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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hey2
hairy/enhancer-of-split related with YRPW motif 2
MGI:1341884
79 phenotypes from 7 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hey2tm1Eno/Hey2tm2Eno
Tg(Nkx2-5-cre)9Eno/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal heart left ventricle morphology J:121577
abnormal heart ventricle morphology J:121577
abnormal interventricular septum morphology J:121577
normal cardiovascular system phenotype J:121577
decreased cardiac muscle contractility J:121577
dilated heart right ventricle J:121577
enlarged heart J:121577
Hey2tm1Eno/Hey2tm2Eno
Tg(Tagln-cre)1Her/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		decreased cardiac muscle contractility J:121577
dilated heart right ventricle J:121577
perinatal lethality, incomplete penetrance J:121577
ventricular septal defect J:121577
Hey2tm1Eno/Hey2tm2Eno
Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		normal cardiovascular system phenotype J:121577
normal mortality/aging J:121577
Hey2tm1Gess/Hey2tm1Gess
B6.129P2-Hey2tm1Gess 		abnormal cardiovascular system morphology J:93980
abnormal heart shape J:93980
patent cardiac foramen ovale J:93980
perimembraneous ventricular septal defect J:93980
postnatal lethality, incomplete penetrance J:93980
tricuspid valve atresia J:93980
tricuspid valve stenosis J:93980
Hey2tm1Gess/Hey2tm1Gess
involves: 129P2/OlaHsd 		abnormal cardiac epithelial to mesenchymal transition J:133699
perimembraneous ventricular septal defect J:133699
Hey2tm1Gess/Hey2tm1Gess
involves: 129P2/OlaHsd * C57BL/6 		atrial septal defect J:79024
cardiac fibrosis J:79024
heart left ventricle hypertrophy J:79024
heart right ventricle hypertrophy J:79024
increased heart weight J:79024
myocardial fiber disarray J:79024
postnatal growth retardation J:79024
postnatal lethality, incomplete penetrance J:79024
ventricular septal defect J:79024
Hey2tm1Gess/Hey2tm1Gess
involves: 129P2/OlaHsd * CD-1 		postnatal lethality, incomplete penetrance J:93980
ventricular septal defect J:93980
Hey2tm1Kkb/Hey2tm1Kkb
involves: 129S7/SvEvBrd * C57BL/6 		abnormal aortic valve cusp morphology J:97120
abnormal atrioventricular valve morphology J:97120
abnormal endocardium morphology J:97120
abnormal mitral valve morphology J:97120
abnormal myocardial fiber morphology J:97120, J:216895
abnormal myocardium layer morphology J:216895
abnormal pulmonary alveolus morphology J:97120
abnormal pulmonary valve cusp morphology J:97120
abnormal semilunar valve morphology J:97120, J:216895
abnormal tricuspid valve morphology J:97120
abnormal ventricle myocardium morphology J:216895
abnormal Z line morphology J:216895
aortic valve regurgitation J:216895
aortic valve stenosis J:216895
atrioventricular valve regurgitation J:97120
cardiac fibrosis J:216895
congestive heart failure J:97120
decreased heart left ventricle muscle contractility J:97120, J:216895
decreased heart rate J:97120
dilated heart atrium J:97120
dilated heart left ventricle J:97120, J:216895
dilated heart right ventricle J:97120
enlarged heart J:97120
increased heart weight J:97120
increased lung weight J:97120
liver vascular congestion J:97120
mitral valve regurgitation J:97120
ostium secundum atrial septal defect J:97120
perimembraneous ventricular septal defect J:97120
postnatal growth retardation J:97120
postnatal lethality, complete penetrance J:97120
premature death J:216895
pulmonary edema J:97120
pulmonary vascular congestion J:97120
respiratory distress J:97120
thick aortic valve J:216895
thick pulmonary valve J:216895
thick semilunar valve J:216895
tricuspid valve regurgitation J:97120
tricuspid valve stenosis J:97120
Hey2tm1Mtc/Hey2tm1Mtc
B6.Cg-Hey2tm1Mtc 		abnormal atrioventricular valve morphology J:105823
abnormal blood vessel morphology J:105823
abnormal heart ventricle morphology J:105823
abnormal mitral valve morphology J:105823
abnormal pulmonary artery morphology J:105823
abnormal tricuspid valve morphology J:105823
decreased aorta wall thickness J:105823
dilated heart left ventricle J:105823
lethality at weaning, incomplete penetrance J:105823
thick mitral valve cusps J:105823
thin ventricular wall J:105823
ventricular septal defect J:105823
Hey2tm1Mtc/Hey2tm1Mtc
C.Cg-Hey2tm1Mtc 		abnormal atrioventricular valve morphology J:105823
abnormal heart septum morphology J:105823
abnormal mitral valve morphology J:105823
lethality at weaning, incomplete penetrance J:105823
tricuspid valve atresia J:105823
tricuspid valve stenosis J:105823
ventricular septal defect J:105823
Hey2tm1Mtc/Hey2tm1Mtc
involves: 129X1/SvJ 		absent interventricular septum membranous part J:80681
normal cardiovascular system phenotype J:80681
liver vascular congestion J:80681
perimembraneous ventricular septal defect J:80681
postnatal growth retardation J:80681
postnatal lethality, complete penetrance J:80681
pulmonary vascular congestion J:80681
visceral vascular congestion J:80681
Hey2tm1Mtc/Hey2tm1Mtc
involves: 129X1/SvJ * C57BL/6 		absent interventricular septum membranous part J:80681
cardiac interstitial fibrosis J:80681
cardiomyopathy J:80681
decreased body size J:80681
decreased cardiac muscle contractility J:80681
liver vascular congestion J:80681
perimembraneous ventricular septal defect J:80681
postnatal growth retardation J:80681
postnatal lethality, incomplete penetrance J:80681
pulmonary vascular congestion J:80681
visceral vascular congestion J:80681
Hey2tm1Uts/Hey2tm1Uts
either: (involves: 129X1/SvJ) or (involves: C57BL/6) 		abnormal heart development J:79025
abnormal heart shape J:79025
abnormal pulmonary valve cusp morphology J:79025
atrial septal defect J:79025
enlarged heart J:79025
heart left ventricle hypertrophy J:79025
heart right ventricle hypertrophy J:79025
muscular ventricular septal defect J:79025
overriding aortic valve J:79025
perimembraneous ventricular septal defect J:79025
postnatal lethality, incomplete penetrance J:79025
pulmonary artery stenosis J:79025
pulmonary valve stenosis J:79025
tricuspid valve atresia J:79025
Hey2tm2.1Mtc/Hey2tm2.1Mtc
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6 * FVB/N * SJL 		abnormal myocardial fiber physiology J:186570
cardiac fibrosis J:186570
cardiac hypertrophy J:186570
congestive heart failure J:186570
decreased cardiac muscle contractility J:186570
increased response of heart to induced stress J:186570
Hey2tm2Eno/Hey2tm2Eno
129-Hey2tm2Eno 		neonatal lethality, complete penetrance J:121577
ventricular septal defect J:121577
Hey2tm2Eno/Hey2tm2Eno
involves: 129S6/SvEvTac * C57BL/6 		neonatal lethality, complete penetrance J:121577
ventricular septal defect J:121577
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory