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Aicda Gene Detail
Summary
  • Symbol
    Aicda
  • Name
    activation-induced cytidine deaminase
  • Synonyms
    Aid
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342279
    NCBI Gene: 11628
  • Gene Overview
    MyGene.info: AICDA
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122553809-122564180 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.65 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342279
protein coding gene Chr6:122553801-122564180 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031228
protein coding gene Chr6:125646534-125658948 (+)
A/J MGP_AJ_G0031197
protein coding gene Chr6:120893441-120903828 (+)
AKR/J MGP_AKRJ_G0031126
protein coding gene Chr6:124236814-124247175 (+)
BALB/cJ MGP_BALBcJ_G0031206
protein coding gene Chr6:120581233-120591642 (+)
C3H/HeJ MGP_C3HHeJ_G0030925
protein coding gene Chr6:124183352-124194359 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031665
protein coding gene Chr6:128941073-128953187 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028824
protein coding gene Chr6:117501796-117512418 (+)
CAST/EiJ MGP_CASTEiJ_G0030315
protein coding gene Chr6:124451092-124461464 (+)
CBA/J MGP_CBAJ_G0030889
protein coding gene Chr6:133972384-133989804 (+)
DBA/2J MGP_DBA2J_G0031045
protein coding gene Chr6:119807194-119817891 (+)
FVB/NJ MGP_FVBNJ_G0030997
protein coding gene Chr6:118757476-118768686 (+)
LP/J MGP_LPJ_G0031125
protein coding gene Chr6:125798109-125810872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031032
protein coding gene Chr6:137940018-137951281 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031695
protein coding gene Chr6:124130398-124140908 (+)
PWK/PhJ MGP_PWKPhJ_G0030029
protein coding gene Chr6:118641580-118652122 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029856
protein coding gene Chr6:122253213-122266472 (+)
WSB/EiJ MGP_WSBEiJ_G0030397
protein coding gene Chr6:124432278-124443024 (+)



Homology
more
  • Human Ortholog
    AICDA, activation induced cytidine deaminase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AICDA, activation induced cytidine deaminase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AID, ARP2, CDA2, HEL-S-284, HIGM2
  • Links
    NCBI Gene ID: 57379
    neXtProt AC: NX_Q9GZX7
    UniProt: Q9GZX7

  • Chr Location
    12p13.31; chr12:8602166-8612970 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7623
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AICDA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human AICDA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 11 alleles in 10 genetic backgrounds
    24 phenotypes from multigenic genotypes
    185 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in elevated IgM levels and impairment of B cell class switching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11628 NCBI Gene Model | MGI Sequence Detail 10372 C57BL/6J ±  kb
    transcript NM_009645 RefSeq | MGI Sequence Detail 2413 Not Specified  
    polypeptide Q9WVE0 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 185
    • Earliest
      J:55852 Muramatsu M, et al., Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999 Jun 25;274(26):18470-6
    • Latest
      J:265925 Le Gallou S, et al., A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J Exp Med. 2018 Aug 6;215(8):2035-2053

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory