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P2rx6
Gene Detail
Symbol

Name
ID
P2rx6
purinergic receptor P2X, ligand-gated ion channel, 6
MGI:1337113
Synonyms
P2rxl1, P2xm
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:17561885-17577800 bp, + strand
From VEGA annotation of GRCm38

  15916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3975  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: P2RX6
Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx6

Human
homologs
P2RX6, purinergic receptor P2X, ligand gated ion channel, 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9127
neXtProt AC: NX_O15547

Human Synonyms: P2RXL1, P2X6, P2XM

Human Chr (Location): 22q11.21; chr22:21014451-21028013 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit a significant increase in thermal response latency during hot plate testing, and are resistant to metrazol-induced seizures.
 
Interactions
P2rx6 interacts with 279 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cation transmembrane transport, cation transport, ...
Component cell junction, cytoplasm, ...
Function ATP binding, extracellular ATP-gated cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035232 (Evidence)
Ensembl Gene Model ENSMUSG00000022758 (Evidence)
Entrez Gene 18440 (Evidence)
UniGene 8032
DFCI TC1676435, TC1641263, TC1591462
DoTS DT.91572982, DT.99849355
NIA Mouse Gene Index U016875
Consensus CDS Project CCDS28007.2, CCDS49778.1
International Mouse Phenotyping Consortium Status P2rx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035232 VEGA Gene Model | MGI Sequence Detail 15916 C57BL/6J ±  kb
transcript OTTMUST00000089807 VEGA | MGI Sequence Detail 2345 Not Applicable 
polypeptide OTTMUSP00000049114 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003049 P2X6 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012193 P2X purinoceptor 6
References
(Earliest) J:51784 Nawa G, et al., Cloning and characterization of the murine P2XM receptor gene. J Hum Genet. 1998;43(4):262-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory