About   Help   FAQ
Rb1cc1
Gene Detail
Symbol

Name
ID
Rb1cc1
RB1-inducible coiled-coil 1
MGI:1341850
Synonyms
2900055E04Rik, 5930404L04Rik, Cc1, Fip200, LaXp180, mKIAA0203
Feature Type
protein coding gene
Genetic Map
Chromosome 1
1.89 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:6206197-6276648 bp, + strand
From VEGA annotation of GRCm38

  70452 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Rb1cc1

Human
homologs
Human Homolog RB1CC1, RB1-inducible coiled-coil 1
NCBI Gene ID 9821
neXtProt AC  NX_Q8TDY2
Human Synonyms  ATG17, CC1, FIP200, PPP1R131
Human Chr (Location)  8q11; chr8:52622458-52714466 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RB1CC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality at mid/late gestation associated with heart failure and liver degeneration.
 
Phenotype Images(2)
Interactions
Rb1cc1 interacts with 386 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component ATG1/UKL1 signaling complex, cytoplasm, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (48)    Tissues (30)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 22
Northern blot 15
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033467 (Evidence)
Ensembl Gene ModelENSMUSG00000025907 (Evidence)
Entrez Gene12421 (Evidence)
NIA Mouse Gene IndexU000013
Consensus CDS ProjectCCDS35507.1
International Mouse Knockout Project StatusRb1cc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033467 VEGA Gene Model | MGI Sequence Detail 70452 C57BL/6J ±  kb
transcript OTTMUST00000084091 VEGA | MGI Sequence Detail 7607 Not Applicable 
polypeptide OTTMUSP00000045266 VEGA | MGI Sequence Detail 1588 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(6) UniProt(23)
Polymorphisms
SNPs within 2kb(507 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019460 Autophagy-related protein 11
Protein Ontology PR:000013774 RB1-inducible coiled-coil protein 1
References
(Earliest) J:51752 Maucuer A, et al., Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3100-4
(Latest) J:213671 Uemura T, et al., A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane. Mol Cell Biol. 2014 May;34(9):1695-706
All references(63)
Other
accession IDs
MGI:1920276, MGI:1924359

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/23/2014
MGI 5.20
The Jackson Laboratory