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P2rx6 Gene Detail
Summary
  • Symbol
    P2rx6
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 6
  • Synonyms
    P2rxl1, P2xm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337113
    NCBI Gene: 18440
  • Gene Overview
    MyGene.info: P2RX6
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17561855-17572012 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337113
protein coding gene Chr16:17561855-17577800 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022585
protein coding gene Chr16:14720364-14736277 (+)
A/J MGP_AJ_G0022546
protein coding gene Chr16:13991411-14007323 (+)
AKR/J MGP_AKRJ_G0022523
protein coding gene Chr16:14537540-14553455 (+)
BALB/cJ MGP_BALBcJ_G0022549
protein coding gene Chr16:14143936-14159849 (+)
C3H/HeJ MGP_C3HHeJ_G0022316
protein coding gene Chr16:14689918-14705831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023000
protein coding gene Chr16:14956843-14972758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020520
protein coding gene Chr16:14059536-14075576 (+)
CAST/EiJ MGP_CASTEiJ_G0021844
protein coding gene Chr16:14590494-14606791 (+)
CBA/J MGP_CBAJ_G0022287
protein coding gene Chr16:15627359-15643272 (+)
DBA/2J MGP_DBA2J_G0022417
protein coding gene Chr16:13909449-13925362 (+)
FVB/NJ MGP_FVBNJ_G0022393
protein coding gene Chr16:13951040-13966947 (+)
LP/J MGP_LPJ_G0022484
protein coding gene Chr16:14481075-14496988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022414
protein coding gene Chr16:15319886-15335801 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023011
protein coding gene Chr16:14483804-14499719 (+)
PWK/PhJ MGP_PWKPhJ_G0021587
protein coding gene Chr16:14163331-14179704 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021415
protein coding gene Chr16:14459948-14475845 (+)
WSB/EiJ MGP_WSBEiJ_G0021891
protein coding gene Chr16:14476483-14492437 (+)



Homology
more
  • Human Ortholog
    P2RX6, purinergic receptor P2X 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    P2RX6, purinergic receptor P2X 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P2RXL1, P2X6, P2XM
  • Links
    NCBI Gene ID: 9127
    neXtProt AC: NX_O15547
    UniProt: O15547

  • Chr Location
    22q11.21; chr22:21009699-21028013 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit a significant increase in thermal response latency during hot plate testing, and are resistant to metrazol-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18440 NCBI Gene Model | MGI Sequence Detail 10158 C57BL/6J ±  kb
    transcript NM_011028 RefSeq | MGI Sequence Detail 2362 C57BL/6  
    polypeptide O54803 UniProt | EBI | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 6
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:51784 Nawa G, et al., Cloning and characterization of the murine P2XM receptor gene. J Hum Genet. 1998;43(4):262-7
    • Latest
      J:249011 de Baaij JH, et al., P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PLoS One. 2016;11(6):e0156803

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory