About   Help   FAQ
Hey2 Gene Detail
Summary
  • Symbol
    Hey2
  • Name
    hairy/enhancer-of-split related with YRPW motif 2
  • Synonyms
    bHLHb32, CHF1, Herp1, Hesr2, Hrt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341884
    NCBI Gene: 15214
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr76 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr10:30708355-30718779 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 17.19 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341884
 protein coding gene Chr10:30708355-30718797 (-)
129S1/SvImJ ENSMUSG00200009039
 protein coding gene Chr10:27554927-27565366 (-)
A/J ENSMUSG00195013872
 protein coding gene Chr10:27826914-27837356 (-)
AKR/J ENSMUSG00220010511
 protein coding gene Chr10:27519565-27530003 (-)
BALB/cJ ENSMUSG00180017368
 protein coding gene Chr10:27951390-27961831 (-)
C3H/HeJ ENSMUSG00175024729
 protein coding gene Chr10:27709647-27720089 (-)
C57BL/6NJ ENSMUSG00215012551
 protein coding gene Chr10:27500556-27510998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015215
 protein coding gene Chr10:26625733-26636236 (-)
CAST/EiJ ENSTCUG00005013507
 protein coding gene Chr10:27327658-27338109 (-)
CBA/J ENSMUSG00210023343
 protein coding gene Chr10:27633917-27644357 (-)
DBA/2J ENSMUSG00185006956
 protein coding gene Chr10:27786667-27797107 (-)
FVB/NJ ENSMUSG00205009121
 protein coding gene Chr10:27785090-27795532 (-)
JF1/MsJ ENSUMUG00000012474
 protein coding gene Chr10:27591781-27602208 (-)
LP/J ENSMUSG00230011202
 protein coding gene Chr10:29555610-29566052 (-)
NOD/ShiLtJ ENSMUSG00190014835
 protein coding gene Chr10:27898333-27908774 (-)
NZO/HlLtJ ENSMUSG00225033445
 protein coding gene Chr10:33813930-33824370 (-)
PWK/PhJ ENSLUMG00010009398
 protein coding gene Chr10:27423998-27434408 (-)
SPRET/EiJ ENSMSPG00010014685
 protein coding gene Chr10:28449505-28459950 (-)
WSB/EiJ ENSIUOG00005030488
 protein coding gene Chr10:27275627-27286069 (-)



Homology
more
  • Human Ortholog
    HEY2, hes related family bHLH transcription factor with YRPW motif 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HEY2, hes related family bHLH transcription factor with YRPW motif 2
  • Synonyms
    bHLHb32, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2
  • Links
    NCBI Gene ID: 23493
    UniProt: Q9UBP5

  • Chr Location
    6q22.31; chr6:125747664-125761269 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Hey2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 7 alleles in 14 genetic backgrounds
    37 phenotypes from multigenic genotypes
    4 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac hypertrophy, ventricular septal defects, pulmonary and liver congestion, and reduced preweaning viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    141
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1277
  • Tissues
    367
  • cDNA Data
    30
  • Literature Summary
    221
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15214 NCBI Gene Model | MGI Sequence Detail 10425 C57BL/6J ±  kb
    transcript NM_013904 RefSeq | MGI Sequence Detail 2549 Not Specified  
    polypeptide Q9QUS4 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008529 hairy/enhancer-of-split related with YRPW motif protein 2
      (term hierarchy)
    • InterPro Domains
      IPR050370 Hairy and Enhancer of Split/HEY-related
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR003650 Orange domain
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 30
      Primer pair 27
      Other 20
      Antibodies 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1353481
    References
    more
    • Summaries
      All 313
      Developmental Gene Expression 221
      Diseases 2
      Gene Ontology 35
      Phenotypes 49
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:380984 Zhang Y, et al., ZBTB20 coordinates the proliferation-differentiation switch of incisor epithelial progenitor cells. Development. 2026 Feb 15;153(4):dev205250
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory