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Hey2 Gene Detail
Summary
  • Symbol
    Hey2
  • Name
    hairy/enhancer-of-split related with YRPW motif 2
  • Synonyms
    bHLHb32, CHF1, Herp1, Hesr2, Hrt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341884
    NCBI Gene: 15214
  • Gene Overview
    MyGene.info: HEY2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:30832359-30842801 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10443 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 17.19 cM, cytoband A4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HEY2, hes related family bHLH transcription factor with YRPW motif 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HEY2, hes related family bHLH transcription factor with YRPW motif 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHb32, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2
  • Links
    NCBI Gene ID: 23493
    neXtProt AC: NX_Q9UBP5
    UniProt: Q9UBP5

  • Chr Location
    6q22.31; chr6:125747592-125762243 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22705
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HEY2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Hey2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 7 alleles in 14 genetic backgrounds
    34 phenotypes from multigenic genotypes
    4 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac hypertrophy, ventricular septal defects, pulmonary and liver congestion, and reduced preweaning viability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038103 VEGA Gene Model | MGI Sequence Detail 10443 C57BL/6J ±  kb
    transcript OTTMUST00000098167 VEGA | MGI Sequence Detail 2550 Not Applicable  
    polypeptide OTTMUSP00000055117 VEGA | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      59 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008529 hairy/enhancer-of-split related with YRPW motif protein 2
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR003650 Orange domain
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 27
      Primer pair 7
      Other 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1353481
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 145
      Diseases 2
      Gene Ontology 31
      Phenotypes 39
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262042 Del Monte-Nieto G, et al., Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory