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Sequence Detail
Q9QUS4 Q3TZ99 Q8CD44 (UniProt | EBI) Last sequence update: 2000-05-01
Last annotation update: 2023-11-08
from provider
RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein 2;AltName: Full=HES-related repressor protein 2;AltName: Full=Hairy and enhancer of split-related protein 2; Short=HESR-2;AltName: Full=Hairy-related transcription factor 2;
Polypeptide 339 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Hey2 hairy/enhancer-of-split related with YRPW motif 2 110 152 3 15
Sequence references in MGI J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
J:58781 Nakagawa O, et al., HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol. 1999 Dec 1;216(1):72-84
J:60859 Chin MT, et al., Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. J Biol Chem. 2000 Mar 3;275(9):6381-7
J:62860 Steidl C, et al., Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Genomics. 2000 Jun 1;66(2):195-203
J:64398 Maier MM, et al., Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Biochem Biophys Res Commun. 2000 Aug 28;275(2):652-60
J:70797 Iso T, et al., HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol. 2001 Sep;21(17):6071-9
J:74742 Iso T, et al., HERP1 is a cell type-specific primary target of Notch. J Biol Chem. 2002 Feb 22;277(8):6598-607
J:79024 Gessler M, et al., Mouse gridlock. No Aortic Coarctation or Deficiency, but Fatal Cardiac Defects in Hey2 -/- Mice. Curr Biol. 2002 Sep 17;12(18):1601
J:79025 Donovan J, et al., Tetralogy of fallot and other congenital heart defects in hey2 mutant mice. Curr Biol. 2002 Sep 17;12(18):1605
J:80681 Sakata Y, et al., Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16197-202
J:86573 Sakamoto M, et al., The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem. 2003 Nov 7;278(45):44808-15
J:89444 Fischer A, et al., The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11
J:96337 Kokubo H, et al., Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15;278(2):301-9
J:97120 Kokubo H, et al., Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 3;95(5):540-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101349 Fischer A, et al., Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005 Oct;25(20):8960-70
J:103925 Sakata Y, et al., Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2069-74
J:109366 Satow T, et al., The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. J Neurosci. 2001 Feb 15;21(4):1265-73
J:119923 Kokubo H, et al., Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development. 2007 Feb;134(4):747-55
J:121581 Nakagawa O, et al., Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13655-60
J:133699 Fischer A, et al., Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63
J:133798 Koibuchi N, et al., CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression. Circ Res. 2007 Mar 30;100(6):850-5
J:175112 Iso T, et al., HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol. 2001 Sep;21(17):6080-9
J:175191 Kathiriya IS, et al., Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem. 2004 Dec 24;279(52):54937-43

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory