476 Hai L, et al., Uterine function in the mouse requires speckle-type poz protein. Biol Reprod. 2018 Jun 1;98(6):856-869

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory