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Aicda
Gene Detail
Symbol

Name
ID
Aicda
activation-induced cytidine deaminase
MGI:1342279
Synonyms
Aid
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.65 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:122553801-122564180 bp, + strand
From VEGA annotation of GRCm38

  10380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AICDA
Gene Tree: Aicda

Human
homologs
AICDA, activation-induced cytidine deaminase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57379
neXtProt AC: NX_Q9GZX7

Human Synonyms: AID, ARP2, CDA2, HEL-S-284, HIGM2

Human Chr (Location): 12p13; chr12:8602166-8612888 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AICDA

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(15) Transgenic(2)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in elevated IgM levels and impairment of B cell class switching.
 
Interactions
Aicda interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cellular response to lipopolysaccharide, cytidine deamination, ...
Component cytoplasm, exosome (RNase complex), ...
Function catalytic activity, cytidine deaminase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (124)    Tissues (106)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 30
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN aicda    NEW 
Molecular
reagents
All nucleic(10) cDNA(6) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034572 (Evidence)
Ensembl Gene Model ENSMUSG00000040627 (Evidence)
Entrez Gene 11628 (Evidence)
UniGene 391503
DFCI TC1629441, TC1588536
DoTS DT.40174299
EC 3.5.4.38
Consensus CDS Project CCDS20497.1
International Mouse Phenotyping Consortium Status Aicda
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034572 VEGA Gene Model | MGI Sequence Detail 10380 C57BL/6J ±  kb
transcript OTTMUST00000087712 VEGA | MGI Sequence Detail 2405 Not Applicable 
polypeptide OTTMUSP00000047742 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016192 APOBEC/CMP deaminase, zinc-binding
InterPro IPR007904 APOBEC-like, C-terminal
InterPro IPR013158 APOBEC-like, N-terminal
InterPro IPR002125 CMP/dCMP deaminase, zinc-binding
InterPro IPR016193 Cytidine deaminase-like
Protein Ontology PR:000003864 activation-induced cytidine deaminase
References
(Earliest) J:55852 Muramatsu M, et al., Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999 Jun 25;274(26):18470-6
(Latest) J:222037 Laffleur B, et al., Self-Restrained B Cells Arise following Membrane IgE Expression. Cell Rep. 2015 Feb 12;
All references(190)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory