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P2rx6
Gene Detail
 Symbol
Name
ID
P2rx6
purinergic receptor P2X, ligand-gated ion channel, 6
MGI:1337113
Synonyms P2rxl1, P2xm
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:17561885-17577800 bp, + strand
From VEGA annotation of GRCm38

  15916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3975  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx6

Human
homologs
Human Homolog P2RX6, purinergic receptor P2X, ligand-gated ion channel, 6
NCBI Gene ID 9127
neXtProt AC  NX_O15547
Human Synonyms  P2RXL1, P2X6, P2XM
Human Chr (Location)  22q11.21; chr22:21015153-21028013 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit a significant increase in thermal response latency during hot plate testing, and are resistant to metrazol-induced seizures.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cation transport, ion transmembrane transport, ...
Component cell junction, cytoplasm, ...
Function ATP binding, extracellular ATP-gated cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 25, 28
Assay TypeResults
RT-PCR 3
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035232 (Evidence)
Ensembl Gene ModelENSMUSG00000022758 (Evidence)
Entrez Gene18440 (Evidence)
UniGene8032
DFCITC1591462, TC1641263, TC1676435
DoTSDT.91572982, DT.99849355
NIA Mouse Gene IndexU016875
Consensus CDS ProjectCCDS28007.2, CCDS49778.1
International Mouse Knockout Project StatusP2rx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035232 VEGA Gene Model | MGI Sequence Detail 15916 C57BL/6J ±  kb
transcript OTTMUST00000089807 VEGA | MGI Sequence Detail 2345 Not Applicable 
polypeptide OTTMUSP00000049114 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(7) UniProt(5)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003049 P2X6 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012193 P2X purinoceptor 6
References (Earliest) J:51784 Nawa G, et al., Cloning and characterization of the murine P2XM receptor gene. J Hum Genet. 1998;43(4):262-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory