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Hey2
Gene Detail
Symbol

Name
ID
Hey2
hairy/enhancer-of-split related with YRPW motif 2
MGI:1341884
Synonyms
bHLHb32, CHF1, Herp1, Hesr2, Hrt2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
17.19 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:30832359-30842801 bp, - strand
From VEGA annotation of GRCm38

  10443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HEY2
Gene Tree: Hey2

Human
homologs
HEY2, hes-related family bHLH transcription factor with YRPW motif 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23493
neXtProt AC: NX_Q9UBP5

Human Synonyms: bHLHb32, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2

Human Chr (Location): 6q21; chr6:125749586-125761271 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit cardiac hypertrophy, ventricular septal defects, pulmonary and liver congestion, and reduced preweaning viability.
 
Human Diseases Modeled in Mice Using Hey2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Hey2 interacts with 261 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process anterior/posterior axis specification, arterial endothelial cell differentiation, ...
Component cytoplasm, nucleus, ...
Function DNA binding, histone deacetylase binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (119 records)
Data Summary: Results (393)    Tissues (240)    Images (86)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 333
In situ reporter (knock in) 14
Northern blot 37
RT-PCR 9
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA HEY2 ; Xenbase hey2 ; ZFIN hey2    NEW 
Molecular
reagents
All nucleic(34) cDNA(26) Primer pair(4) Other(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000038103 (Evidence)
Ensembl Gene Model ENSMUSG00000019789 (Evidence)
Entrez Gene 15214 (Evidence)
UniGene 103573
DFCI TC1582759
DoTS DT.483903
NIA Mouse Gene Index U031654
Consensus CDS Project CCDS23766.1
International Mouse Phenotyping Consortium Status Hey2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038103 VEGA Gene Model | MGI Sequence Detail 10443 C57BL/6J ±  kb
transcript OTTMUST00000098167 VEGA | MGI Sequence Detail 2550 Not Applicable 
polypeptide OTTMUSP00000055117 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008529 hairy/enhancer-of-split related with YRPW motif protein 2
References
(Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9
All references(174)
Disease annotation references (1)
Other
accession IDs
MGI:1353481

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory