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Spop
Gene Detail
Symbol

Name
ID
Spop
speckle-type POZ protein
MGI:1343085
Synonyms
Pcif1, TEF2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:95414080-95493406 bp, + strand
From VEGA annotation of GRCm38

  79327 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPOP
Gene Tree: Spop

Human
homologs
SPOP, speckle-type POZ protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8405
neXtProt AC: NX_O43791

Human Synonyms: BTBD32, TEF2

Human Chr (Location): 17q21.33; chr17:49598884-49678163 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(16) Targeted(8)
Genomic Mutations involving Spop (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit increased beta cell area and lethality between E18.5 and P1.
 
Interactions
Spop interacts with 245 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase spop ; ZFIN spop    NEW 
Molecular
reagents
All nucleic(132) Genomic(1) cDNA(131)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001659 (Evidence)
Ensembl Gene Model ENSMUSG00000057522 (Evidence)
Entrez Gene 20747 (Evidence)
UniGene 285454
DFCI TC1572964, TC1659446
DoTS DT.101395141, DT.87072907, DT.97404291, DT.97412675
NIA Mouse Gene Index U013221
Consensus CDS Project CCDS36286.1
International Mouse Phenotyping Consortium Status Spop
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001659 VEGA Gene Model | MGI Sequence Detail 79327 C57BL/6J ±  kb
transcript OTTMUST00000003283 VEGA | MGI Sequence Detail 3063 Not Applicable 
polypeptide OTTMUSP00000001580 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(546 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000210 BTB/POZ domain
InterPro IPR002083 MATH/TRAF domain
InterPro IPR011333 POZ domain
InterPro IPR008974 TRAF-like
Protein Ontology PR:000015559 speckle-type POZ protein
References
(Earliest) J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGI:2144110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory