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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Aicda
activation-induced cytidine deaminase
MGI:1342279
24 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Aicdatm1(cre)Mnz/\Aicda+
\Ightm3Mnz/\Igh+
\Myctm39Mnz/\Myc+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:145691
spontaneous chromosome breakage J:145691
\Aicdatm1(cre)Mnz/\Aicda+
\Ightm3Mnz/\Igh+
\Myctm37Mnz/\Myc+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:145691
spontaneous chromosome breakage J:145691
\Aicdatm1(cre)Mnz/\Aicda+
\Gt(ROSA)26Sortm2(sb11)Njen/\Gt(ROSA)26Sor+
\TgTn(sb-T2/Onc2)6070Njen/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J 		increased B cell derived lymphoma incidence J:153656
increased follicular lymphoma incidence J:153656
increased hemolymphoid system tumor incidence J:153656
increased leukemia incidence J:153656
increased medulloblastoma incidence J:153656
increased skin squamous cell carcinoma incidence J:153656
increased T cell derived lymphoma incidence J:153656
increased tumor incidence J:153656
premature death J:153656
\Aicdatm1Hon/\Aicdatm1Hon
\Bcl6tm1.1Jwan/\Bcl6tm1.1Jwan
involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj 		abnormal somatic hypermutation frequency J:190534
\Aicdatm1Hon/\Aicdatm1Hon
\Blmtm3Brd/\Blmtm3Brd
\Ightm4.1Mnz/\Igh+
\Trp53bp1tm1Jc/\Trp53bp1tm1Jc
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		normal immune system phenotype J:194603
\Aicdatm1Hon/\Aicdatm1Hon
\Exo1tm1Wed/\Exo1tm1Wed
\Ightm4.1Mnz/\Igh+
involves: C57BL/6 * CBA/JNCrlj * SJL 		abnormal immunoglobulin heavy chain V(D)J recombination J:194603
\Aicdatm1Hon/\Aicdatm1Hon
\Exo1tm1Wed/\Exo1tm1Wed
\Ightm4.1Mnz/\Igh+
\Trp53bp1tm1Jc/\Trp53bp1tm1Jc
involves: 129 * C57BL/6 * CBA/JNCrlj * SJL 		abnormal immunoglobulin heavy chain V(D)J recombination J:194603
\Aicdatm1Hon/\Aicdatm1Hon
\Ightm3Mnz/\Igh+
\Myctm37Mnz/\Myc+
involves: C57BL/6 * CBA 		induced chromosome breakage J:145691
\Aicdatm1Hon/\Aicdatm1Hon
\Ightm3Mnz/\Ightm4.1Mnz
\Trp53bp1tm1Jc/\Trp53bp1tm1Jc
involves: 129 * C57BL/6 * CBA 		abnormal class switch recombination J:159173
\Aicdatm1Hon/\Aicdatm1Hon
\Ightm4.1Mnz/\Igh+
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		abnormal immunoglobulin heavy chain V(D)J recombination J:194603
\Aicdatm1Hon/\Aicdatm1Hon
\Ightm4.1Mnz/\Igh+
\Trp53bp1tm1Jc/\Trp53bp1tm1Jc
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		abnormal immunoglobulin heavy chain V(D)J recombination J:194603
\Aicdatm1Hon/\Aicdatm1Hon
\Ighmtm1.1(IGH-2)Cog/\Ighm+
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N 		abnormal B cell physiology J:157575
\Aicdatm1Hon/\Aicdatm1Hon
\Tg(Cr2-cre)3Cgn/?
\Xrcc4tm1Fwa/\Xrcc4tm2Fwa
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA 		spontaneous chromosome breakage J:150339
\Aicdatm1Hon/\Aicdatm1Hon
\Tg(Igkv3-5*-MYC)#Plbe/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		normal immune system phenotype J:131912
\Bcl2l11tm1Ast/\Bcl2l11tm1Ast
\Dicer1tm1Bdh/\Dicer1tm1Bdh
\Aicdatm1(cre)Njen/\Aicda+
involves: 129S1/Sv * C57BL/6 		abnormal B cell differentiation J:181782
decreased germinal center B cell number J:181782
decreased plasma cell number J:181782
\Dicer1tm1Bdh/\Dicer1tm1Bdh
\Aicdatm1(cre)Njen/\Aicda+
involves: 129 * C57BL/6 		abnormal germinal center B cell physiology J:181782
abnormal humoral immune response J:181782
absent memory B cells J:181782
absent plasma cells J:181782
decreased germinal center B cell number J:181782
decreased immunoglobulin level J:181782
normal immune system phenotype J:181782
\Ightm1Mnz/\Ightm1Mnz
\Dis3tm1.1Uba/\Dis3tm1.1Uba
\Aicdatm1(cre)Uba/\Aicda+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal somatic hypermutation frequency J:302856
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory