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Aicda Gene Detail
Summary
  • Symbol
    Aicda
  • Name
    activation-induced cytidine deaminase
  • Synonyms
    Aid
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342279
    NCBI Gene: 11628
  • Gene Overview
    MyGene.info: AICDA
Location & Maps
more
  • Sequence Map
    Chr6:122553801-122564180 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10380 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AICDA, activation-induced cytidine deaminase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AICDA, activation-induced cytidine deaminase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AID, ARP2, CDA2, HEL-S-284, HIGM2
  • Links
    NCBI Gene ID: 57379
    neXtProt AC: NX_Q9GZX7

  • Chr Location
    12p13; chr12:8602166-8612888 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7623
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AICDA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human AICDA associations

Human Disease Mouse Models
       Immunodeficiency with Hyper-Igm, Type 2; HIGM2   OMIM: 605258
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 9 alleles in 8 genetic backgrounds
    24 phenotypes from multigenic genotypes
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Targeted
    15
  • Transgenic
    2
  • Incidental Mutations
    APF
Homozygous mutation of this gene results in elevated IgM levels and impairment of B cell class switching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034572 VEGA Gene Model | MGI Sequence Detail 10380 C57BL/6J ±  kb
transcript OTTMUST00000087712 VEGA | MGI Sequence Detail 2405 Not Applicable  
polypeptide OTTMUSP00000047742 VEGA | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003864 activation-induced cytidine deaminase
  • EC
  • InterPro Domains
    IPR016192 APOBEC/CMP deaminase, zinc-binding
    IPR013158 APOBEC-like, N-terminal
    IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding
    IPR016193 Cytidine deaminase-like
Molecular
Reagents
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  • All nucleic 10
    cDNA 6
    Primer pair 2
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 196
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 139
  • Earliest
    J:55852 Muramatsu M, et al., Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999 Jun 25;274(26):18470-6
  • Latest
    J:229766 Montamat-Sicotte D, et al., HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol. 2015 Aug;45(8):2365-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory