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Eftud2
Gene Detail
Symbol

Name
ID
Eftud2
elongation factor Tu GTP binding domain containing 2
MGI:1336880
Synonyms
116kDa, Snrp116, U5-116kD
Feature Type
protein coding gene
Genetic Map
Chromosome 11
66.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:102838473-102880985 bp, - strand
From VEGA annotation of GRCm38

  42513 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3133  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EFTUD2
Gene Tree: Eftud2

Human
homologs
EFTUD2, elongation factor Tu GTP binding domain containing 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9343
neXtProt AC: NX_Q15029

Human Synonyms: MFDGA, MFDM, SNRNP116, Snrp116, Snu114, U5-116KD

Human Chr (Location): 17q21.31; chr17:44850287-44899625 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EFTUD2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Genomic Mutations involving Eftud2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Eftud2 interacts with 146 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process mRNA processing, RNA splicing
Component Cajal body, catalytic step 2 spliceosome, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
cDNA source data(245)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eftud2 ; ZFIN eftud2    NEW 
Molecular
reagents
All nucleic(245) cDNA(245)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000003085 (Evidence)
Ensembl Gene Model ENSMUSG00000020929 (Evidence)
Entrez Gene 20624 (Evidence)
UniGene 873
DFCI TC1573234, TC1658771, TC1729016
DoTS DT.101283631, DT.102551660, DT.110514941, DT.493852, DT.94233395, DT.97404251
NIA Mouse Gene Index U033489
Consensus CDS Project CCDS48947.1, CCDS48948.1
International Mouse Phenotyping Consortium Status Eftud2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003085 VEGA Gene Model | MGI Sequence Detail 42513 C57BL/6J ±  kb
transcript OTTMUST00000006349 VEGA | MGI Sequence Detail 3324 Not Applicable 
polypeptide OTTMUSP00000002991 VEGA | MGI Sequence Detail 972 Not Applicable 

For the selected sequences
All sequences(126) RefSeq(6) UniProt(12)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009022 Elongation factor G, III-V domain
InterPro IPR000795 Elongation factor, GTP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
InterPro IPR005225 Small GTP-binding protein domain
InterPro IPR005517 Translation elongation factor EFG/EF2, domain IV
InterPro IPR000640 Translation elongation factor EFG, V domain
InterPro IPR004161 Translation elongation factor EFTu/EF1A, domain 2
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000006927 116 kDa U5 small nuclear ribonucleoprotein component
References
(Earliest) J:48574 Fabrizio P, et al., An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J. 1997 Jul 1;16(13):4092-106
(Latest) J:208278 De Arras L, et al., Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity. Genetics. 2013 Dec 20;
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory