Hey2
Gene Detail

Symbol Name ID

Hey2 hairy/enhancer-of-split related with YRPW motif 2 MGI:1341884

Synonyms

bHLHb32, CHF1, Herp1, Hesr2, Hrt2

Feature Type

protein coding gene

Genetic Map

Chromosome 10

17.19 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:30832359-30842801 bp, - strand From VEGA annotation of GRCm38   10443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hey2

Human homologs

Human Homolog		HEY2, hairy/enhancer-of-split related with YRPW motif 2
NCBI Gene ID		23493
neXtProt AC		NX_Q9UBP5
Human Synonyms		bHLHb32, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2
Human Chr (Location)		6q21; chr6:126070732-126082415 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygotes for targeted null mutations exhibit cardiac hypertrophy, ventricular septal defects, pulmonary and liver congestion, and reduced preweaning viability.

 
Human Diseases Modeled Using Mouse Hey2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (93 annotations)

Process	anterior/posterior axis specification, arterial endothelial cell differentiation, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, histone deacetylase binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (94 records)
Data Summary: Results (270)    Tissues (148)    Images (59)
Theiler Stages: 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	239
Northern blot	29
RT-PCR	2

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) cDNA(23) Primer pair(2) Other(4)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000038103 (Evidence)
Ensembl Gene Model	ENSMUSG00000019789 (Evidence)
Entrez Gene	15214 (Evidence)
UniGene	103573
DFCI	TC1582759
DoTS	DT.483903
NIA Mouse Gene Index	U031654
Consensus CDS Project	CCDS23766.1
International Mouse Knockout Project Status	Hey2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038103	VEGA Gene Model | MGI Sequence Detail	10443	C57BL/6J
transcript	OTTMUST00000098167	VEGA | MGI Sequence Detail	2550	Not Applicable
polypeptide	OTTMUSP00000055117	VEGA | MGI Sequence Detail	339	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR003650	Orange
InterPro	IPR018352	Orange subgroup
Protein Ontology	PR:000008529	hairy/enhancer-of-split related with YRPW motif protein 2

References

(Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:190179 Xing Y, et al., NOTCH1 is required for regeneration of Clara cells during repair of airway injury. Stem Cells. 2012 May;30(5):946-55
All references(147)

Other accession IDs

MGI:1353481