Rb1cc1
Gene Detail

Symbol

Name
ID

Rb1cc1
RB1-inducible coiled-coil 1
MGI:1341850

Synonyms

2900055E04Rik, 5930404L04Rik, Cc1, Fip200, LaXp180, mKIAA0203

Feature Type

protein coding gene

Genetic Map

Chromosome 1
1.89 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:6206197-6276648 bp, + strand From VEGA annotation of GRCm38   70452 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Rb1cc1

Human
homologs

Human Homolog		RB1CC1, RB1-inducible coiled-coil 1
NCBI Gene ID		9821
neXtProt AC		NX_Q8TDY2
Human Synonyms		ATG17, CC1, FIP200, PPP1R131
Human Chr (Location)		8q11; chr8:52622458-52714466 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human RB1CC1

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutation of this gene results in embryonic lethality at mid/late gestation associated with heart failure and liver degeneration.

 
Phenotype Images(2)

Interactions

Rb1cc1 interacts with 386 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (27 annotations)

Process	autophagic vacuole assembly, autophagy, ...
Component	ATG1/UKL1 signaling complex, cytoplasm, ...
Function	protein binding, protein kinase binding

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (48)    Tissues (30)    Images (12)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	11
RNA in situ	22
Northern blot	15

cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) cDNA(18)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000033467 (Evidence)
Ensembl Gene Model	ENSMUSG00000025907 (Evidence)
Entrez Gene	12421 (Evidence)
NIA Mouse Gene Index	U000013
Consensus CDS Project	CCDS35507.1
International Mouse Knockout Project Status	Rb1cc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033467	VEGA Gene Model | MGI Sequence Detail	70452	C57BL/6J
transcript	OTTMUST00000084091	VEGA | MGI Sequence Detail	7607	Not Applicable
polypeptide	OTTMUSP00000045266	VEGA | MGI Sequence Detail	1588	Not Applicable

All sequences(98) RefSeq(14) UniProt(12)

Polymorphisms

SNPs within 2kb(507 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR019460	Autophagy-related protein 11
Protein Ontology	PR:000013774	RB1-inducible coiled-coil protein 1

References

(Earliest) J:51752 Maucuer A, et al., Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3100-4
(Latest) J:213671 Uemura T, et al., A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane. Mol Cell Biol. 2014 May;34(9):1695-706
All references(63)

Other
accession IDs

MGI:1920276, MGI:1924359