78 phenotypes from 7 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hey2tm1Eno/Hey2tm2Eno Tg(Nkx2-5-cre)9Eno/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal heart left ventricle morphology	J:121577
	abnormal heart ventricle morphology	J:121577
	abnormal interventricular septum morphology	J:121577
	normal cardiovascular system phenotype	J:121577
	decreased cardiac muscle contractility	J:121577
	dilated heart right ventricle	J:121577
	enlarged heart	J:121577
Hey2tm1Eno/Hey2tm2Eno Tg(Tagln-cre)1Her/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	decreased cardiac muscle contractility	J:121577
	dilated heart right ventricle	J:121577
	perinatal lethality, incomplete penetrance	J:121577
	ventricular septal defect	J:121577
Hey2tm1Eno/Hey2tm2Eno Tg(Tek-cre)1Ywa/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	normal cardiovascular system phenotype	J:121577
	normal mortality/aging	J:121577
Hey2tm1Gess/Hey2tm1Gess B6.129P2-Hey2tm1Gess	abnormal cardiovascular system morphology	J:93980
	abnormal heart shape	J:93980
	patent cardiac foramen ovale	J:93980
	perimembraneous ventricular septal defect	J:93980
	postnatal lethality, incomplete penetrance	J:93980
	tricuspid valve atresia	J:93980
	tricuspid valve stenosis	J:93980
Hey2tm1Gess/Hey2tm1Gess involves: 129P2/OlaHsd	abnormal cardiac epithelial to mesenchymal transition	J:133699
	perimembraneous ventricular septal defect	J:133699
Hey2tm1Gess/Hey2tm1Gess involves: 129P2/OlaHsd * C57BL/6	atrial septal defect	J:79024
	cardiac fibrosis	J:79024
	heart left ventricle hypertrophy	J:79024
	heart right ventricle hypertrophy	J:79024
	increased heart weight	J:79024
	myocardial fiber disarray	J:79024
	postnatal growth retardation	J:79024
	postnatal lethality, incomplete penetrance	J:79024
	ventricular septal defect	J:79024
Hey2tm1Gess/Hey2tm1Gess involves: 129P2/OlaHsd * CD-1	postnatal lethality, incomplete penetrance	J:93980
	ventricular septal defect	J:93980
Hey2tm1Kkb/Hey2tm1Kkb involves: 129S7/SvEvBrd * C57BL/6	abnormal aortic valve cusp morphology	J:97120
	abnormal atrioventricular valve morphology	J:97120
	abnormal endocardium morphology	J:97120
	abnormal mitral valve morphology	J:97120
	abnormal myocardial fiber morphology	J:97120, J:216895
	abnormal myocardium layer morphology	J:216895
	abnormal pulmonary alveolus morphology	J:97120
	abnormal pulmonary valve cusp morphology	J:97120
	abnormal semilunar valve morphology	J:97120, J:216895
	abnormal tricuspid valve morphology	J:97120
	abnormal ventricle myocardium morphology	J:216895
	abnormal Z line morphology	J:216895
	aortic valve regurgitation	J:216895
	aortic valve stenosis	J:216895
	atrioventricular valve regurgitation	J:97120
	cardiac fibrosis	J:216895
	congestive heart failure	J:97120
	decreased heart rate	J:97120
	decreased ventricle muscle contractility	J:97120, J:216895
	dilated heart atrium	J:97120
	dilated heart left ventricle	J:97120, J:216895
	dilated heart right ventricle	J:97120
	enlarged heart	J:97120
	increased heart weight	J:97120
	increased lung weight	J:97120
	liver vascular congestion	J:97120
	mitral valve regurgitation	J:97120
	ostium secundum atrial septal defect	J:97120
	perimembraneous ventricular septal defect	J:97120
	postnatal growth retardation	J:97120
	postnatal lethality, complete penetrance	J:97120
	premature death	J:216895
	pulmonary edema	J:97120
	pulmonary vascular congestion	J:97120
	respiratory distress	J:97120
	thick aortic valve	J:216895
	thick pulmonary valve	J:216895
	tricuspid valve regurgitation	J:97120
	tricuspid valve stenosis	J:97120
Hey2tm1Mtc/Hey2tm1Mtc B6.Cg-Hey2tm1Mtc	abnormal atrioventricular valve morphology	J:105823
	abnormal blood vessel morphology	J:105823
	abnormal heart ventricle morphology	J:105823
	abnormal pulmonary artery morphology	J:105823
	abnormal tricuspid valve morphology	J:105823
	decreased aorta wall thickness	J:105823
	dilated heart left ventricle	J:105823
	lethality at weaning, incomplete penetrance	J:105823
	thick mitral valve cusps	J:105823
	thin ventricular wall	J:105823
	ventricular septal defect	J:105823
Hey2tm1Mtc/Hey2tm1Mtc C.Cg-Hey2tm1Mtc	abnormal atrioventricular valve morphology	J:105823
	abnormal heart septum morphology	J:105823
	abnormal mitral valve morphology	J:105823
	lethality at weaning, incomplete penetrance	J:105823
	tricuspid valve atresia	J:105823
	tricuspid valve stenosis	J:105823
	ventricular septal defect	J:105823
Hey2tm1Mtc/Hey2tm1Mtc involves: 129X1/SvJ	absent interventricular septum membranous part	J:80681
	normal cardiovascular system phenotype	J:80681
	liver vascular congestion	J:80681
	perimembraneous ventricular septal defect	J:80681
	postnatal growth retardation	J:80681
	postnatal lethality, complete penetrance	J:80681
	pulmonary vascular congestion	J:80681
	visceral vascular congestion	J:80681
Hey2tm1Mtc/Hey2tm1Mtc involves: 129X1/SvJ * C57BL/6	absent interventricular septum membranous part	J:80681
	cardiac interstitial fibrosis	J:80681
	cardiomyopathy	J:80681
	decreased body size	J:80681
	decreased cardiac muscle contractility	J:80681
	liver vascular congestion	J:80681
	perimembraneous ventricular septal defect	J:80681
	postnatal growth retardation	J:80681
	postnatal lethality, incomplete penetrance	J:80681
	pulmonary vascular congestion	J:80681
	visceral vascular congestion	J:80681
Hey2tm1Uts/Hey2tm1Uts either: (involves: 129X1/SvJ) or (involves: C57BL/6)	abnormal heart development	J:79025
	abnormal heart shape	J:79025
	abnormal pulmonary valve cusp morphology	J:79025
	atrial septal defect	J:79025
	enlarged heart	J:79025
	heart left ventricle hypertrophy	J:79025
	heart right ventricle hypertrophy	J:79025
	muscular ventricular septal defect	J:79025
	overriding aortic valve	J:79025
	perimembraneous ventricular septal defect	J:79025
	postnatal lethality, incomplete penetrance	J:79025
	pulmonary artery stenosis	J:79025
	pulmonary valve stenosis	J:79025
	tricuspid valve atresia	J:79025
Hey2tm2.1Mtc/Hey2tm2.1Mtc Tg(Myh6-cre)2182Mds/0 involves: C57BL/6 * FVB/N * SJL	abnormal myocardial fiber physiology	J:186570
	cardiac fibrosis	J:186570
	cardiac hypertrophy	J:186570
	congestive heart failure	J:186570
	decreased cardiac muscle contractility	J:186570
	increased response of heart to induced stress	J:186570
Hey2tm2Eno/Hey2tm2Eno 129-Hey2tm2Eno	neonatal lethality, complete penetrance	J:121577
	ventricular septal defect	J:121577
Hey2tm2Eno/Hey2tm2Eno involves: 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:121577
	ventricular septal defect	J:121577