Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of transcription by RNA polymerase II; and positive regulation of apoptotic process. Located in nuclear speck. Is expressed in cerebral cortex ventricular layer; cortical plate; lung; metanephros; and pancreas. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein).